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cassia seed

Also known as: Cassia Seed, Jue Ming Zi, Cassia tora, Cassia obtusifolia

Overview

Cassia Seed is derived from the seeds of the *Cassia* plant, primarily *Cassia obtusifolia* or *Cassia tora*, found in Asia and Africa. It has been traditionally used in Chinese medicine for treating constipation, improving vision, and as an anti-inflammatory agent. The seeds contain anthraquinones, naphthopyrone glucosides, and other bioactive compounds that are thought to contribute to its pharmacological effects. Research on Cassia Seed is still emerging, with a moderate level of studies exploring its potential health benefits. While traditional use suggests various benefits, more high-quality human trials are needed to confirm its efficacy and safety. It is available in various forms, including teas, capsules, and powders, often used in decoctions. The quality of available evidence is variable, highlighting the need for further research to establish its role in modern medicine.

Benefits

Animal studies and in vitro experiments suggest that Cassia Seed may have anti-inflammatory, anti-diabetic, and anti-atherosclerotic effects. These effects are potentially mediated through the modulation of inflammatory pathways, vascular endothelial growth factor (VEGF) signaling, and arachidonic acid metabolism. Some research indicates potential benefits for reducing blood pressure and improving liver function. However, the evidence is primarily from animal studies, and human trials are limited. The effect sizes and clinical significance in humans are not well quantified, and the time course of benefits is not established. Further research is needed to confirm these benefits in human populations and to determine the optimal conditions for its use.

How it works

Cassia Seed's mechanism of action involves the modulation of inflammatory pathways, such as TNF signaling, vascular endothelial growth factor (VEGF) signaling, and arachidonic acid metabolism. It interacts with cardiovascular, hepatic, and renal systems. Molecular targets include proto-oncogene tyrosine-protein kinase Src, transcription factor AP-1 (JUN), and mitogen-activated protein kinases. These interactions are believed to contribute to its potential anti-inflammatory, anti-diabetic, and anti-atherosclerotic effects. However, the absorption and bioavailability of its active compounds are not well studied, limiting a complete understanding of its systemic effects.

Side effects

While Cassia Seed is generally considered safe in traditional use, comprehensive safety data are lacking. Common side effects are not well documented, but potential gastrointestinal disturbances have been reported. Uncommon and rare side effects are largely unknown. There is a potential for interactions with antidiabetic and antihypertensive medications. Due to the lack of safety data, Cassia Seed is contraindicated during pregnancy and lactation. Caution is advised in patients with diabetes or hypertension. Further research is needed to fully characterize its safety profile and potential adverse effects.

Dosage

The minimum effective dose of Cassia Seed is not established, and optimal dosage ranges vary depending on the intended use. Traditionally, it is used in decoctions or as a powder, but specific dosages are not well-defined. The maximum safe dose is also not defined. Timing considerations are not specified. It is available in various forms, including capsules and teas. Absorption factors are unknown, and no required cofactors have been identified. Due to the limited research, it is important to exercise caution and consult with a healthcare professional before using Cassia Seed.

FAQs

What is Cassia Seed traditionally used for?

Cassia Seed has been traditionally used in Chinese medicine for treating constipation, improving vision, and as an anti-inflammatory agent. However, its efficacy and safety in modern contexts require further study.

Is Cassia Seed safe to use?

While traditionally used, comprehensive safety data are lacking. Potential side effects and drug interactions are not well-documented, so caution is advised, especially during pregnancy and lactation.

What are the potential benefits of Cassia Seed?

Animal studies suggest potential benefits for inflammation and metabolic health, including anti-diabetic and anti-atherosclerotic effects. However, human evidence is limited, and more research is needed.

How should Cassia Seed be taken?

The optimal timing and administration are not well established. It is available in various forms, including teas and capsules, but specific dosage recommendations are lacking. Consult with a healthcare professional before use.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC10980403/ – A network pharmacology study identified 14 active ingredients in Cassia Seed that may influence atherosclerosis through multiple pathways, including inflammation and vascular growth factor signaling. The study suggests potential mechanisms by which Cassia Seed could exert anti-atherosclerotic effects, highlighting the involvement of various biological pathways and molecular targets.
https://www.science.gov/topicpages/d/databases+pubmed+cinahl – This link directs to Science.gov's page on PubMed and CINAHL databases, which are resources for scientific and medical research. It does not provide specific information about Cassia Seed itself, but rather serves as a portal to access relevant research articles and studies.
https://pubmed.ncbi.nlm.nih.gov/36086754/ – This study likely investigates the pharmacological effects or chemical composition of Cassia Seed. Further investigation of the study is needed to determine the specific findings and relevance to the overall understanding of Cassia Seed's properties and potential health benefits.
http://repo.polkesraya.ac.id/2536/1/ICASH4_Abstract%20Book_FIX.pdf – This abstract book may contain information on Cassia Seed, potentially discussing its traditional uses or bioactive compounds. Further review of the abstract is needed to determine the specific findings and relevance to the overall understanding of Cassia Seed's properties and potential health benefits.
https://www.spandidos-publications.com/10.3892/mmr.2017.6880 – This review highlights Cassia Seed's potential anti-diabetic, hepatoprotective, and hypotensive effects, though most evidence comes from animal studies. The review summarizes the current understanding of Cassia Seed's pharmacological properties and potential therapeutic applications, emphasizing the need for more human studies to confirm these benefits.