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Centella Asiatica Extract

Also known as: Centella asiatica (L.) Urb., Gotu kola, Asiatic pennywort, Centella asiatica

Overview

Centella asiatica, commonly known as Gotu kola or Asiatic pennywort, is a plant native to Asia and Africa, thriving in wet environments. It has a long history of use in traditional Ayurvedic and traditional Chinese medicine for its purported health benefits. The plant contains triterpenoids, which are believed to be responsible for its therapeutic effects. Primary applications include wound healing, cognitive enhancement, and skin health. Research on Centella asiatica is moderately mature, with several systematic reviews and clinical trials available. However, the quality of evidence varies, and more rigorous clinical trials are needed to confirm its efficacy and safety. It is available in various forms, including capsules and extracts.

Benefits

Centella asiatica has several evidence-based benefits. It may enhance wound healing by improving angiogenesis and collagen synthesis, as supported by systematic reviews. Some evidence suggests it may improve cognitive function and mood, although results are mixed. Potential benefits also exist for skin diseases, including acne, as indicated by systematic reviews and meta-analyses, but further research is needed. Population-specific benefits may be seen in individuals with skin conditions or those seeking cognitive enhancement. However, specific effect sizes and the time course of benefits are not well-documented, necessitating more research to quantify these aspects.

How it works

Centella asiatica exerts its effects through several biological pathways. It exhibits anti-inflammatory, anti-oxidative stress, and anti-apoptotic effects. The plant interacts with the nervous system, potentially enhancing cognitive function, and with the skin, promoting wound healing. Triterpenoids in Centella asiatica may target various molecular pathways involved in inflammation and oxidative stress. However, the absorption and bioavailability of its active compounds are not extensively studied, requiring further research to understand its pharmacokinetics fully.

Side effects

Centella asiatica is generally considered safe, but comprehensive safety data are limited. Common side effects are not well-documented but may include gastrointestinal upset. Uncommon side effects are rarely reported and may include allergic reactions. Drug interactions are possible, particularly with blood thinners and diabetes medications, warranting caution. It is contraindicated in pregnancy and breastfeeding due to insufficient safety data. Special populations, such as individuals with liver or kidney disease, should exercise caution due to a lack of data. Overall, while generally safe, monitoring for potential side effects and consulting with a healthcare provider is advised, especially when taking other medications.

Dosage

The minimum effective dose of Centella asiatica is not firmly established, but it is typically used in the range of 300-600 mg per day. Optimal dosage ranges are not well-defined and may vary based on specific health conditions. The maximum safe dose is also not established, so caution is advised at high doses. There are no specific timing recommendations, but it may be taken with meals to reduce gastrointestinal upset. Common forms include capsules or extracts. Absorption factors are not well-studied, and bioavailability may vary based on the preparation. No required cofactors have been identified.

FAQs

Should I consult a healthcare provider before using Centella asiatica?

Yes, it is advisable to consult a healthcare provider before use, especially if you are taking other medications or have underlying health conditions, to ensure it is safe for you.

Is Centella asiatica safe to use?

Centella asiatica is generally considered safe, but it's important to monitor for potential side effects and discontinue use if any adverse reactions occur. Consult a healthcare provider if you have concerns.

When is the best time to take Centella asiatica?

There is no specific timing recommended for taking Centella asiatica. It may be taken with meals to reduce the risk of gastrointestinal upset, but consistency is key.

How long does it take to see results from Centella asiatica?

The time it takes to notice benefits from Centella asiatica can vary. It may take several weeks of consistent use to observe noticeable improvements in wound healing or cognitive function.

Is Centella asiatica a substitute for medical treatment?

No, Centella asiatica is not a substitute for medical treatment. It should be used as a complementary therapy and not as a replacement for prescribed medications or medical advice.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/35328954/ – This systematic review on wound healing found that Centella asiatica may enhance wound healing by improving angiogenesis and collagen synthesis. The study suggests that C. asiatica could be a beneficial adjunct therapy for wound management due to its ability to promote tissue regeneration.
https://pubmed.ncbi.nlm.nih.gov/28878245/ – This systematic review of cognitive function and mood found mixed results regarding the effects of Centella asiatica. While some studies suggested potential benefits, the overall evidence was not conclusive, indicating the need for more rigorous research to confirm these findings.
https://biomedres.us/pdfs/BJSTR.MS.ID.009114.pdf – This systematic review and meta-analysis on acne treatment found potential benefits of Centella asiatica in managing acne. The study highlights the anti-inflammatory and wound-healing properties of C. asiatica, suggesting it could be a valuable component in acne treatment regimens, though further research is needed.
https://surgicalneurologyint.com/surgicalint-articles/centella-asiatica-effect-on-traumatic-brain-injury-a-systematic-review/ – This systematic review examines the effect of Centella asiatica on traumatic brain injury (TBI). It synthesizes findings from various studies to assess the potential neuroprotective benefits of C. asiatica in TBI recovery, focusing on its anti-inflammatory and antioxidant properties.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.568032/full – This comprehensive review explores the pharmacological properties and therapeutic applications of Centella asiatica. It details the various bioactive compounds in C. asiatica and their mechanisms of action, highlighting its potential in treating neurological disorders through its anti-oxidative stress and anti-apoptotic effects.