Bio Active Blend For Women
Also known as: Soy isoflavones, Black cohosh, Chasteberry, Evening primrose oil, Glycine max, Cimicifuga racemosa, Vitex agnus-castus, Oenothera biennis, Bio Active Blend For Women
Overview
The Bio Active Blend For Women is a nutraceutical supplement designed to alleviate menopausal symptoms and support skin health in post-menopausal women. It combines extracts from *Glycine max* (soy isoflavones), *Cimicifuga racemosa* (black cohosh), *Vitex agnus-castus* (chasteberry), and *Oenothera biennis* (evening primrose oil). These ingredients are known for their phytoestrogenic and antioxidant properties. The blend is primarily used to reduce hot flushes, mood disturbances, and sleep problems associated with menopause, while also improving skin elasticity, roughness, and overall antioxidant status. Research, including randomized controlled trials, indicates moderate to high-quality evidence supporting its efficacy and safety over a 12-week period.
Benefits
This blend offers significant benefits for post-menopausal women aged 45–60 years. It leads to a substantial reduction in menopausal symptoms, including hot flushes, sweating (p < 0.0001), sleep problems (p < 0.0005), depressed mood (p = 0.0004), and irritability (p < 0.0003) after 12 weeks of supplementation compared to placebo. Furthermore, it significantly improves skin parameters, showing enhanced elasticity (Cohen’s d = 1.56), reduced roughness (d = 1.53), and improved smoothness (d = −1.33), scaliness (d = −0.80), and wrinkles (d = −1.02). The blend also boosts antioxidant status by increasing glutathione (GSH) and decreasing malondialdehyde (MDA), indicating reduced oxidative stress. Secondary benefits include a reduction in serum LDL cholesterol and triglycerides, and decreased C-reactive protein levels, suggesting potential cardiovascular and anti-inflammatory advantages. These benefits are supported by high-quality randomized controlled trials with large effect sizes, with improvements observed as early as 6 weeks for some skin parameters and sustained at 12 weeks for menopausal symptom relief.
How it works
The Bio Active Blend For Women primarily works through the synergistic action of its botanical components. Phytoestrogens from soy isoflavones and black cohosh are believed to modulate estrogen receptors, particularly estrogen receptor beta (ERβ), which helps to partially compensate for the decline in endogenous estrogen during menopause, thereby alleviating menopausal symptoms. The antioxidant properties, largely contributed by evening primrose oil and other extracts, reduce systemic and skin oxidative stress by enhancing antioxidant enzymes like glutathione and reducing lipid peroxidation markers such as malondialdehyde. This blend also exhibits anti-inflammatory effects, evidenced by reduced C-reactive protein levels, and positively influences lipid metabolism by decreasing LDL cholesterol and triglycerides. The ingredients are administered orally, and their bioavailability, especially for soy isoflavones, can be influenced by gut microbiota.
Side effects
The Bio Active Blend For Women has been reported as well-tolerated in clinical trials over a 12-week period, with no adverse effects reported in the cited randomized controlled trials. Specifically, there were no common (>5%), uncommon (1-5%), or rare (<1%) side effects observed. While no specific drug interactions were reported in these studies, caution is advised regarding potential interactions with hormone therapies or anticoagulants due to the phytoestrogen content. The blend is contraindicated in individuals with hormone-sensitive conditions, although this is not explicitly stated in the research, it is a general precaution for phytoestrogen-containing supplements. The safety profile is established for healthy post-menopausal women aged 45-60 years; safety in other populations or for longer durations has not been established.
Dosage
The optimal dosage for the Bio Active Blend For Women is based on proprietary formulations used in clinical studies. While exact individual ingredient dosages are not fully disclosed, they are consistent with typical nutraceutical formulations, generally containing standardized soy isoflavones (~40-80 mg/day), along with black cohosh, chasteberry, and evening primrose oil. The supplement should be taken daily via oral administration (capsules or tablets) for at least 12 weeks to achieve the reported benefits. There is no established maximum safe dose, as no adverse effects were reported at the study doses. Timing considerations suggest that bioavailability may be enhanced when taken with meals. No specific cofactors are required for its efficacy. Gut microbiota status may influence the metabolism and absorption of isoflavones.
FAQs
Is it safe for long-term use?
Current evidence supports safety for at least 12 weeks; however, longer-term safety data beyond this period are not yet available from the conducted studies.
How soon will benefits appear?
Some improvements in skin parameters can be observed as early as 6 weeks, while significant relief from menopausal symptoms typically becomes apparent by 12 weeks of consistent use.
Can it replace hormone replacement therapy (HRT)?
This blend may serve as a safer alternative or adjunct to HRT for some women, but it is not a direct replacement. Consult a healthcare provider for personalized advice.
Are there any side effects?
Clinical trials reported no adverse side effects during the 12-week study period, indicating it is generally well-tolerated.
Does it affect hormone levels?
Studies have shown no significant changes in serum estrogen or other hormone levels, suggesting it modulates symptoms without altering systemic hormone balance.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/33331798/ – This randomized, double-blind, placebo-controlled trial involving 101 post-menopausal women demonstrated that the Bio Active Blend significantly reduced menopausal symptoms (hot flushes, mood, sleep problems) and improved cardiovascular markers (decreased CRP, LDL-C, triglycerides) over 12 weeks, without altering hormone levels or causing adverse effects. It provides strong evidence for the blend's efficacy in symptom management.
- https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14345 – This RCT, involving 110 post-menopausal women, found that the Bio Active Blend significantly improved various skin parameters, including elasticity, roughness, smoothness, and wrinkles, and enhanced antioxidant status (increased glutathione, decreased MDA) over 12 weeks. The study highlights the blend's benefits for skin health and its antioxidant properties, with large effect sizes and no reported adverse effects.
- https://www.semanticscholar.org/paper/Effects-of-a-combination-of-botanical-actives-on-in-Tumsutti-Maiprasert/463ccc3ddf06e1846605d093fd699c73baece187 – This paper, likely a precursor or related work to the published RCTs, details the effects of the botanical actives on skin health and antioxidant status. It supports the findings of improved skin elasticity, reduced wrinkles, and enhanced antioxidant markers, reinforcing the blend's efficacy in combating age-related skin changes and oxidative stress in post-menopausal women.
Supplements Containing Bio Active Blend For Women
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