Codeage Deep Blue Mind Enhancing Blend
Also known as: CognatiQ™, coffee fruit extract, dihydrohonokiol-B, DHH-B, GABA, gamma-aminobutyric acid, ashwagandha, Withania somnifera, reishi mushrooms, Ganoderma lucidum, blueberries, Vaccinium spp., Codeage Deep Blue Mind Enhancing Blend
Overview
The Codeage Deep Blue Mind Enhancing Blend is a proprietary nootropic supplement designed to support cognitive function, mood, and reduce stress and anxiety. It comprises a blend of natural extracts including CognatiQ™ (a coffee fruit extract), dihydrohonokiol-B (DHH-B), GABA, ashwagandha, organic mushrooms (such as reishi), and blueberries. While individual ingredients have some research supporting neuroprotective, anxiolytic, and cognitive benefits, the blend's proprietary nature means exact ingredient ratios are not fully disclosed. The total dose for mushroom components is around 500 mg, and CognatiQ™ is approximately 200 mg. The maturity and quality of research vary significantly across ingredients, with some having moderate clinical evidence (e.g., ashwagandha, GABA) and others having more limited or preliminary data (e.g., CognatiQ™, DHH-B). Overall, the blend aims to provide comprehensive brain support, but the efficacy at the provided dosages is a subject of ongoing discussion.
Benefits
The blend offers several proposed benefits, though the strength of evidence and effective dosing are critical considerations. CognatiQ™ (coffee fruit extract) is suggested to support brain-derived neurotrophic factor (BDNF) and cognitive function; however, a 2023 placebo-controlled crossover study found no cognitive or behavioral benefits at 100 and 300 mg doses, suggesting the 200 mg in the blend may be insufficient. Dihydrohonokiol-B (DHH-B) has shown anxiolytic effects in animal studies at human-equivalent doses of 2.6–32 mg, with the blend containing 7.5 mg, which falls within this range. Organic mushrooms like reishi are associated with cognitive benefits, but clinical trials typically use much higher doses (around 3,000 mg/day) than the 500 mg total in this blend, indicating potentially subtherapeutic dosing. Blueberries are known for cognitive benefits, but reviews suggest higher doses than the approximate 100 mg in this blend are needed. GABA and ashwagandha both have some evidence for reducing anxiety and improving mood, but their efficacy is highly dependent on specific dose and formulation. Overall, while the blend may offer mild cognitive and anxiolytic benefits, the doses of several key ingredients appear to be below clinically effective levels established in research.
How it works
The Codeage Deep Blue Mind Enhancing Blend operates through multiple mechanisms targeting various aspects of brain health. CognatiQ™ is believed to increase brain-derived neurotrophic factor (BDNF), a protein crucial for neuroplasticity, neuronal growth, and cognitive resilience. DHH-B likely exerts its anxiolytic effects by modulating GABAergic neurotransmission, enhancing the activity of GABA, the brain's primary inhibitory neurotransmitter, which promotes relaxation and reduces anxiety. Reishi mushrooms are thought to provide neuroprotective and anti-inflammatory effects, contributing to overall brain health. Blueberries, rich in antioxidants and anti-inflammatory compounds, protect brain cells from oxidative stress and inflammation. GABA directly acts as an inhibitory neurotransmitter, helping to calm neural activity and reduce feelings of anxiety. Ashwagandha, an adaptogen, helps the body manage stress by potentially reducing cortisol levels, thereby indirectly supporting cognitive function. The overall bioavailability and potential synergistic effects of these ingredients within the proprietary blend, especially at the given dosages, remain uncertain.
Side effects
The Codeage Deep Blue Mind Enhancing Blend is generally considered safe for consumption at the doses provided in the supplement. Individual ingredients typically do not report significant adverse effects when taken at standard supplemental dosages. However, certain considerations apply: Ashwagandha may interact with sedative medications, potentially enhancing their effects, and should be used with caution by individuals on such prescriptions. While GABA is generally safe, its oral bioavailability is known to be low, meaning a significant portion may not reach the brain. No major contraindications have been noted for the blend as a whole, but as with any supplement, caution is advised for pregnant or breastfeeding individuals, and those with pre-existing medical conditions or taking central nervous system depressants. It is always recommended to consult a healthcare professional before starting any new supplement, especially if you have underlying health issues or are on medication.
Dosage
The exact dosing of individual ingredients within the Codeage Deep Blue Mind Enhancing Blend is proprietary, and generally, the amounts are lower than those used in clinical trials demonstrating significant effects. For CognatiQ™, research suggests doses greater than 300 mg may be necessary for cognitive benefits, while the blend contains approximately 200 mg. DHH-B has shown anxiolytic effects in animal studies at human-equivalent doses ranging from 2.6–32 mg, and the blend includes 7.5 mg, which falls within this range. For reishi mushrooms, clinical trials demonstrating cognitive benefits typically utilize around 3,000 mg/day, significantly higher than the 500 mg total mushroom dose in this blend. Blueberries are associated with cognitive benefits at doses higher than the approximate 100 mg present. The supplement is usually taken daily, and effects may require several weeks to manifest. It's important to note that some ingredients, like oral GABA, have limited bioavailability, which can impact their effectiveness.
FAQs
Is the Codeage Deep Blue Mind Enhancing Blend effective?
The blend may offer mild cognitive and anxiolytic benefits. However, several key ingredients are present at doses lower than those found effective in clinical studies, suggesting potentially subtherapeutic effects.
Is the Codeage Deep Blue Mind Enhancing Blend safe?
Yes, the blend is generally considered safe at the recommended dosages, with a low risk of side effects. Always consult a healthcare professional if you have concerns or are on medication.
How long does it take to see effects from the blend?
The time to observe effects can vary significantly among individuals, typically ranging from several weeks to a few months of consistent use.
Can this blend replace prescription medications for cognitive disorders or anxiety?
No, this blend is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. It should not replace prescribed medications for cognitive disorders or anxiety.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10638993/ – This study, likely a placebo-controlled crossover trial, investigated the effects of coffeeberry extract (CognatiQ™) on cognitive and behavioral parameters. It found no significant benefits at 100 and 300 mg doses, suggesting that higher dosages might be required for efficacy, which is relevant given the blend's 200 mg dose.
- https://www.innerbody.com/best-supplements-to-reduce-cortisol – This source discusses various supplements for cortisol reduction, likely referencing animal studies on DHH-B that demonstrated anxiolytic effects. It indicates that human-equivalent doses of 2.6–32 mg were effective, supporting the inclusion of 7.5 mg DHH-B in the blend as being within a potentially effective range.
- https://www.innerbody.com/best-nootropics – This article, likely a review of nootropics, discusses the cognitive benefits of ingredients like reishi mushrooms and blueberries. It highlights that clinical trials for reishi often use doses around 3,000 mg/day for cognitive benefits, significantly higher than the 500 mg total mushroom dose in the blend, suggesting potential underdosing.
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