Get Your Personalized Supplement StackSupplement Stack Quiz

Brazilian Brown Propolis Flavonoids

Also known as: brown propolis flavonoids, flavonoids from Brazilian brown propolis, Brazilian Brown Propolis Flavonoids

Overview

Brazilian brown propolis flavonoids are a complex mixture of polyphenolic compounds, including flavonoids and phenolic acids (e.g., caffeic acid, p-coumaric acid), derived from the resinous substance collected by bees from specific native plants in Brazil. This natural botanical supplement is primarily used for its antimicrobial, antioxidant, and anti-inflammatory properties. It is also studied for its potential benefits in oral health, particularly periodontal disease, and metabolic health. Research indicates its effectiveness against various bacteria and fungi, and it shows low mutagenic risk at typical concentrations. While several in vitro studies and some clinical trials exist, high-quality randomized controlled trials specifically on Brazilian brown propolis flavonoids are still limited, with much of the evidence coming from broader propolis research.

Benefits

Brazilian brown propolis flavonoids offer several evidence-based benefits. They exhibit significant antimicrobial activity, effectively inhibiting various pathogens including oral bacteria and Candida species in vitro. For periodontal health, a meta-analysis of randomized controlled trials (RCTs) showed that propolis supplementation significantly reduced bleeding on probing in periodontitis patients, with a modest but statistically significant mean difference of -0.39 (95% CI: -0.73 to -0.05). In terms of metabolic health, a systematic review and meta-analysis on propolis supplementation found a significant reduction in aspartate aminotransferase (AST) levels, suggesting potential liver protective effects, though no significant impact on lipid profiles or alanine aminotransferase (ALT) was observed. Secondary benefits include anti-inflammatory and antioxidant effects, which are supported by its rich flavonoid and phenolic acid composition and contribute to its overall therapeutic potential. These benefits have been observed in adults with periodontitis and metabolic disturbances, with safety confirmed at low concentrations in animal models.

How it works

The antimicrobial effects of Brazilian brown propolis flavonoids are primarily attributed to their ability to disrupt microbial cell walls and inhibit biofilm formation. As potent antioxidants, the flavonoids and phenolic acids within propolis scavenge reactive oxygen species, thereby reducing oxidative stress. It interacts with various body systems by modulating oral microbiota, reducing local inflammation in periodontal tissues, and potentially influencing systemic liver enzyme activity. At a molecular level, it targets microbial enzymes and membranes, as well as oxidative stress pathways in host cells. Some compounds, like acetylisocupressic acid, may also interact with cytochrome P450 enzymes. While specific pharmacokinetic data for these flavonoids are scarce, their oral bioavailability is generally considered moderate.

Side effects

Brazilian brown propolis flavonoids are generally considered safe at low concentrations, with preclinical studies showing no genotoxicity or mutagenicity at typical doses. However, as with all propolis products, allergic reactions are the most common concern. Individuals sensitive to bee products or propolis may experience mild allergic reactions, including skin rashes (allergic dermatitis) or, less commonly, mild gastrointestinal discomfort. Rare but severe allergic reactions, such as anaphylaxis, have been reported with propolis in general, though not specifically linked to Brazilian brown propolis flavonoids. Caution is advised regarding potential drug interactions, particularly with medications metabolized by cytochrome P450 (CYP450) enzymes, as some components like acetylisocupressic acid may interact with these pathways. Contraindications include a known allergy to bee products or propolis. Due to limited safety data, pregnant or breastfeeding women should exercise caution and consult a healthcare professional before use.

Dosage

Specific optimal dosage ranges for Brazilian brown propolis flavonoids are not yet well-established. In vitro studies have tested ethanolic extracts safely at concentrations of 0.5–7.5 mg/ml. Clinical studies on propolis supplements, which may contain varying amounts of these specific flavonoids, typically use total propolis extract doses ranging from 250 mg to 1000 mg per day. The maximum safe dose has not been clearly defined, but safety has been demonstrated at low to moderate doses in both animal and human studies. There are no specific timing recommendations; it is often taken orally with meals. For consistent flavonoid content, ethanolic extracts and standardized supplements are preferred. Co-administration with food may enhance absorption, and some flavonoids may require metabolic activation for full efficacy. No specific cofactors are identified as required for its action.

FAQs

Is Brazilian brown propolis flavonoids safe?

Yes, it is generally safe at typical doses, with preclinical models showing no mutagenic or genotoxic effects. Allergic reactions are possible in sensitive individuals.

Can it be used for periodontal disease?

Evidence suggests it can modestly improve markers of periodontal inflammation, such as reducing bleeding on probing.

Does it improve metabolic health?

Some research indicates it may improve liver enzyme levels (e.g., AST), but it has not shown clear benefits for lipid profiles.

How quickly do effects appear?

Clinical improvements have been reported within weeks to months, depending on the specific condition being addressed.

Are there allergy risks?

Yes, allergic reactions to propolis are possible, especially for individuals with sensitivities to bee products. Consult a doctor if you have concerns.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC9955532/ – This source discusses the chemical composition of Brazilian brown propolis, highlighting its unique profile of flavonoids, phenolic acids, and diterpenes like acetylisocupressic acid. It also presents findings from in vivo mutagenicity tests in Drosophila, indicating no mutagenic or genotoxic effects at low concentrations, supporting its safety profile.
https://www.scielo.br/j/bor/a/gFmyJVqtWnXKK3QzYHzRy8r/ – This meta-analysis evaluates the effect of propolis on periodontitis. It found that propolis supplementation significantly reduced bleeding on probing in patients, suggesting a modest but statistically significant clinical improvement in periodontal health, despite high heterogeneity among included studies.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8588957/ – This systematic review and meta-analysis investigates the impact of propolis supplementation on metabolic parameters. It reported a significant reduction in aspartate aminotransferase (AST) levels, indicating potential liver protective effects, but found no significant impact on lipid profiles or alanine aminotransferase (ALT).
https://www.scielo.br/j/aabc/a/6ry7bgfQnVPKQPcZ8VBX6Bt/ – This source provides insights into the antimicrobial properties of Brazilian brown propolis flavonoids. It highlights their significant antibacterial and antifungal activity in vitro, demonstrating their ability to inhibit various pathogens, including oral bacteria and Candida species, and their potential to disrupt microbial cell walls and biofilm formation.