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Bioflavonoids Extract

Also known as: bioflavonoids, flavonoids, polyphenols, flavan-3-ols, anthocyanins, flavonols, isoflavones, Bioflavonoids

Overview

Bioflavonoids are a diverse class of plant compounds, primarily categorized under flavonoids, and are abundant in various foods such as fruits, vegetables, tea, and wine. These compounds are recognized for their antioxidant and anti-inflammatory properties, which contribute to their potential health benefits, including support for cardiovascular health and enhancement of ocular functions. The research on bioflavonoids is moderately mature, with a growing body of evidence demonstrating their effects on health conditions such as glaucoma and improving eye health. While there are some high-quality studies corroborating their benefits, the variable quality of research indicates a need for further investigation into the effectiveness of specific subclasses and their broader health implications.

Benefits

Bioflavonoids, particularly flavan-3-ols and anthocyanins, have demonstrated significant positive effects on eye health, specifically in conditions like glaucoma, with a notable standard mean difference of −0.39 (95% CI: −0.56, −0.21) in meta-analyses. Additional studies suggest potential cardiovascular benefits, but evidence for these claims is less robust. Older adults appear to gain the most from flavonoid supplementation concerning ocular health. Overall, substantial improvements in ocular health have been observed, though more research is necessary to validate benefits for athletic performance and cardiovascular outcomes.

How it works

Bioflavonoids exert their effects primarily through antioxidant mechanisms, neutralizing free radicals and reducing oxidative stress. They interact with several biological pathways, particularly those involved in inflammation and cardiovascular health. The compounds influence various enzymes and receptors that play roles in these processes, promoting improved vascular function and potentially reducing injury to retinal cells in the eyes. Though bioavailability is generally low, co-consumption with food can enhance absorption, allowing for greater efficacy.

Side effects

Bioflavonoids are generally considered safe, though some individuals may experience gastrointestinal discomfort, particularly at higher doses. Common adverse effects occur in more than 5% of users and may include digestive issues. Allergic reactions occur in 1-5% of cases, while severe side effects (<1%) are not well-documented in existing literature. Caution is advised in patients using blood thinners, as bioflavonoids may augment effects. Pregnant and breastfeeding women should also avoid supplementation due to insufficient safety data. Individuals with bleeding disorders should use bioflavonoids with particular caution due to potential anticoagulant effects.

Dosage

While a specific minimum effective dose has not been firmly established, a typical starting dose is around 100 mg per day, with a recommended dosage range of 100-500 mg daily, based on the specific subclasses of bioflavonoids. Doses exceeding 1,000 mg may lead to increased side effects. To enhance absorption, it is advisable to take bioflavonoid supplements with meals. Common forms for supplementation are capsules or tablets, and while no specific cofactors are required for efficacy, food intake can significantly improve their absorption rates.

FAQs

Are bioflavonoids safe to take?

Bioflavonoids are generally safe but consult a healthcare professional, especially if on medication.

Can bioflavonoids cause side effects?

Yes, high doses may lead to gastrointestinal issues; allergic reactions are also possible.

When is the best time to take bioflavonoids?

Bioflavonoids are best taken with meals to enhance their absorption.

What health issues can bioflavonoids help with?

Notably, they may improve eye health and potentially support heart health.

Are bioflavonoids a cure-all for health issues?

No, bioflavonoids provide condition-specific benefits and should not be viewed as a universal remedy.

Research Sources

  • https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.651441/full – This systematic review and meta-analysis evaluates the impact of flavonoids on ocular health, with positive outcomes particularly linked to flavan-3-ols and anthocyanins. It highlights significant benefits for glaucoma and other ocular disorders across 724 participants, noting variability in study designs.
  • https://www.mdpi.com/2072-6643/15/21/4547 – This analysis discusses the effects of flavonoids on athletic performance, particularly aerobic endurance, across 22 studies involving healthy adults. However, it notes significant heterogeneity in the designs and outcomes of the included studies, indicating moderate overall quality.
  • https://pubmed.ncbi.nlm.nih.gov/23953879/ – The publication examines the broader implications of flavonoid intake, discussing their influence on health and longevity, but it lacks comprehensive data about specific high-quality studies on various health aspects linked to bioflavonoids.
  • https://www.scirp.org/journal/paperinformation?paperid=105983 – This research paper presents findings in the context of antioxidant effects attributed to flavonoids, reinforcing the importance of these compounds in managing oxidative stress and inflammation.
  • https://onlinelibrary.wiley.com/doi/10.1002/ptr.8190 – This resource provides insights into the pharmacological evaluations of bioflavonoids, summarizing the potential therapeutic applications across various ailments while identifying gaps in research on specific health priorities.

Supplements Containing Bioflavonoids Extract

Vitamin C 1000 mg by Natural Factors
88

Vitamin C 1000 mg

Natural Factors

Score: 88/100
Quercetin by Natural Factors
70

Quercetin

Natural Factors

Score: 70/100
Quercetin by Natural Factors
70

Quercetin

Natural Factors

Score: 70/100
Athletic Greens Ultimate Daily by Athletic Greens
80

Athletic Greens Ultimate Daily

Athletic Greens

Score: 80/100
Vitamin C 1000 mg by Natural Factors
82

Vitamin C 1000 mg

Natural Factors

Score: 82/100
Citrus Bioflavonoids 650 mg by Natural Factors
80

Citrus Bioflavonoids 650 mg

Natural Factors

Score: 80/100
Morning Man Greens by Morning Man
58

Morning Man Greens

Morning Man

Score: 58/100
Liquid Eye Care Natural Orange And Strawberry Flavors by Nature's Answer
73

Liquid Eye Care Natural Orange And Strawberry Flavors

Nature's Answer

Score: 73/100

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