ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Blueberry Wild

Also known as: Vaccinium angustifolium, Vaccinium corymbosum, Blueberries, Wild Blueberries

Overview

Blueberries, particularly the wild variety (*Vaccinium angustifolium*), are small, round fruits native to North America, renowned for their deep purple color and exceptional antioxidant content. They are a rich natural source of anthocyanins and other polyphenols, which are responsible for their vibrant hue and numerous potential health benefits. Consumed fresh, frozen, or as concentrated supplements, blueberries are primarily utilized for their potential to support cardiovascular health, enhance cognitive function, and provide robust antioxidant protection. Beyond their polyphenol content, blueberries are also a good source of fiber, essential vitamins, and minerals. Research into their health effects is ongoing, with a growing body of evidence from systematic reviews and meta-analyses supporting their efficacy, particularly in areas related to vascular health and cognitive performance.

Benefits

Blueberry supplementation has demonstrated several evidence-based benefits, primarily in cardiovascular and cognitive health. A systematic review and meta-analysis showed significant improvements in endothelial function, with a 1.50% increase in flow-mediated dilation (FMD) and a 0.26 increase in reactive hyperemia index (RHI), indicating better blood vessel health. This review also noted a decrease of 1.95 mmHg in diastolic blood pressure, with particularly notable improvements in both systolic and diastolic blood pressure among smokers. These improvements are considered clinically significant. Beyond cardiovascular effects, there is supporting evidence that blueberry polyphenols may enhance cognitive performance and potentially slow cognitive decline. Some studies also suggest positive effects on mood, though more research is needed to confirm this. Benefits can be observed within weeks of consistent supplementation, making blueberries a valuable dietary addition for overall health, especially for those looking to support vascular and brain health.

How it works

The health benefits of blueberries are primarily attributed to their rich content of polyphenols, especially anthocyanins. These compounds exert their effects through multiple biological pathways. Anthocyanins are potent antioxidants, helping to neutralize harmful free radicals and reduce oxidative stress throughout the body. They also play a crucial role in improving nitric oxide production, a key molecule for vasodilation and healthy blood flow, thereby enhancing endothelial function and potentially lowering blood pressure. By targeting pathways involved in inflammation and oxidative stress, blueberry polyphenols interact positively with the cardiovascular system, promoting better vascular health. The bioavailability of these polyphenols is generally good, allowing them to be absorbed and exert their beneficial effects within the body.

Side effects

Blueberries are generally considered safe when consumed in typical dietary amounts or as supplements. Common side effects are rarely reported, with no adverse effects occurring in more than 5% of users. Uncommon side effects, occurring in 1-5% of individuals, may include mild gastrointestinal upset. Rare side effects, affecting less than 1% of users, are primarily limited to allergic reactions, which are possible in individuals with a known allergy to blueberries. There are no significant drug interactions reported with blueberry consumption or supplementation; however, caution is advised for individuals taking medications that affect blood pressure or blood clotting, due to blueberries' potential effects on these parameters. There are no well-established contraindications, but individuals with a known allergy to blueberries should avoid them. Pregnant or breastfeeding women should consult a healthcare provider before taking blueberry supplements to ensure safety.

Dosage

While a minimum effective dose is not definitively established, studies have shown benefits with doses providing around 250 mg of anthocyanins. The optimal dosage range for blueberry supplements typically falls between 250-500 mg of anthocyanins per day. The maximum safe dose has not been formally established, and high doses are generally not recommended without medical supervision. There are no specific timing recommendations for blueberry supplementation; however, consistent daily intake is generally advised to achieve and maintain potential benefits. Common forms include freeze-dried powder or extracts. The absorption and bioavailability of blueberry polyphenols may be enhanced when consumed with food. No specific cofactors are identified as necessary to enhance their efficacy.

FAQs

Are blueberries safe for everyone?

Blueberries are generally safe and well-tolerated. However, individuals with known allergies to blueberries should avoid them. Pregnant or breastfeeding women should consult a healthcare provider before using supplements.

How long does it take to see benefits from blueberry supplementation?

Improvements in endothelial function and potential cognitive benefits may be observed within weeks of consistent daily supplementation, though long-term effects require continued use.

Can blueberries interact with medications?

No significant drug interactions have been reported. However, caution is advised if you are taking medications that affect blood pressure or blood clotting, due to blueberries' potential effects on these systems.

What is the best way to consume blueberries for health benefits?

Blueberries can be consumed fresh, frozen, or as supplements. Consistent daily intake, whether through diet or supplementation, is recommended to achieve potential health benefits.

Research Sources

  • https://pmc.ncbi.nlm.nih.gov/articles/PMC11180891/ – This systematic review and meta-analysis of 11 studies with 400 participants found that blueberry supplementation significantly improved endothelial function (FMD and RHI) and reduced diastolic blood pressure, especially in smokers. The study highlights the cardiovascular benefits of blueberries, though it notes variability in study designs.
  • https://www.mdpi.com/2072-6643/16/8/1180 – This research indicates that wild blueberry extract possesses potential cardiovascular benefits and may help attenuate cognitive decline in healthy older adults. While specific details on sample size and duration are limited, the study suggests a dual benefit for heart and brain health.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC10315404/ – This intervention study suggests that wild blueberry polyphenols are associated with improvements in both vascular function and cognitive performance. Although detailed methodology is not provided in the abstract, it supports the dual health benefits of blueberries on the circulatory system and brain.
  • https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-4-weeks-daily-wild-blueberry-supplementation-on-symptoms-of-depression-in-adolescents/E8ED12AC48E936A4A8D6664B93AD6AA6 – This study investigated the effect of 4 weeks of daily wild blueberry supplementation on symptoms of depression in adolescents. While the full findings are not detailed, it suggests an exploration into the potential mood-modulating effects of blueberries, indicating a broader scope of their health benefits beyond physical health.