Blis M18 Probiotic Bacteria
Also known as: Blis M18 Probiotic Bacteria, S. salivarius M18, *Streptococcus salivarius* M18
Overview
*Streptococcus salivarius* M18 is a probiotic strain naturally found in the oral cavity and is utilized in various products aimed at enhancing oral health. It is primarily known for reducing the levels of *Streptococcus mutans*, a bacterium closely linked to dental caries. The strain produces bacteriocins, which are antimicrobial peptides that inhibit the growth of harmful bacteria, thus promoting a healthier microbial ecosystem in the mouth. While research indicates positive outcomes related to its use in enhancing oral microbiota, further robust clinical trials are needed to firmly establish its efficacy and optimal dosage. Applications include incorporation into toothpaste and lozenges.
Benefits
The primary benefit of *S. salivarius* M18 is its ability to significantly reduce *Streptococcus mutans* biofilm formation, potentially lowering the risk of dental caries. Studies show this effect is notable in vitro, suggesting that individuals at risk of dental caries may gain the most benefit from this probiotic. Secondary benefits include overall improvement in oral health by fostering a balanced oral microbiome. However, while positive findings exist, the evidence base is still developing, as more clinical trials are necessary to quantify the in vivo effectiveness and time course of these benefits.
How it works
*Streptococcus salivarius* M18 operates by producing bacteriocins that specifically target and inhibit the growth of pathogenic bacteria, including *Streptococcus mutans*, thus affecting their biofilm formation ability. The interaction is localized within the oral cavity, where these antimicrobial substances disrupt the integrity of bacterial cell membranes, which leads to decreased colonization and adverse effects on microbial balance. This localized action allows for modulation of the oral microbiome without systemic absorption.
Side effects
Overall, *S. salivarius* M18 is regarded as safe for oral use with no common or documented adverse effects in existing studies. No rare side effects or known drug interactions have been established. There are no contraindications noted, and it appears to pose no specific risks to special populations, including pregnant women or children. However, the lack of comprehensive data suggests caution, and further research is warranted to confirm these safety profiles.
Dosage
The effective dosage of *S. salivarius* M18 is not well-defined, as it is often included in products like toothpaste or lozenges that may vary in CFU per serving. Regular use is advised for sustained oral health benefits. Optimal dosing requires further exploration, and although there is no established maximum safe dosage, it is encouraged to follow product guidelines. Factors regarding absorption are not applicable since the strain operates locally in the mouth without systemic effects.
FAQs
How often should it be used?
Regular use is recommended for optimal benefits, particularly in oral care products.
Is it safe for everyone?
Generally safe for most, but more data is needed for specific populations like pregnant women or young children.
What timing considerations are there for its use?
Follow product label instructions, ensuring consistent daily use for best results.
What results can I expect?
Potential reduction in *S. mutans* levels and improved overall oral health with regular use.
Can it replace my dental hygiene routine?
No, it should complement regular dental hygiene practices, not replace them.
Research Sources
- https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2022.884683/full – This study demonstrates the in vitro efficacy of *S. salivarius* M18 in inhibiting *S. mutans* biofilm formation, providing high-quality data supporting its antimicrobial action but highlighting the need for in vivo validation.
- https://pubmed.ncbi.nlm.nih.gov/38064222/ – A probiotic toothpaste trial revealing positive participant feedback regarding sensory properties and effective colonization by *S. salivarius* M18, although limited by a small sample size and lack of controls.
- https://www.mdpi.com/2673-8007/5/1/14 – This systematic review emphasizes the necessity for improved methodological reporting in probiotic studies, although it does not focus specifically on *S. salivarius* M18.
- https://www.tandfonline.com/doi/full/10.1080/20002297.2024.2304971 – The paper presents an overview of recent findings related to oral probiotics, underscoring the importance and potential clinical benefits of utilizing strains like *S. salivarius* M18.
- https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1161155/full – Investigates the broader applications and effects of oral probiotics, including *S. salivarius* M18, while calling for more comprehensive clinical research to substantiate claims.
Supplements Containing Blis M18 Probiotic Bacteria
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