Get Your Personalized Supplement StackSupplement Stack Quiz

CDP-Choline

Also known as: Citicholine, Cytidine Diphosphocholine

Overview

CDP-choline is a nootropic compound that is essentially a prodrug for both choline and uridine, conferring both of those molecules to the body following oral ingestion of CDP-Choline. Specifically, the CDP-choline dissociates into choline and cytidine, with the cytidine then converting into uridine. CDP-choline is one of the three choline-containing phospholipids that can be orally supplemented (the other two being Alpha-GPC and phosphatidylcholine). This supplement is catered towards preventing or treating memory impairments associated with aging due to the fact that both of the molecules it confers are neuroprotective and potentially enhance learning. While it appears to be more effective than phosphatidylcholine (PC) at this role, in part due to also increasing PC synthesis in the brain, its potency is somewhat comparable to that of Alpha-GPC. CDP-choline has some other potential uses in relation to cognition. It is commonly used as a memory enhancer in youth, but despite some rodent studies suggesting that this is possible with oral CDP-choline, there are no human studies in youth at this point in time. One study has noted an increase in attention with low dose CDP-choline (which needs to be replicated), and CDP-choline may have roles as an anti-addictive compound against both cocaine and (preliminary evidence suggests) food as well.

Benefits

CDP-choline converts into choline and cytidine upon ingestion. The cytidine then converts into uridine in the body. This process increases the availability of these neuroprotective molecules, which are believed to enhance cognitive function and memory.

How it works

CDP-choline is associated with several benefits, including enhancing memory and cognitive function, particularly in aging populations. It may also improve attention and has potential anti-addictive properties. Additionally, it is linked to neuroprotection and may aid in the synthesis of phosphatidylcholine in the brain.

Side effects

Standard dosing of CDP-choline is to take 500-2,000 mg in two divided doses (of 250-1,000 mg) usually separated by 8-12 hours, although a single daily dose is also sometimes used. A single dose of 4,000 mg does not appear to affect the blood any differently than 2,000 mg, and so it is not necessary to take such a high dose. There are some properties, such as attention-promotion or improving bioenergetics, that seem to respond exclusively or more strongly to the lower dosage range. Other properties like appetite are the opposite, and thus the ideal dosage depends somewhat on the goal.

Dosage

CDP-choline is generally considered safe, but some individuals may experience side effects such as gastrointestinal discomfort, headache, or insomnia. It is important to consult with a healthcare provider before starting any new supplement, especially for individuals with underlying health conditions or those taking other medications.

FAQs

What is CDP-Choline?

CDP-Choline is a nootropic compound that serves as a prodrug for both choline and uridine, which are important for cognitive function.

How does CDP-Choline work?

CDP-Choline works by converting into choline and cytidine in the body, which then converts into uridine, enhancing cognitive function and memory.

What are the benefits of CDP-Choline?

The benefits of CDP-Choline include improved memory and cognitive function, increased attention, neuroprotection, and potential anti-addictive properties.

What is the recommended dosage for CDP-Choline?

The recommended dosage for CDP-Choline is typically between 500-2,000 mg per day, divided into two doses.

Are there any side effects of CDP-Choline?

Some potential side effects of CDP-Choline include gastrointestinal discomfort, headache, and insomnia.