Carbon60 Plus 5ml EVOO Infused Fullerenes
Also known as: Carbon60 (C60) fullerenes, Buckminsterfullerenes, Fullerenes, Carbon60
Overview
Carbon60 (C60) fullerenes, also known as Buckminsterfullerenes, are spherical carbon molecules composed of 60 carbon atoms arranged in a truncated icosahedron structure. These synthetic nanomaterials, first discovered in 1985, are not naturally abundant but can be produced industrially. The 'Plus 5ml EVOO Infused' refers to C60 fullerenes dissolved in extra virgin olive oil (EVOO), a common carrier to improve bioavailability and stability. Marketed as antioxidants and potential geroprotectors, C60 fullerenes are used in supplements aiming to reduce oxidative stress and improve healthspan. They possess a unique molecular structure with high symmetry, strong radical scavenging ability, and nanoscale size. While extensive physicochemical characterization exists, human clinical evidence is limited. Animal studies show promising but mixed results, and few systematic reviews/meta-analyses exist specifically on C60 fullerenes as supplements.
Benefits
The primary benefit of C60 fullerenes is their antioxidant activity, demonstrated in vitro and in animal models, showing free radical scavenging and potential reduction in oxidative damage. One controlled animal study (mice) administering C60 fullerenes dissolved in virgin olive oil orally for 7 months showed increased lifespan compared to olive oil alone, but lifespan was similar to water-treated controls, suggesting the benefit may be from mitigating olive oil’s negative effects rather than a direct lifespan extension by C60 itself. Secondary effects include potential protective effects on healthspan parameters such as physical activity, glucose metabolism, and hematological parameters in mice without observed health deterioration. Evidence is currently limited to animal models; no robust human data are available. The lifespan extension in mice was statistically significant compared to olive oil controls but not compared to water controls, indicating modest or conditional effects.
How it works
C60 fullerenes primarily function as potent free radical scavengers due to the conjugated π-electron system of the C60 molecule, neutralizing reactive oxygen species (ROS). This antioxidant effect may reduce oxidative stress-related cellular damage, potentially influencing aging and inflammation pathways. The molecules target reactive oxygen species and free radicals, though no specific protein targets have been identified. Due to poor water solubility, EVOO infusion enhances solubility and oral bioavailability. Studies indicate low systemic absorption and tissue accumulation under environmentally relevant conditions.
Side effects
Generally, C60 fullerenes are considered non-toxic in pure form; toxicity concerns often arise from solvent residues or impurities rather than C60 itself. No well-documented common adverse effects have been observed in animal studies at tested doses. Uncommon and rare side effects are not well characterized due to limited human data. Drug interactions are not well studied; potential interactions with other antioxidants or medications metabolized via oxidative pathways are speculative. No established contraindications exist, but caution is advised due to a lack of human clinical data. The safety in pregnant or lactating women, children, and individuals with chronic diseases is unknown. It's crucial to ensure the C60 product is free from harmful solvent residues like THF, as these can pose toxicity risks.
Dosage
A minimum effective dose has not been established in humans; animal studies used doses equivalent to oral administration of C60 dissolved in 5 ml EVOO over months. There is no consensus on optimal dosage ranges; marketed products often use 5 ml EVOO infused with a specified C60 concentration. The maximum safe dose is not defined; toxicity studies suggest high doses of pure C60 are not acutely toxic, but long-term safety is unclear. Chronic daily administration was used in animal studies; no human timing data are available. EVOO infusion improves solubility and may enhance antioxidant effects compared to other solvents. Lipid-based carriers like EVOO improve absorption; water suspensions show minimal bioavailability. No required cofactors have been identified.
FAQs
Is Carbon60 Plus 5ml EVOO Infused safe for human consumption?
Animal studies suggest low toxicity, but human safety data are lacking; caution is warranted. Ensure the product is free from solvent residues.
Does it extend lifespan?
Evidence in mice shows lifespan extension compared to olive oil controls but not compared to water controls, indicating modest or conditional benefits.
How should it be taken?
Typically orally, dissolved in EVOO; dosing regimens are not standardized. Follow product-specific guidelines.
Are there any side effects?
No significant side effects reported in animal studies; human data are insufficient. Monitor for any adverse reactions.
Is the olive oil carrier beneficial or harmful?
Olive oil itself may have negative effects in some mouse strains; C60 may mitigate these effects. EVOO improves C60 absorption.
Research Sources
- https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=905985 – This paper discusses the importance of understanding the properties, behavior, and potential impacts of engineered nanomaterials, including fullerenes like C60. It highlights the need for standardized methods for characterizing these materials to ensure their safe and effective use in various applications.
- https://www.annualreviews.org/content/journals/10.1146/annurev-physchem-082423-013137?TRACK=RSS – This review provides an overview of the physical and chemical properties of fullerenes, including their unique electronic structure and reactivity. It discusses how these properties can be tailored for various applications, such as drug delivery and energy storage, emphasizing the importance of understanding their fundamental characteristics.
- https://pubs.acs.org/doi/10.1021/acsanm.4c06721 – This study investigates the potential of C60 fullerenes for biomedical applications, focusing on their antioxidant and anti-inflammatory properties. It explores how C60 can be used to protect cells from oxidative stress and inflammation, suggesting its potential as a therapeutic agent for various diseases.
- https://pubmed.ncbi.nlm.nih.gov/33849306/ – This research examines the effects of oral administration of C60 fullerenes dissolved in virgin olive oil on the lifespan and healthspan of mice. The findings suggest that C60 may increase lifespan compared to olive oil alone, and improve healthspan parameters without observed health deterioration, though the lifespan was similar to water-treated controls.
- https://pubmed.ncbi.nlm.nih.gov/18824284/ – This study assesses the toxicity of C60 fullerenes, attributing toxicity to solvent residues (THF) rather than C60 itself. The research indicates that pure C60 showed no acute toxicity in human lung cells or aquatic organisms, highlighting the importance of ensuring purity in C60 products.