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Bifidobacterium Longum Mak34b12l

Also known as: *Bifidobacterium longum*, strain Mak34b12l, Bifidobacterium longum (strain-specific identifier Mak34b12l), *Bifidobacterium longum* Mak34b12l

Overview

*Bifidobacterium longum* is a species of probiotic bacteria naturally found in the human gut microbiome. The strain Mak34b12l is specifically identified for its usage in dietary supplements aimed at promoting gastrointestinal health. Research indicates that this species can play a crucial role in modulating gut microbiota, potentially alleviating symptoms associated with gastrointestinal disorders such as irritable bowel syndrome (IBS) and reducing the risk of necrotizing enterocolitis (NEC) in infants. Evidence for the efficacy of this specific strain is still developing, with a moderate amount of studies focused on its properties compared to well-studied strains within the *Bifidobacterium longum* category. This strain is generally safe for healthy individuals, and its supplementation is often recommended in capsule or powder forms, with optimal dosages varying based on individual health needs.

Benefits

Research illustrates that *Bifidobacterium longum* can effectively reduce IBS symptoms, including abdominal pain and bloating. Specific data on the Mak34b12l strain remains limited, but other strains within this species have demonstrated these benefits in clinical settings; for instance, significant symptom reduction was noted in various studies after an 8-week supplementation course. Additionally, this strain shows promise in decreasing the risk of NEC in infants, indicating its wider applicability, though clinical evidence remains to solidify these findings specifically for Mak34b12l. Pregnant and breastfeeding women, alongside individuals with IBS, appear to benefit the most from supplementation. Overall, while evidence is compelling for general *Bifidobacterium longum* strains, more research is needed to establish the effectiveness of the Mak34b12l strain explicitly.

How it works

*Bifidobacterium longum* exerts its effects primarily by modulating the gut microbiota, which can influence inflammatory responses and strengthen gut barrier function. It facilitates a balance in cytokine production, pertinent for immune response, such as modifications in IL-10 and IL-12 levels. This interaction with the gastrointestinal system aids in improving overall gut health and can reduce the frequency and severity of gastrointestinal symptoms.

Side effects

Generally considered safe, *Bifidobacterium longum* Mak34b12l might cause mild gastrointestinal symptoms, such as bloating or gas in some individuals (reported in over 5% of users). No serious side effects are commonly associated with its use, though rare, severe adverse events can occur. The risk of adverse effects may be heightened in immunocompromised individuals; thus, this group should consult healthcare providers before using the supplement. Additionally, drug interactions appear minimal. Caution may also be warranted for those undergoing treatment for severe immunodeficiency or critical illness, reinforcing the need for medical guidance in these populations.

Dosage

The recommended dosage for *Bifidobacterium longum* Mak34b12l generally falls between 10^6 to 10^10 CFU (colony-forming units) per day, with many studies indicating that doses of 10^8 to 10^10 CFU are particularly effective for alleviating IBS symptoms. It is advisable to take the supplement with food to enhance its survival through the acidic environment of the stomach, which aids in effective colonization. While there are no strictly defined maximum safe doses, using doses commonly at or below 10^10 CFU is recommended to ensure safety and efficacy.

FAQs

How should I store *Bifidobacterium longum* Mak34b12l?

It should be stored in a cool, dry place, preferably in the refrigerator to maintain its viability.

Is *Bifidobacterium longum* Mak34b12l safe for everyone?

While generally safe, individuals who are immunocompromised should consult a healthcare professional before use.

When is the best time to take this probiotic?

It is best taken with meals to improve its survival during digestion.

How long before I notice benefits from taking this probiotic?

Many users may start noticing benefits after several weeks of consistent use.

Can this supplement cure gastrointestinal issues?

It is not a cure-all; effectiveness can vary by individual and by specific gastrointestinal condition.

Research Sources

https://www.microbiotajournal.com/article/998 – This study discussed the role of *Bifidobacterium longum* in improving IBS symptoms, highlighting a significant effect observed over an 8-week period, despite limitations in sample size.
https://pubmed.ncbi.nlm.nih.gov/38137255/ – This RCT illustrated significant reductions in abdominal discomfort for IBS patients using *Bifidobacterium longum* 35624, noting the importance of strain-specific effects.
https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/06/e998.pdf – The meta-analysis outlined how *Bifidobacterium longum* can significantly reduce the risk of NEC in infants, which could support its use in pediatric populations.
https://pubmed.ncbi.nlm.nih.gov/33349590/ – A review of studies found promising results for self-reported improvements in IBS symptoms linked to *Bifidobacterium longum*, emphasizing the need for more well-designed trials.
https://www.mdpi.com/2304-8158/12/24/4451/review_report – This comprehensive review report assessed various strains of *Bifidobacterium longum* and their implications for gut health, supporting the exploration of specific strains like Mak34b12l.