Celadrin(R)
Also known as: Celadrin, cetylated fatty acids (CFAs), cetyl myristoleate, cetyl myristate, cetyl palmitoleate, cetyl laurate, cetyl palmitate, cetyl oleate
Overview
Celadrin is a proprietary blend of cetylated fatty acids, synthesized through a chemical process, and not found in nature. It is primarily used as a topical anti-inflammatory and analgesic supplement aimed at alleviating symptoms associated with osteoarthritis, particularly joint pain and inflammation. The formulation is quickly absorbed through the skin and has been shown to interact with membrane receptors involved in inflammatory processes. Although research on Celadrin is at a moderate maturity level with several clinical trials supporting its usage, comprehensive systematic reviews are still lacking, indicating a need for further studies to solidify its efficacy and safety.
Benefits
Celadrin has shown several evidence-based benefits, particularly for individuals with osteoarthritis. In a controlled trial involving 40 knee OA patients, significant improvements in range of motion, stair climbing ability, and the 'up-and-go' test were documented within 30 minutes of application and sustained over a month. Another study of 28 patients across various OA locations noted roughly 12% improvements in function metrics. Additional observations included enhanced muscular endurance and postural stability. The clinical significance is noted with effect sizes ranging from 3.5% to 42% for various outcomes, indicating a strong potential for functional improvement in OA patients. Benefits have been observed as early as 30 minutes post-application, with cumulative benefits noted over a 30-day period.
How it works
Celadrin exerts its effects primarily by interacting with membrane receptors that are key players in the inflammatory response. By inhibiting thromboxane production, a compound associated with promoting inflammation and tissue damage, Celadrin aids in modulating the inflammatory processes at the cellular level. This action contributes to improving joint health and mitigating pain perception, facilitating a quicker onset of relief due to its expedited absorption through the skin.
Side effects
Celadrin is generally considered safe with no significant side effects reported in clinical trials. The available studies do not indicate any common (>5%) or significant uncommon (1-5%) side effects, and rare side effects (<1%) have not been documented. While there are no major drug interactions noted, caution is advised when combined with other anti-inflammatory medications. No specific contraindications have been established; however, individuals with sensitive skin or known allergies should proceed with caution. Moreover, due to the lack of studies involving pregnant, breastfeeding women, or children, it is recommended to approach usage in these groups cautiously.
Dosage
The recommended dosing for Celadrin involves topical application, generally advised to be applied twice daily. Although the optimal dosage ranges have not been strictly defined, the evidence suggests a consistent application regimen for the best results. While there is no established maximum safe dose, excessive use is discouraged. The topical cream is the most extensively studied formulation and is rapidly absorbed, contributing to its quick onset of effects. There are no specific cofactors required for absorption, making it user-friendly for application.
FAQs
How often should I apply Celadrin?
Typically, it is recommended to apply Celadrin twice a day for optimal results.
Can I use Celadrin with other medications?
Caution should be exercised when using Celadrin alongside other anti-inflammatory medications.
How long does it take to see benefits?
Many users report benefits as early as 30 minutes after the first application.
Is Celadrin safe for long-term use?
The current studies do not provide long-term safety data, so caution is advised for extended use.
How should I apply Celadrin?
Apply the cream topically to the affected area as needed, typically twice a day.
Research Sources
- https://www.barnys.cz/img/cms/certifikaty/Celadrin%20Study%20-%20inhibition%20of%20thromboxine%20-%202009%20Article%20Natural%20Wellness.pdf – This study focused on the inhibition of thromboxane in patients using Celadrin, showcasing its anti-inflammatory properties and beneficial effects on joint health.
- https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0072714 – A clinical trial that assessed the impact of Celadrin on osteoarthritis patients, demonstrating significant improvements in pain and functional mobility within a short duration.
- https://jmla.pitt.edu/ojs/jmla/article/download/1223/1368 – This paper reviews clinical studies involving Celadrin, concluding that while results are promising, there is a requisite for more robust, systematic investigations.
- https://www.mdpi.com/1422-0067/23/18/10384 – An article discussing the safety and efficacy of topical anti-inflammatory agents, including Celadrin, emphasizing the need for further validated research.