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Cayenne Fruit Extract

Also known as: Capsaicin, Cayenne pepper, Chili pepper, Capsicum annuum extract

Overview

Capsaicin is the active compound found in chili peppers, particularly in the Capsicum annuum plant, commonly known as cayenne pepper. It is responsible for the spicy or pungent sensation associated with these peppers. As a dietary supplement, capsaicin is used for its potential benefits in weight management, metabolic health, and cardiovascular function. It primarily works by activating the TRPV1 receptor, influencing various physiological processes such as pain sensation, metabolism, and cardiovascular health. Capsaicin is available in various forms, including capsules, powders, and topical creams, with oral forms being most commonly used for metabolic and weight loss benefits. Research on capsaicin is moderately mature, with numerous studies including randomized controlled trials (RCTs) and meta-analyses providing insights into its effects.

Benefits

Capsaicin has shown potential benefits in weight loss, lipid profile improvement, and cardiovascular health. A meta-analysis found that capsaicin supplementation modestly reduces BMI, body weight, and waist circumference in overweight and obese individuals. Another meta-analysis indicated that capsaicin significantly decreases total cholesterol and LDL-C levels in patients with metabolic syndrome. Observational studies suggest that chili pepper consumption is associated with reduced all-cause and cardiovascular mortality. Subgroup analyses have shown that capsaicin can reduce triglyceride levels specifically in women. While the effect sizes are modest, the improvements in lipid profiles are clinically significant for managing metabolic syndrome. These benefits have been observed over intervention periods ranging from 4 to 12 weeks.

How it works

Capsaicin's primary mechanism of action involves activating the transient receptor potential vanilloid 1 (TRPV1) receptor. This receptor is expressed in various tissues, including the nervous system, adipose tissue, and the cardiovascular system. Activation of TRPV1 can increase energy expenditure and enhance fat oxidation, contributing to weight loss. Furthermore, it can improve cardiovascular health by reducing blood pressure and improving lipid profiles. Capsaicin is well-absorbed when ingested, and its bioavailability can be influenced by factors such as the presence of food. The interaction with the TRPV1 receptor triggers a cascade of physiological responses that influence metabolism, pain sensation, and cardiovascular function.

Side effects

Capsaicin is generally considered safe when consumed in moderate amounts, but it can cause several side effects. Common side effects include gastrointestinal discomfort such as stomach pain, diarrhea, and heartburn. Less common side effects include allergic reactions, sweating, and flushing. Rare side effects may include severe allergic reactions. Capsaicin may interact with antacids, blood thinners, and certain medications for high blood pressure and diabetes. Individuals with severe gastrointestinal issues, such as ulcers or inflammatory bowel disease, should avoid capsaicin. Pregnant or breastfeeding women should consult healthcare providers before using capsaicin supplements. It is important to start with a low dose to assess tolerance and minimize potential adverse effects.

Dosage

The minimum effective dose of capsaicin for weight loss and metabolic benefits is typically around 2-4 mg per day. For weight loss, doses ranging from 6-10 mg per day have been studied, while for lipid profile improvements, doses of 2-6 mg per day are often used. There is no established maximum safe dose, but doses above 10 mg per day may increase the risk of gastrointestinal side effects. Capsaicin can be taken with meals to reduce gastrointestinal side effects. It is available in various forms, including capsules, powders, and topical creams, with oral forms being most commonly used for metabolic and weight loss benefits. Absorption can be enhanced when taken with a meal containing healthy fats.

FAQs

Is capsaicin safe to consume?

Capsaicin is generally safe, but it can cause gastrointestinal discomfort. Start with a low dose and gradually increase as needed to assess tolerance and minimize potential side effects.

When is the best time to take capsaicin?

Taking capsaicin with meals can help reduce gastrointestinal side effects. Consistent timing can also help maintain stable levels in the body.

What results can I expect from taking capsaicin?

Modest weight loss and improvements in lipid profiles can be expected over several weeks of consistent use, in conjunction with a healthy diet and exercise.

Is capsaicin a magic bullet for weight loss?

No, capsaicin is not a magic bullet for weight loss; it should be used in conjunction with a healthy diet and exercise to achieve optimal results.

Research Sources

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-capsaicin-intake-on-weight-loss-among-overweight-and-obese-subjects-a-systematic-review-and-metaanalysis-of-randomised-controlled-trials/AF1C3A4331A35BA12CE925B0B56818B8 – This systematic review and meta-analysis of 11 RCTs with 1,046 participants found that capsaicin supplementation resulted in modest reductions in BMI, body weight, and waist circumference among overweight and obese individuals. The intervention periods ranged from 4 to 12 weeks, and the study followed PRISMA guidelines, indicating high-quality evidence despite observed heterogeneity between studies.
https://repository.rcsi.com/articles/journal_contribution/Meta-analysis_evaluating_the_impact_of_chili-pepper_intake_on_all-cause_and_cardiovascular_mortality_a_systematic_review/24249691 – This meta-analysis of 4 observational studies with 570,762 participants indicated that chili pepper consumption was associated with reduced all-cause and cardiovascular mortality. The study involved long-term follow-up, but the evidence is considered moderate-quality due to the observational nature of the included studies and high heterogeneity between them.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD004460.pub2/abstract – This Cochrane review assesses the effectiveness of topical capsaicin for chronic musculoskeletal pain in adults. While the abstract provides limited detail, Cochrane reviews are generally considered high-quality and aim to provide a comprehensive and unbiased assessment of available evidence.
https://pubmed.ncbi.nlm.nih.gov/35947382/ – This study investigates the effects of capsaicin on gut microbiota and metabolic parameters in obese mice. The findings suggest that capsaicin can modulate gut microbiota composition and improve metabolic outcomes, providing insights into the potential mechanisms underlying its beneficial effects.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.812294/full – This systematic review and meta-analysis of 9 RCTs with 461 patients with metabolic syndrome found that capsaicin supplementation significantly reduced total cholesterol and LDL-C levels. The intervention periods ranged from 4 to 12 weeks, and the study provided high-quality evidence with clear effect sizes and confidence intervals, although heterogeneity in subgroup analyses was noted.