Get Your Personalized Supplement StackSupplement Stack Quiz

Bifidobacterium Longum Longum

Also known as: Bifidobacterium longum subsp. longum, B. longum, B. longum longum, Bifidobacterium longum

Overview

Bifidobacterium longum is a gram-positive, rod-shaped bacterium classified as a probiotic, predominantly found in the human gastrointestinal tract and fermented foods such as yogurt and kimchi. As a key member of the gut microbiota, this strain is associated with a variety of health-promoting effects, including enhancing gut health, supporting the immune system, and managing gastrointestinal disorders. Extensive research has established its role in maintaining gut integrity through the production of short-chain fatty acids (SCFAs) and its anti-inflammatory properties. Systematic reviews and meta-analyses have highlighted B. longum's efficacy in reducing the risk of necrotizing enterocolitis (NEC) in infants and combating visceral fat accumulation in adults. Its favorable safety profile underscores its popularity in probiotic supplementation, making it essential for those looking to improve digestive health.

Benefits

Key benefits of B. longum include: 1) Reduction in NEC: A meta-analysis of 15 randomized controlled trials involving 4481 infants showed a significant risk reduction for NEC (Relative Risk [RR] = 0.539). 2) Decreased Visceral Fat: Research indicated that supplementation led to observable decreases in both visceral and total body fat in adults. 3) Improved IBS Symptoms: A systematic review demonstrated enhanced quality of life and symptom relief in 796 patients with irritable bowel syndrome (IBS) after prolonged usage of B. longum. Populations that benefit most include preterm infants (lowering NEC risk) and adults suffering from obesity or IBS. The supporting research is robust, derived from well-conducted clinical studies and systematic analyses.

How it works

B. longum primarily colonizes the gut and produces short-chain fatty acids (SCFAs), which strengthen gut barrier integrity and alleviate inflammation. These beneficial bacteria also modulate the immune system by influencing gene expression related to immune responses, impacting metabolic pathways positively. The interactions of B. longum extend throughout the gastrointestinal, immune, and metabolic systems, essential for maintaining gut health and overall homeostasis.

Side effects

Overall, B. longum is regarded as safe for use in both infants and adults. Clinical studies have not reported commonly adverse effects, with rare side effects occurring at less than 1% not being typically documented. Common (>5%) or uncommon (1-5%) adverse events were not observed in trials. While interactions with medications are minimal, caution is advised for individuals with compromised immune systems. Pregnant women and preterm infants should consult healthcare professionals before starting probiotics, as monitoring may be warranted for these populations due to the introduction of probiotics.

Dosage

The effective dosage of B. longum generally ranges from 10^9 to 10^{10} colony-forming units (CFUs) per day, which varies based on specific study protocols. For infants, initial recommendations suggest starting doses between 10^8 and 10^9 CFUs daily. In adults, maximum dosages reaching up to 10^{10} CFUs have been effective without significant adverse effects. It is recommended to take B. longum with meals to enhance intestinal survival and sustain colonization. Additionally, incorporating fermented foods into the diet can optimize absorption and benefits.

FAQs

Is *B. longum* safe for everyone?

*B. longum* is generally safe for most people, but it should be used cautiously in immunocompromised individuals. Medical oversight is advisable.

When should I take *B. longum*?

It is recommended to take *B. longum* with meals to improve survival rates and promote effective gut colonization.

What health improvements should I expect?

Users may experience benefits such as reduced NEC risk in infants, improved fat composition in adults, and alleviated IBS symptoms.

Are there any common side effects?

Clinical studies have shown no significant side effects associated with *B. longum*, making it a well-tolerated probiotic.

Research Sources

https://www.ncbi.nlm.nih.gov/pubmed/31877410 – This meta-analysis of 15 randomized controlled trials involving 4481 infants examined the effects of Bifidobacterium longum on reducing the risk of necrotizing enterocolitis (NEC). Findings indicated a significant reduction in NEC risk (RR = 0.539), supporting the efficacy of probiotic supplementation in preterm infants.
https://www.ncbi.nlm.nih.gov/pubmed/29588191 – A systematic review assessed the impact of B. longum on individuals with irritable bowel syndrome (IBS). The review highlighted significant improvements in quality of life and symptom relief among 796 patients following prolonged usage, suggesting the strain's efficacy in treating IBS.
https://www.ncbi.nlm.nih.gov/pubmed/27757820 – The study explored the effects of probiotic supplementation, including B. longum, on visceral fat accumulation in adults. Results demonstrated that B. longum supplementation contributed to significant reductions in both visceral and total body fat, indicating its beneficial role in weight management.