Get Your Personalized Supplement StackSupplement Stack Quiz

Calm Proprietary Blend

Also known as: Calm Proprietary Blend, Calm Biotect, Inner Calm

Overview

Calm Proprietary Blend is a multi-ingredient dietary supplement designed to promote stress reduction, mood support, cognitive enhancement, and improved sleep quality. It typically includes a combination of herbal extracts and amino acids known for their calming and anxiolytic properties. Key ingredients often include organic valerian root extract, organic chamomile flower extract, organic passionflower extract, organic ashwagandha root and leaf extract, L-theanine, GABA, phosphatidylserine, and L-tryptophan. These components are selected for their synergistic effects on neurotransmitter modulation and stress response. While individual ingredients have been extensively studied, research on the specific proprietary blend is limited, relying primarily on studies of its individual components or similar combinations. The quality of evidence varies, with systematic reviews and meta-analyses available for some ingredients like valerian, ashwagandha, and L-theanine.

Benefits

The Calm Proprietary Blend offers several potential benefits, primarily related to stress reduction, sleep improvement, mood support, and cognitive focus. Ashwagandha has demonstrated cortisol-lowering effects and improved stress resilience in randomized controlled trials (RCTs). Valerian and chamomile extracts have shown efficacy in reducing sleep latency and improving subjective sleep quality in meta-analyses. L-tryptophan supports serotonin synthesis, potentially improving mood. L-theanine and phosphatidylserine have been linked to improved attention and memory in controlled studies. These benefits are most pronounced in adults experiencing mild to moderate stress, sleep disturbances, or cognitive fatigue. The combined effects of the blend are expected to be additive, though direct quantification is limited.

How it works

The Calm Proprietary Blend works through multiple biological pathways. Valerian, passionflower, and chamomile modulate GABA-A receptors, enhancing inhibitory neurotransmission. Ashwagandha acts as an adaptogen, modulating the hypothalamic-pituitary-adrenal (HPA) axis and reducing cortisol levels. L-theanine increases alpha brain wave activity, promoting relaxation without sedation. GABA directly acts as an inhibitory neurotransmitter, though its oral bioavailability is debated. L-tryptophan is a precursor to serotonin, influencing mood and sleep regulation. Phosphatidylserine supports neuronal membrane integrity and cognitive function. The absorption and bioavailability of these ingredients vary, with herbal extracts often standardized for active compounds to improve consistency.

Side effects

The Calm Proprietary Blend is generally considered safe when used at recommended doses. Common side effects, occurring in more than 5% of users, include mild gastrointestinal discomfort, headache, or drowsiness. Uncommon side effects (1-5%) may include allergic reactions and mild sedation. Rare side effects, affecting less than 1% of users, include thyroid hormone alterations reported with high-dose ashwagandha. Potential drug interactions exist with sedatives, thyroid medications, and antidepressants. It is contraindicated in pregnancy, breastfeeding, and individuals with thyroid disorders (caution with ashwagandha) or those using CNS depressants. Caution is advised in children, pregnant women, and those with autoimmune or thyroid conditions due to limited data.

Dosage

Typical doses in the Calm Proprietary Blend include approximately 125 mg of valerian extract, a combined 420 mg of chamomile, passionflower, and ashwagandha, 200 mg of L-theanine, 100 mg of GABA, 400 mg of L-tryptophan, and 100 mg of phosphatidylserine. The minimum effective dose varies by ingredient; for example, ashwagandha is effective at 300-600 mg/day, and L-theanine at 100-200 mg/day. Evening dosing may enhance sleep benefits, while daytime dosing supports stress and focus. Taking the blend with food may improve the absorption of some herbal extracts. While no specific cofactors are required, overall nutritional status may influence efficacy.

FAQs

Is the proprietary blend effective?

Evidence supports individual ingredients; proprietary blends lack direct RCTs but are likely effective due to synergistic components.

Is it safe to use long-term?

Generally yes, but monitor for side effects, especially thyroid-related with ashwagandha.

When will I see results?

Stress and focus improvements may appear within weeks; sleep and mood benefits may take longer.

Can it replace medications?

No; it is a supplement, not a substitute for prescribed treatments.

Are there any risks?

Minimal if used as directed; consult healthcare provider if on medications or with health conditions.

Research Sources

https://meonutrition.com/products/inner-calm – This is a product page for Inner Calm, a supplement containing a proprietary blend of ingredients aimed at promoting relaxation and reducing stress. The page provides information on the ingredients included in the blend and their purported benefits.
https://pubmed.ncbi.nlm.nih.gov/37004873/ – This PubMed entry links to a study or article relevant to the ingredients in the Calm Proprietary Blend. The study likely investigates the effects or mechanisms of action of one or more of the blend's components, contributing to the overall understanding of its potential benefits.
https://www.drfuhrman.com/content-image.ashx/98efbjqo4f4671dgwvza47/Calm_Biotect8_14_19.pdf – This is a document related to Calm Biotect, another supplement containing a proprietary blend. The document likely provides details on the ingredients, their dosages, and the intended benefits of the supplement, offering insights into similar formulations.
https://www.mayoclinic.org/diseases-conditions/insomnia/expert-answers/valerian/faq-20057875 – This Mayo Clinic page addresses frequently asked questions about valerian, an herb commonly used for sleep disorders. It provides evidence-based information on valerian's effectiveness, safety, and potential side effects, contributing to the understanding of valerian's role in sleep improvement.
https://www.verywellhealth.com/lemme-chill-for-anxiety-kardashian-supplement-11679408 – This Verywell Health article discusses a supplement called 'Lemme Chill,' marketed for anxiety relief. While not directly about Calm Proprietary Blend, it provides context on similar supplements and their ingredients, offering insights into the market and consumer perceptions of such products.