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Boldo

Also known as: Boldo, Plectranthus barbatus, Coleus forskohlii, Coleus barbatus, Vernonia condensata, Peumus boldus

Overview

Boldo, primarily referring to *Peumus boldus*, is a South American plant traditionally used in folk medicine for its therapeutic properties, particularly for liver and gastrointestinal disorders. It contains alkaloids and flavonoids, with boldine being a key active compound. While traditionally used for liver and gastrointestinal ailments, scientific evidence supporting these uses is limited. Research is primarily based on traditional use and preclinical studies, with few human trials. Concerns exist regarding potential hepatotoxicity and adverse effects, highlighting the need for cautious use. Boldo is available in forms such as teas and infusions, reflecting its traditional preparation methods. Further research is needed to validate its efficacy and safety.

Benefits

Limited quantitative evidence supports the purported benefits of Boldo. Traditionally, it is believed to have protective effects on the liver due to its antioxidant properties, as suggested by some studies. Some research indicates potential antioxidant effects, which could be beneficial in conditions involving oxidative stress. However, the lack of robust clinical trials makes it difficult to establish effect sizes and clinical significance. No specific population benefits have been well-documented, and the time course of any potential benefits remains undefined. The available evidence is mostly qualitative, necessitating further rigorous investigation to confirm these benefits.

How it works

Boldo's mechanism of action is primarily attributed to its active compounds, such as boldine, which may exert antioxidant effects, potentially protecting against oxidative stress. These antioxidant properties could interact with the liver and gastrointestinal systems to provide protective effects. However, specific molecular targets are not well-documented, and there is limited information on the absorption and bioavailability of Boldo's active compounds in humans. Further research is needed to elucidate the precise biological pathways and interactions with body systems.

Side effects

Concerns exist regarding the safety profile of Boldo, particularly regarding hepatotoxicity, teratogenicity, and adverse pregnancy effects. Common side effects are not well-documented due to limited human studies. Potential liver damage and gastrointestinal issues are uncommon side effects. Specific rare side effects are also not well-documented. Potential interactions with other medications, especially those metabolized by the liver, are not well-studied. Pregnancy and liver conditions may be contraindications due to potential hepatotoxicity. Caution is advised in pregnant women and individuals with liver conditions. Users should be aware of these potential risks and exercise caution when using Boldo.

Dosage

A minimum effective dose for Boldo has not been established. Traditional use involves infusions or teas, but specific dosages are not standardized. The maximum safe dose is not well-defined due to safety concerns. No specific timing recommendations are available. Infusions or teas are traditional forms. There is limited information on absorption factors. Required cofactors are not established. Due to potential liver toxicity and a lack of robust safety data, users should be cautious. Further research is needed to determine safe and effective dosage guidelines.

FAQs

Is Boldo safe to use?

Boldo should be used with caution, especially in pregnancy or if you have liver conditions, due to potential liver toxicity and a lack of robust safety data.

How is Boldo traditionally consumed?

Traditional use involves regular consumption as a tea or infusion. However, it's important to be aware of potential risks.

What are the expected results from using Boldo?

Limited evidence supports specific health benefits. It is often believed to be safe without strong evidence supporting its safety, so caution is advised.

What should I be cautious about when using Boldo?

Users should be cautious due to potential liver toxicity and the lack of robust safety data. Consult with a healthcare professional before use.

Research Sources

  • https://rbpm.emnuvens.com.br/revista/article/view/128 – This systematic review assesses the safety of Boldo phytomedicines, highlighting reports of hepatotoxicity, teratogenicity, and adverse pregnancy effects from preclinical studies. The review emphasizes the need for further research due to the impaired methodological quality of the included studies, suggesting caution in the use of Boldo.
  • https://pubmed.ncbi.nlm.nih.gov/8202440/ – This review focuses on boldine's antioxidant properties and potential therapeutic uses. While it provides an overview of boldine's potential, it lacks clinical trial data, focusing more on chemical and pharmacological properties rather than clinical efficacy in humans.
  • https://www.mdpi.com/2076-3921/11/8/1419 – This article discusses the traditional uses, phytochemistry, and pharmacology of *Peumus boldus*. It highlights the presence of alkaloids and flavonoids, particularly boldine, and their potential therapeutic applications, while also noting the need for further research to validate these effects.
  • https://pubmed.ncbi.nlm.nih.gov/19145575/ – This experimental study on mice investigates the effect of Boldo infusion on lipoperoxidation induced by cisplatin. The findings suggest that Boldo infusion reduced lipoperoxidation, indicating potential antioxidant protective effects, although the study's applicability to humans is limited.
  • https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2821951 – This study is a systematic review and meta-analysis of herbal medicine use and liver injury. It highlights the potential for herbal medicines, including Boldo, to cause liver injury, emphasizing the need for caution and further research into the safety of herbal supplements.

Supplements Containing Boldo

Liver Wellness by Bio Nutrition
68

Liver Wellness

Bio Nutrition

Score: 68/100
Milk Thistle Liver Cleanse by Nature's Secret
60

Milk Thistle Liver Cleanse

Nature's Secret

Score: 60/100