Bovine Pituitary Pmg Extract
Also known as: Bovine Pituitary Extract, BPE, Pituitary Gland Extract
Overview
Bovine Pituitary Extract (BPE) is derived from the pituitary glands of young, healthy cattle, rich in growth factors and hormones that promote cellular proliferation. It’s primarily utilized in laboratory research, particularly in cell culture, where it serves to enhance cell growth and maintain the phenotype of cultured cells. BPE contains a diverse range of mitogens and differentiation factors, which facilitate these processes. While evidence supports its effectiveness in cell culture settings, there is a significant gap in data regarding the safety and efficacy of BPE for human consumption. Therefore, its primary application remains within research environments focused on cell biology and growth-related studies, rather than clinical use.
Benefits
The most notable benefit of BPE is its ability to enhance cell proliferation and maintain the phenotype of various primary cell types, especially keratocytes, in in vitro settings. Studies have shown that BPE regularly improves keratocyte proliferation rates when utilized at optimal concentrations (e.g., 40 µg/mL). Additionally, some evidence suggests that BPE may confer antioxidant protection in certain cell types. However, human studies are limited, and the benefits observed primarily pertain to its application in research rather than clinical or therapeutic settings.
How it works
Bovine Pituitary Extract functions by providing a mixture of growth factors and hormones that stimulate cell growth and differentiation. It likely interacts with cell surface receptors involved in signaling pathways for growth factors such as Growth Hormone (GH) and Fibroblast Growth Factor (FGF). The precise mechanisms remain poorly defined due to its use being primarily in laboratory conditions rather than in human subjects.
Side effects
Bovine Pituitary Extract is generally regarded as safe for use in research laboratories; however, there is a stark lack of safety data regarding human consumption, as it is primarily intended for cell culture applications. Common and rare side effects associated with human use are not documented, as the substance is not advised for human intake. Consequently, drug interactions and contraindications are not applicable. Caution is recommended when handling BPE in laboratory settings to prevent any unintended exposure.
Dosage
BPE is utilized in cell culture at concentrations typically ranging from 35 to 70 µg/mL, with 40 µg/mL noted as an optimal dosage for promoting keratocyte growth. Unlike dietary supplements intended for human consumption, BPE does not have established upper limits or safety thresholds for human use since its application is limited to research environments. It is continuously added to cell culture media to sustain biological activity, especially where growth factors are needed.
FAQs
Is Bovine Pituitary Extract safe for human consumption?
No, BPE is not intended for human consumption and has limited safety data for such use.
What are the primary applications of BPE?
BPE is primarily used in laboratory settings to enhance cell proliferation and maintain cell phenotypes in culture.
How is BPE administered in studies?
In cell culture studies, BPE is typically added continuously in media at specific concentrations.
Can BPE provide health benefits in humans?
There is no evidence supporting health benefits of BPE in humans, as it is used exclusively for research.
What is a common misconception about BPE?
A common misconception is that BPE is a dietary supplement for human use, which it is not.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3874512/ – This study explored the effects of Bovine Pituitary Extract on keratocyte proliferation, demonstrating significant enhancements in proliferation and better maintenance of keratocyte phenotype compared to traditional supplements.
- http://wvj.science-line.com/attachments/article/60/Booklet,%20Vol%2010,%20No%201,%20March%202020,%20WVJ.pdf – This publication discusses the role of BPE in various cell culture applications, highlighting its mitogenic properties essential for the growth of different cell types.
- https://www.mpbio.com/au/bovine-pituitary-extract-0928504-cf – This resource outlines the characteristics of BPE and its intended applications in research, particularly within cell culture settings.
- https://pubmed.ncbi.nlm.nih.gov/2383531/ – Research demonstrating the antioxidant activity of BPE in human prostate epithelial cells, revealing its protective effects against oxidative damage.
- https://pubmed.ncbi.nlm.nih.gov/14690452/ – A review discussing the utility of BPE in various cell culture methods, including insights on effective concentrations and applications in growing different cell types.
Supplements Containing Bovine Pituitary Pmg Extract
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