Brassaiopsis Glomerulata Extract
Also known as: Brassaiopsis glomerulata (Blume) Regel, Brassaiopsis herb, Brassaiopsis glomerulata
Overview
Brassaiopsis glomerulata is a plant native to Southeast Asia, particularly Indonesia, belonging to the Araliaceae family. Its leaves are the primary source of bioactive extracts investigated for potential hormonal modulation, specifically aromatase inhibition. It contains steroid, triterpenoid, modified peptide, fatty acid, monoterpenoid, and benzenoid compounds. Research is in early stages, primarily in vitro and animal studies, with limited human research. The quality of available evidence is moderate in vitro but low for human clinical trials. It is being explored for anti-inflammatory, analgesic, and muscle growth support, but these applications lack robust clinical validation. Due to the limited human data, caution is advised regarding its use as a supplement.
Benefits
The primary investigated benefit of Brassaiopsis glomerulata extract is aromatase inhibition, demonstrated in enzyme- and cell-based assays. Specific compounds like 6β-hydroxystimasta-4-en-3-one, linoleic acid, and *N*-benzoyl-L-phenylalanine methyl ester exhibit moderate activity. Indirect evidence suggests a potential for testosterone modulation by reducing estrogen conversion, but this has not been confirmed in human RCTs. Secondary effects, such as anti-inflammatory and analgesic properties, are supported by anecdotal and preliminary evidence but lack robust clinical data. The theoretical benefit of muscle growth support is based on aromatase inhibition and anabolic signaling but is not clinically validated. Clinical significance in humans remains unknown, and the time course of any potential benefits has not been studied.
How it works
Brassaiopsis glomerulata primarily works by inhibiting aromatase (CYP19A1), the enzyme responsible for converting androgens into estrogens. This inhibition may modulate sex hormone balance, potentially leading to increased testosterone levels relative to estrogen. Specific compounds within the extract, such as 6β-hydroxystimasta-4-en-3-one, linoleic acid, and *N*-benzoyl-L-phenylalanine methyl ester, have been identified as active aromatase inhibitors. However, the absorption and bioavailability of these compounds in humans have not been studied, limiting our understanding of its overall effectiveness.
Side effects
Due to limited human data, the overall safety profile of Brassaiopsis glomerulata is not well-established. Common, uncommon, and rare side effects have not been reported in human studies. There is a theoretical risk of drug interactions with hormone therapies or other aromatase inhibitors, but no clinical data confirms this. Contraindications are not established, but caution is advised in pregnancy, lactation, and individuals with hormone-sensitive conditions. Special population considerations, such as use in children, the elderly, or those with chronic diseases, have not been studied. Given the lack of comprehensive safety data, caution is warranted, and use should be under medical supervision.
Dosage
Effective, optimal, and maximum safe dosages of Brassaiopsis glomerulata have not been established in humans. Research has primarily used hexane and ethyl acetate extracts, but commercial forms may vary. Timing considerations and absorption factors are unknown. Due to the lack of human studies, no specific dosage recommendations can be made. It is crucial to consult with a healthcare professional before using this supplement, especially given the absence of established safety and efficacy data.
FAQs
Is Brassaiopsis glomerulata safe?
Human safety data are lacking. Use should be approached with caution and under medical supervision due to the absence of comprehensive clinical trials.
When and how should I take it?
Timing and administration have not been studied. No specific recommendations are available due to the limited research in humans.
What results can I expect?
Theoretical hormonal modulation is possible, but there are no proven benefits in humans. Claims of muscle growth or testosterone boosting are not supported by robust clinical evidence.
What are the common misconceptions about this supplement?
A common misconception is that it's a proven muscle growth or testosterone-boosting supplement. These claims lack substantial clinical evidence and should be viewed with skepticism.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2748821/ – This in vitro and cell-based assay investigated the aromatase-inhibiting effects of Brassaiopsis glomerulata extracts. The study found that hexane and ethyl acetate extracts inhibited aromatase, with specific compounds like 6β-hydroxystimasta-4-en-3-one showing moderate activity. The study is limited by the lack of human data and its restriction to enzyme and cell models.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8538516/ – This review article summarizes evidence for natural product extracts, including Brassaiopsis glomerulata, as aromatase inhibitors. It notes the strong in vitro activity and favorable safety profile observed in limited studies. The review is limited by its reliance on in vitro and animal studies, with no original human data presented.
- https://www.jstor.org/stable/25065918 – This resource provides taxonomic and botanical information about Brassaiopsis glomerulata. It confirms its classification within the Araliaceae family and its native distribution in Southeast Asia. The information is foundational for understanding the plant's origins and botanical characteristics.
- https://www.nutrahacker.com/journal_club/en/brassaiopsis-glomerulata.php – This overview highlights the potential for hormonal modulation, anti-inflammatory, and analgesic effects of Brassaiopsis glomerulata. It also notes the lack of clinical trials to support these claims. The resource is useful for context but should not be used for clinical conclusions due to its reliance on preliminary and anecdotal evidence.
- https://supplementsinreview.com/testosterone/brassaiopsis-glomerulata-testosterone/ – This website provides an overview of Brassaiopsis glomerulata and its purported effects on testosterone levels. It emphasizes that while some studies suggest potential benefits, more research is needed to confirm these effects in humans. The information presented should be interpreted cautiously due to the limited clinical evidence.
