Calcium Potassium Phosphate Citrate
Also known as: Calcium citrate, Potassium citrate, Calcium phosphate, Calcium Potassium Citrate, Calcium Potassium Phosphate, Citrate salts, Calcium Potassium Phosphate Citrate
Overview
Calcium Potassium Phosphate Citrate is a compound reflecting the combination of calcium, potassium, phosphate, and citrate ions. These minerals are naturally found in various foods, such as dairy products (calcium and phosphate), fruits (citrate), and certain vegetables (potassium). This combination is primarily utilized for enhancing bone health, preventing kidney stones, and as a dietary supplement. Each component has distinct properties: calcium is essential for bone health, potassium contributes to cardiovascular wellness, phosphate is critical for bone and DNA structure, and citrate is known for its role in reducing kidney stone formation. While extensive research exists for the individual components, the specific combined formulation lacks direct clinical studies, meaning its effects are largely inferred from its parts rather than evaluated as a whole.
Benefits
The primary effects derived from the individual components include: Calcium Citrate has been shown to reduce urinary oxalate excretion, which may lower the risk of kidney stones. Potassium Citrate significantly increases urinary citrate levels, providing a protective effect against calcium oxalate stone formation, with a relative risk reduction of 74% observed in clinical settings. Additionally, these minerals support bone health, making this combination beneficial particularly for individuals at risk of osteoporosis or recurrent kidney stones. The benefits manifest over a long-term use period, with expected outcomes becoming noticeable several months after consistent supplementation. Evidence from various studies supports these claims, although the strength varies based on the specific substance.
How it works
Calcium and phosphate are vital for bone mineralization, promoting structural integrity in bone tissue. Potassium citrate increases urinary pH and citrate levels, which helps inhibit the crystallization of calcium salts, thus reducing the formation of kidney stones. These components interact principally with the urinary and skeletal systems, contributing to improved bone density and reduced stone formation. While specific mechanisms for the compound as a whole are not well studied, the known effects of its constituents provide insight into its potential benefits.
Side effects
Calcium Potassium Phosphate Citrate is generally regarded as safe when used appropriately, but potential side effects may arise. Common gastrointestinal disturbances, such as bloating, diarrhea, and stomach cramps, are reported in more than 5% of users. Less frequent side effects include mild allergic reactions and digestive issues, occurring in 1-5% of cases. There is limited documentation of rare side effects for the combined compound. Drug interactions may occur, particularly with medications such as tetracycline antibiotics and bisphosphonates, which may bind to the minerals in this supplement, reducing their effectiveness. Contraindications apply to those with hypercalcemia or severe kidney impairment, as excess intake could exacerbate their conditions. Special caution is advised for pregnant women and individuals suffering from kidney disease, who should consult healthcare providers before usage.
Dosage
For the specific compound Calcium Potassium Phosphate Citrate, no established dosage guidelines exist. However, based on individual components, calcium citrate is typically taken in daily doses of 500-1000 mg, while potassium citrate is usually recommended at doses around 40 mEq per day. It's advisable to take these supplements with meals to enhance absorption and minimize gastrointestinal side effects. Long-term usage may be required for optimal benefits. Although an exact maximum safe dose isn't established, intake should adhere to recommended dietary allowances for calcium and potassium. Dietary factors and individual health status can influence absorption, and Vitamin D may improve calcium assimilation.
FAQs
When should I take Calcium Potassium Phosphate Citrate?
It is recommended to take it with meals to enhance absorption and reduce gastrointestinal discomfort.
How long will it take to see results?
Benefits for bone health and stone prevention may take several months of consistent use to become noticeable.
Can it cure existing kidney stones?
No, it’s not a treatment for existing kidney stones but may reduce the formation of new ones.
Research Sources
- https://academic.oup.com/jbmr/article/37/7/1251/7516665 – A randomized, double-blind, crossover clinical trial demonstrated that calcium citrate significantly reduces urinary oxalate excretion in adults with chronic hypoparathyroidism.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4657843/ – A systematic review of 477 participants revealed that citrate therapy notably reduced new stone formation, with a relative risk reduction of 74%, although the quality of included studies varied.
- https://pubmed.ncbi.nlm.nih.gov/26439475/ – Animal studies suggested that potassium citrate elevates urinary citrate and pH levels but does not prevent calcium phosphate stone formation, hinting at the complexity of stone composition.
Supplements Containing Calcium Potassium Phosphate Citrate
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