Calcium Fructopyranose Borate
Also known as: Calcium fructoborate, CFB, Calcium fructopyranose borate
Overview
Calcium fructoborate (CFB) is a form of organic boron found in some plant-based foods and used as a dietary supplement. It is known for its potential anti-inflammatory properties and is often used to support joint health and cardiovascular function. CFB acts as a superoxide ion scavenger and may influence the production of inflammatory mediators. Research on CFB is still emerging, with several clinical studies suggesting benefits, but more systematic reviews and meta-analyses are needed to fully understand its effects. The available evidence is of moderate quality, with some well-designed randomized controlled trials (RCTs) showing promising results. CFB is generally considered safe, with negligible adverse effects reported in human studies.
Benefits
Calcium fructoborate (CFB) has demonstrated potential benefits, particularly in reducing joint discomfort. Studies have shown significant reductions in knee discomfort, as measured by WOMAC scores, within 14 days of supplementation. For example, one study reported a 13.73-point reduction in WOMAC scores compared to placebo. CFB is also recognized as a potential anti-inflammatory agent, although quantified outcomes in humans are somewhat limited. Secondary benefits may include support for cardiovascular health and oxidative metabolism. These benefits have primarily been studied in adults experiencing joint discomfort. While improvements in joint discomfort have been observed, further research is needed to fully understand the clinical significance of CFB across various conditions.
How it works
Calcium fructoborate (CFB) primarily functions as a superoxide ion scavenger, reducing oxidative stress and inflammation. It influences the production of inflammatory mediators, potentially affecting macrophage activity. CFB interacts with the immune and cardiovascular systems by reducing inflammation. At the molecular level, it inhibits the release of interleukin-1β and interleukin-6, key pro-inflammatory cytokines. While specific data on absorption and bioavailability are limited, its anti-inflammatory action contributes to its potential benefits for joint health and cardiovascular function.
Side effects
Calcium fructoborate (CFB) is generally considered safe, with negligible adverse effects reported in human studies. Common side effects (occurring in more than 5% of users) have not been reported. Uncommon (1-5%) and rare (less than 1%) side effects are not well-documented. No significant drug interactions have been reported, and there are no specifically identified contraindications. However, limited data are available on the use of CFB in pregnant women, children, or individuals with severe kidney or liver disease. As with any supplement, it is advisable to consult with a healthcare provider before use, especially for those with pre-existing health conditions or who are taking other medications.
Dosage
The minimum effective dose of calcium fructoborate (CFB) is typically studied at doses ranging from 108 to 220 mg per day. Optimal dosage ranges include 108 mg twice daily or 216 mg once daily, which have demonstrated efficacy in clinical studies. The maximum safe dose is not well-defined, but doses within the studied range are generally considered safe. There are no specific timing recommendations for CFB supplementation. No specific form recommendations exist, and limited data are available on absorption factors. No required cofactors have been identified. It is important to adhere to recommended dosage guidelines and consult with a healthcare provider for personalized advice.
FAQs
Is calcium fructoborate safe?
CFB is generally considered safe, with negligible adverse effects reported in studies. However, consult a healthcare provider before use, especially if you have pre-existing health conditions.
When should I take calcium fructoborate?
There are no specific timing recommendations for CFB supplementation. It can be taken at any time of day, with or without food, based on personal preference.
How long does it take to see results from calcium fructoborate?
Some studies suggest improvements in joint discomfort may be observed within 7-14 days of supplementation. Individual results may vary.
Is calcium fructoborate a cure for joint problems?
CFB is not a cure for severe joint conditions. It may help manage discomfort, but consult a healthcare provider for chronic issues and comprehensive treatment plans.
Are there any known interactions with medications?
No significant drug interactions have been reported, but it's always best to inform your healthcare provider about all supplements you are taking.
Research Sources
- https://www.dovepress.com/short-term-efficacy-of-calcium-fructoborate-on-subjects-with-knee-disc-peer-reviewed-fulltext-article-CIA – This RCT with 60 participants experiencing knee discomfort found that CFB supplementation significantly reduced knee discomfort over 14 days. The study used WOMAC scores to measure the reduction in discomfort. The short duration and limited sample size are limitations to consider.
- https://pubmed.ncbi.nlm.nih.gov/22435474/ – This study investigates the anti-inflammatory effects of calcium fructoborate. The research suggests that CFB can modulate inflammatory responses, potentially benefiting conditions associated with inflammation. Further clinical trials are needed to confirm these findings in human populations.
- https://www.jarlife.net/4535-effects-of-once-daily-versus-twice-daily-dosing-of-calcium-fructoborate-on-knee-discomfort-a-90-day-double-blind-placebo-controlled-randomized-clinical-study.html – This 90-day RCT involving 120 participants with knee discomfort compared once-daily and twice-daily dosing of CFB. Both dosing regimens significantly improved knee comfort over the study period. However, there were no significant differences observed between the two dosing schedules.
- https://pubmed.ncbi.nlm.nih.gov/21274653/ – This study explores the potential of CFB as an anti-inflammatory agent. The findings suggest that CFB can modulate inflammatory pathways, which may have implications for various health conditions. More research is needed to fully elucidate the mechanisms and clinical applications of CFB.
- https://www.researchgate.net/publication/256189177_Calcium_Fructoborate_Helps_Control_Inflammation_Associated_with_Diminished_Bone_Health – This publication discusses the role of calcium fructoborate in controlling inflammation associated with diminished bone health. It highlights CFB's potential to modulate inflammatory responses and support bone health. The review suggests that CFB could be a beneficial supplement for individuals with inflammatory conditions affecting bone health.