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Celery Concentrate

Also known as: Celery, celery seed, celery powder, celery concentrate, Apium graveolens

Overview

Celery concentrate is a botanical supplement derived from the stalks, seeds, or whole plant of Apium graveolens. It is traditionally recognized for its potential benefits in cardiovascular and metabolic health. Its primary applications include the management of hypertension (high blood pressure), hyperglycemia (high blood sugar), and hyperlipidemia (high cholesterol and triglycerides). Key characteristics of celery concentrate include its antioxidant, anti-inflammatory, and mild diuretic properties. Research on celery concentrate is moderately mature, with an increasing number of randomized controlled trials (RCTs) and meta-analyses. While the quality of evidence is improving, it is still limited by factors such as small sample sizes, population homogeneity (primarily Asian cohorts in studies), and some methodological heterogeneity across studies. It is available in various forms, including powders and seed extracts, with varying phytochemical compositions.

Benefits

Celery concentrate offers several evidence-based benefits, primarily in cardiometabolic health. A recent systematic review and meta-analysis (2025) of randomized controlled trials (RCTs) demonstrated that celery preparations significantly reduce systolic and diastolic blood pressure, fasting plasma glucose, and triglycerides. However, this meta-analysis did not find a significant effect on total cholesterol or LDL/HDL cholesterol levels. For hypertensive patients, celery seed extract at approximately 1.34 g/day has been shown to lower blood pressure and improve lipid profiles, liver enzymes, and renal function markers. While a 12-week RCT using 750 mg/day of celery powder in type 2 diabetes mellitus (T2DM) patients did not significantly improve glycemic or lipid parameters, it did reduce body fat percentage and showed trends toward reduced oxidative stress. Beyond cardiometabolic effects, celery supplementation has also shown potential anxiolytic and antidepressant effects in hypertensive patients, leading to reductions in anxiety and depression scores. The strength of evidence for blood pressure and triglyceride reduction is moderate to high, supported by meta-analysis, while evidence for glycemic control is mixed, and anxiolytic effects are promising but require further confirmation.

How it works

Celery concentrate exerts its effects through various bioactive compounds, including flavonoids (such as apigenin), phenolic acids, and phthalides. These compounds contribute to its notable antioxidant and anti-inflammatory properties by scavenging free radicals and modulating inflammatory pathways. In terms of metabolic regulation, celery can inhibit enzymes like α-glucosidase and α-amylase, which are involved in carbohydrate digestion, thereby potentially modulating post-meal glucose absorption. Its blood pressure-lowering effects are thought to be mediated by vasodilatory mechanisms, possibly involving calcium channel blocking and nitric oxide pathways, which promote the relaxation and widening of blood vessels. The bioavailability and specific mechanisms can vary depending on the preparation, with seed extracts and powders differing in their phytochemical content and absorption profiles.

Side effects

Celery preparations generally exhibit a favorable safety profile, with no serious adverse events reported in clinical trials. Common side effects are rare and typically mild, primarily involving gastrointestinal discomfort. While no significant drug interactions have been extensively documented, caution is advised when combining celery concentrate with antihypertensive or antidiabetic medications due to the potential for additive effects, which could lead to excessively low blood pressure or blood sugar. Individuals already on these medications should consult a healthcare professional before starting celery supplementation. Contraindications are not well-defined, but individuals with known allergies to plants in the Apiaceae family (which includes carrots, parsley, and dill) should exercise caution, as cross-reactivity is possible. Pregnant and breastfeeding women should also consult their healthcare provider before use due to insufficient safety data in these populations.

Dosage

Effective dosages of celery concentrate, as observed in clinical studies, range from 750 mg/day for celery powder to 1.34 g/day for celery seed extract. It is important to note that optimal dosing and standardization of preparations are still being established, and a recent meta-analysis, while supporting benefits at these doses, calls for larger, more standardized trials to confirm precise recommendations. The timing of administration has not been extensively studied, but most trials have utilized daily dosing regimens, typically for durations of 8 to 12 weeks. Absorption of celery's active compounds may be enhanced when taken with food. Additionally, co-administration with other antioxidants could potentially potentiate its beneficial effects. There are no clearly defined upper limits or safety thresholds established for celery concentrate, but adherence to studied dosages is recommended to minimize potential, albeit rare, side effects.

FAQs

Is celery concentrate effective for blood pressure?

Yes, evidence from systematic reviews and meta-analyses supports modest but significant reductions in both systolic and diastolic blood pressure with celery concentrate supplementation.

Does it improve blood sugar control?

Evidence is mixed. A meta-analysis suggests improvement in fasting glucose, but some individual randomized controlled trials in type 2 diabetes patients have shown no significant effect on overall glycemic parameters.

Are there safety concerns?

Celery concentrate is generally considered safe with minimal reported side effects, primarily mild gastrointestinal discomfort. Serious adverse events are rare.

How long does it take to see effects?

Most studies reporting significant benefits indicate that effects typically become noticeable after 8 to 12 weeks of consistent daily supplementation.

Research Sources

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1597680/full – This systematic review and meta-analysis of RCTs found that celery preparations significantly reduced systolic and diastolic blood pressure, fasting plasma glucose, and triglycerides. It concluded that celery is a promising supplement for cardiometabolic health, though it noted limitations such as small sample sizes and heterogeneity among studies.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12321563/ – This source is likely the same as the Frontiers in Nutrition article, providing a summary of a systematic review and meta-analysis. It indicates that celery preparations significantly reduce blood pressure, fasting glucose, and triglycerides, supporting its role in cardiometabolic health.
https://onlinelibrary.wiley.com/doi/abs/10.1002/fsn3.3493 – This pilot randomized controlled trial investigated celery powder in T2DM patients. It found no significant improvement in glycemic or lipid markers but observed a reduction in body fat percentage and a trend towards lower oxidative stress, suggesting potential benefits beyond direct glucose control.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10494649/ – This source appears to be related to the pilot RCT on T2DM patients. It likely details the findings that celery powder did not significantly improve glycemic or lipid parameters but showed a reduction in body fat percentage and a trend towards reduced oxidative stress, highlighting its limited power as a pilot study.
https://journals.sagepub.com/doi/full/10.1177/1934578X251325063 – This narrative pharmacological review discusses the various effects of celery, including improvements in blood pressure, lipid profiles, and liver enzymes, as well as anxiolytic and antioxidant activities. It provides insights into the potential mechanisms of action but acknowledges the variable quality of the studies reviewed.