Carrapichinho Extract
Also known as: Carrapichinho, African cherry, Pygeum, Pygeum africanum, Prunus africana
Overview
Carrapichinho Extract, also known as Pygeum, is derived from the bark of the *Prunus africana* tree, native to Africa. It is primarily utilized as a herbal supplement for the management of benign prostatic hyperplasia (BPH) symptoms and other related urinary tract issues. The extract is rich in bioactive compounds, including phytosterols, pentacyclic triterpenoids, and ferulic acid esters, which are believed to be responsible for its therapeutic effects. Research on Carrapichinho is well-established, with numerous clinical trials and systematic reviews consistently focusing on its efficacy in improving prostate health and alleviating urinary symptoms. It is commonly used to address lower urinary tract symptoms (LUTS) such as frequent urination, urgency, and poor urine flow.
Benefits
The most significant and well-documented benefit of Carrapichinho Extract is its ability to improve lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). This includes enhancing urine flow and reducing nocturia (nighttime urination). Meta-analyses and systematic reviews, notably a Cochrane review from 2002, indicate that Pygeum extract significantly improves urinary symptoms and flow measures compared to placebo, demonstrating moderate clinical benefit. These improvements typically become noticeable within 4 to 12 weeks of consistent use. Secondary benefits, though less extensively quantified in clinical studies, may include anti-inflammatory and potential antioxidant activities, contributing to overall prostate health. The evidence supporting its efficacy for BPH-related urinary symptoms is considered robust, based on multiple randomized controlled trials and systematic reviews.
How it works
Carrapichinho Extract exerts its effects primarily through anti-inflammatory and anti-androgenic mechanisms. It works by inhibiting the activity of the 5-alpha-reductase enzyme, which in turn reduces the levels of dihydrotestosterone (DHT), a hormone implicated in prostate enlargement. Additionally, the extract modulates prostatic cell proliferation and apoptosis, helping to regulate prostate tissue growth. It also improves microcirculation within prostate tissue, enhancing nutrient and oxygen supply. The phytosterols present in the extract play a crucial role in these actions by stabilizing cell membranes and reducing inflammatory processes. The oral bioavailability is moderate, and standardized extracts are preferred to ensure consistent delivery of active constituents.
Side effects
Carrapichinho Extract is generally considered safe and well-tolerated in clinical trials. Common side effects are rare, occurring in less than 5% of users, and typically include mild gastrointestinal discomfort (such as stomach upset or diarrhea) and headache. Uncommon side effects, observed in 1-5% of individuals, may include allergic reactions or skin rash. No significant hepatotoxicity or serious adverse events have been reported in high-quality studies. While no major drug interactions have been definitively documented, caution is advised when combining Carrapichinho Extract with anticoagulants or hormone therapies due to potential additive effects. Contraindications include a known allergy to *Prunus africana* or any related plant species. The safety of Carrapichinho Extract in pregnant or breastfeeding women has not been established, and its use is not recommended in these populations.
Dosage
Effective dosages of Carrapichinho Extract, as observed in clinical trials, typically range from 50 mg to 200 mg of standardized extract per day. Many meta-analyses and the Cochrane review frequently reference a daily dose of approximately 100 mg of a standardized extract as effective for improving BPH symptoms. The duration of treatment in studies has varied from 4 to 12 weeks, with longer-term use generally considered safe, although less extensively studied in formal trials. For consistent efficacy, it is recommended to use extracts that are standardized to contain specific percentages of key active compounds, such as phytosterols and triterpenes. The daily dose can often be taken as a single dose or divided into two doses.
FAQs
Is Carrapichinho Extract effective for prostate enlargement?
Yes, evidence from multiple studies supports its moderate effectiveness in improving urinary symptoms associated with benign prostatic hyperplasia (BPH).
How soon do benefits appear?
Benefits typically become noticeable within 4 to 12 weeks of consistent daily use, as observed in clinical trials.
Is it safe for long-term use?
Clinical data up to 12 weeks show good safety. Longer-term safety data are more limited, but no serious adverse events have been reported.
Can it replace conventional medications for BPH?
It may be used as an adjunct or alternative for mild to moderate BPH, but it should not replace prescribed therapies without medical advice.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/33021111/ – This source likely discusses research related to *Prunus africana* or its effects, potentially covering aspects of its mechanism or clinical outcomes. It contributes to the understanding of the ingredient's scientific basis.
- https://caringsunshine.com/relationships/relationship-urinary-system-and-pygeum/ – This source provides information on the relationship between the urinary system and Pygeum (*Prunus africana*), likely detailing its traditional and modern uses for urinary health and BPH symptoms.