Bovine Ovary Cytosol Extract
Also known as: Bovine ovary cytosol extract, Ovarian cytosol fraction (bovine), Bovine Ovary Cytosol Extract
Overview
Bovine Ovary Cytosol Extract is a complex biological extract derived from the soluble (cytosolic) fraction of bovine ovarian tissue. It contains a mixture of proteins, enzymes, and notably, steroid hormone receptors such as estrogen and progesterone receptors. While it is sometimes marketed or used in supplements aimed at supporting female reproductive health or hormonal balance, there are no standardized chemical identifiers or molecular characterization for it as a defined compound. Its primary characteristics stem from its origin, reflecting the hormonal environment of bovine ovarian tissue. Research on this extract is limited, primarily existing within veterinary and reproductive biology contexts, with no significant human clinical studies or approvals as a supplement ingredient. The quality of available evidence is sparse, lacking systematic reviews or meta-analyses on its use in humans.
Benefits
There are no high-quality randomized controlled trials (RCTs) or meta-analyses demonstrating clinical benefits of Bovine Ovary Cytosol Extract in humans. Research primarily focuses on the concentration of estrogen and progesterone receptors within bovine reproductive tissues, particularly in conditions like cystic ovarian disease. For instance, studies have observed elevated receptor concentrations in bovine uterus and ovary cytosol. However, this research is specific to bovine physiology and does not provide direct evidence of systemic or therapeutic effects in humans. Consequently, no specific benefits, population-specific advantages, or effect sizes have been established for human supplementation. The time course of any potential benefits also remains unestablished due to the complete lack of human clinical data.
How it works
Bovine Ovary Cytosol Extract contains estrogen receptors (ER) and progesterone receptors (PR), which are known to mediate hormone signaling in ovarian and uterine tissues in vivo. However, the mechanism by which these components might exert effects when ingested as an extract in humans is unknown. There is no data on the bioactivity or bioavailability of these receptors or other proteins from the extract when consumed orally. While it could theoretically interact with the endocrine and reproductive systems if active components were bioavailable, there is no evidence to confirm such interactions or systemic absorption in humans. The known molecular targets are the identified estrogen and progesterone receptors within the extract itself, but their functional relevance post-ingestion is unconfirmed.
Side effects
The overall safety of Bovine Ovary Cytosol Extract in humans is undocumented due to a complete lack of human studies. As a biological extract, potential risks could include immunogenicity (an immune reaction) or contamination, though specific instances are not reported. There are no documented common, uncommon, or rare side effects. Drug interactions are unknown, and contraindications have not been established; however, caution is advised in individuals with hormone-sensitive conditions dueing to the presence of steroid hormone receptors in the extract. No data exists for special populations, and pregnant or hormone-sensitive individuals should avoid this extract due to the unknown effects and potential risks.
Dosage
The minimum effective dose, optimal dosage ranges, and maximum safe dose for Bovine Ovary Cytosol Extract in humans are not established. There are no standardized formulations or dosing guidelines available. Timing considerations for administration are also unknown. Furthermore, information regarding absorption factors, bioavailability, or required cofactors for its potential activity is entirely lacking. Without any established clinical efficacy or safety data, specific dosage recommendations cannot be provided.
FAQs
Is bovine ovary cytosol extract effective for hormonal balance?
No, there is no clinical evidence from human studies to support the efficacy of bovine ovary cytosol extract for hormonal balance or any other health condition in humans.
Is it safe to consume?
The safety of bovine ovary cytosol extract in humans is unestablished. There is a complete lack of human safety data, and potential risks associated with biological extracts are unknown.
How quickly does it work?
There is no data available on the time course of effects for bovine ovary cytosol extract, as its efficacy and mechanism of action in humans are not established.
Can it affect estrogen or progesterone levels?
It is unknown if bovine ovary cytosol extract can affect human estrogen or progesterone levels. The presence of receptors in the extract does not imply hormonal activity when ingested.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/8342463/ – This study investigated estrogen and progesterone receptor concentrations in bovine ovarian and uterine tissues, finding elevated levels in cystic ovarian disease. It provides insights into bovine reproductive physiology but does not offer evidence for human supplementation.
- https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1028438/full – This in vitro study focused on the toxicological effects of BPA and its analogs on bovine granulosa cells, inducing apoptosis. It is an in vitro study on toxicology and has no direct relevance to the efficacy or safety of bovine ovary cytosol extract as a human supplement.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8112487/ – This source, likely related to the Vesanen et al. study, discusses receptor concentrations in bovine tissues. It reinforces the understanding of hormone receptors in bovine reproductive health but does not support the use of bovine ovary cytosol extract as a human supplement.
- https://www.nature.com/articles/s41392-022-01073-0 – This article discusses broader topics in reproductive biology or endocrinology, but its specific relevance to bovine ovary cytosol extract as a human supplement is not detailed in the provided context. It does not provide direct evidence for efficacy or safety.