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Certified Organic Celery Extract

Also known as: Celery, celery extract, celery seed extract, Certified Organic Celery Extract, Apium graveolens

Overview

Certified Organic Celery Extract is a botanical dietary supplement derived from organically grown *Apium graveolens*, commonly known as celery. This extract is processed to concentrate its bioactive compounds, ensuring cultivation without synthetic pesticides or fertilizers. It is primarily utilized for its potential benefits in cardiovascular health, particularly blood pressure regulation, and for metabolic support, including glycemic and lipid control. The extract also exhibits hepatoprotective and anti-inflammatory properties. Key phytochemicals found in celery extract include flavonoids, phthalides (such as sedanolide and 3-n-butylphthalide), various antioxidants, and volatile oils. Research on celery extract is moderately mature, with multiple randomized controlled trials (RCTs) and meta-analyses supporting its efficacy, although study designs and extract standardization can vary.

Benefits

Celery extract offers several evidence-based benefits, primarily in cardiovascular and metabolic health. A systematic review and meta-analysis of RCTs demonstrated that celery preparations significantly reduce systolic and diastolic blood pressure in hypertensive adults, indicating a moderate effect size. This makes it particularly beneficial for individuals with hypertension. The same meta-analysis also reported improvements in fasting blood glucose levels and a reduction in total cholesterol and triglycerides, suggesting its utility in managing metabolic syndrome or type 2 diabetes. These effects are statistically significant and clinically relevant, with benefits typically observed after at least 30 days of consistent use. Beyond these primary effects, preclinical studies indicate hepatoprotective activity, with celery extract reducing markers of liver damage and protecting against chemically induced hepatotoxicity. It also exhibits significant antioxidant and anti-inflammatory effects by normalizing oxidative stress markers. Some preclinical evidence suggests neuropharmacological effects, including antidepressant and sedative properties, though human data are currently lacking for these specific benefits. Adults with hypertension, metabolic syndrome, or liver dysfunction are the populations most likely to benefit from celery extract supplementation.

How it works

Celery extract exerts its therapeutic effects through several biological pathways. Its primary mechanism for blood pressure reduction involves vasodilation, where phthalides within the extract promote smooth muscle relaxation, thereby lowering peripheral vascular resistance. The extract's antioxidant activity is attributed to its rich content of flavonoids and phenolic compounds, which scavenge free radicals and reduce oxidative stress. Celery extract also inhibits xanthine oxidase enzyme activity, which helps reduce uric acid production and associated oxidative damage. For hepatoprotection, it modulates liver enzyme activity and reduces inflammatory mediators, safeguarding hepatocytes. These actions collectively impact the cardiovascular, hepatic, metabolic, and nervous systems. Bioactive compounds like phthalides are lipophilic, suggesting that absorption may be enhanced when consumed with fat-containing meals.

Side effects

Certified Organic Celery Extract is generally considered safe, with a low incidence of adverse effects reported in clinical trials. No significant common adverse effects (occurring in >5% of users) have been reported in randomized controlled trials. Uncommon side effects (1-5%) may include mild gastrointestinal discomfort in sensitive individuals, though data on this are sparse. Rare side effects (occurring in <1% of users) are not well-documented, and no serious adverse events have been reported in high-quality studies. Regarding drug interactions, there is a potential for additive hypotensive effects when celery extract is taken concurrently with antihypertensive medications, necessitating caution and medical supervision. Contraindications include hypersensitivity or allergies to celery or other plants in the Apiaceae family (e.g., carrots, parsley, dill). Data on the safety of celery extract in pregnant or breastfeeding women are limited, and its use in these populations should be approached with caution and under medical guidance.

Dosage

For Certified Organic Celery Extract, a minimum effective dose of 500 mg/day has been identified in meta-analyses for significant effects on blood pressure and metabolic parameters. The optimal dosage range appears to be between 500–1,000 mg/day of a standardized extract. While higher doses (>1,000 mg/day) have been studied, they have not consistently shown clear additional benefits. There is no established maximum safe dose, but doses up to 1,000 mg/day have been well-tolerated in clinical trials. For optimal results, daily dosing for at least 4 weeks is recommended, as clinical benefits typically emerge after this period of consistent use. It is advisable to use standardized extracts (e.g., from seeds or aerial parts) to ensure consistent bioactive compound content. Co-administration with meals may enhance the absorption of the lipophilic components within the extract. No specific cofactors are identified as being required for its efficacy.

FAQs

Is organic celery extract more effective than conventional?

Chemical composition studies indicate no significant nutritional difference between organic and conventional celery. Therefore, if extracts are standardized for bioactive compounds, their efficacy is expected to be similar.

How soon can benefits be expected?

Clinical trials suggest that the beneficial effects of celery extract, particularly on blood pressure and metabolic parameters, typically become noticeable after at least 4 weeks of consistent daily use.

Is celery extract safe for long-term use?

While extensive long-term safety data are limited, short- to medium-term use of celery extract has been shown to be safe in clinical trials, with no serious adverse effects reported.

Can celery extract replace antihypertensive drugs?

Celery extract may serve as an adjunct therapy for blood pressure management. However, it should not replace prescribed antihypertensive medications without direct medical supervision and consultation with a healthcare professional.

Research Sources

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1597680/full – This systematic review and meta-analysis of randomized controlled trials found that celery preparations significantly reduced systolic and diastolic blood pressure, fasting blood glucose, and lipid levels in adults with hypertension or metabolic disorders. The study observed a dose-response relationship and highlighted the clinical relevance of these benefits, despite some heterogeneity in study designs.
https://www.gavinpublishers.com/article/view/content-comparison-of-organic-and-conventional-celery – This source discusses the chemical composition of organic versus conventional celery. It suggests that there is no significant nutritional difference between the two, implying that the efficacy of extracts would be similar if standardized for bioactive compounds, regardless of organic certification.
https://www.sysrevpharm.org/articles/review-on-the-pharmacological-and-health-aspects-of-apium-graveolens-or-celery-an-update.pdf – This narrative review summarizes various pharmacological studies on *Apium graveolens*. It reports on hepatoprotective, antidepressant, sedative, and cytoprotective activities observed primarily in preclinical models, indicating a broad range of potential therapeutic effects for celery extract.
https://www.nature.com/articles/s41598-020-66205-4 – This animal study investigated the effects of celery extract in hyperuricemic mice. It found that celery extract reduced markers of liver and kidney dysfunction, inhibited xanthine oxidase activity, and improved antioxidant status, supporting its potential for managing conditions related to high uric acid and oxidative stress.