Chardonnay Grape Extract
Also known as: Chardonnay grape extract, Chardonnay grape seed extract, Chardonnay Grape Extract
Overview
Chardonnay grape extract is derived from the seeds and skins of Chardonnay grapes (*Vitis vinifera* L.) and is rich in polyphenols such as flavonoids and phenolic acids. It is primarily utilized for its potential cardiovascular benefits, including improving lipid profiles and reducing inflammation. Key characteristics include high levels of flavan-3-ols and other phenolic compounds. The research surrounding Chardonnay grape extract is still emerging, with some human trials conducted but limited large-scale studies. The quality of the existing evidence is moderate, comprising promising animal studies and small-scale human trials, indicating a need for further rigorous research to validate its effects in broader populations.
Benefits
Chardonnay grape extract has demonstrated several evidence-based benefits. Significant reductions in total, VLDL, and LDL cholesterol were observed in hamsters supplemented with Chardonnay grape seed flour. Furthermore, human trials indicated improved fasting glucose and insulin sensitivity in participants using Chardonnay marc blends. Secondary effects include observed anti-inflammatory and antiobesity benefits in animal studies. These positive outcomes suggest potential advantages for individuals with hyperlipidemia or those at risk for cardiovascular disease. However, the variability of effect sizes across studies highlights the need for more comprehensive data to establish strong clinical significance.
How it works
Chardonnay grape extract primarily functions by modulating lipid metabolism, enhancing insulin sensitivity, and exerting anti-inflammatory effects. It impacts cardiovascular and metabolic systems through the influence of polyphenols on genes associated with cholesterol and bile acid synthesis. While the absorption and bioavailability data remain limited, polyphenols are known to have variable rates of absorption, which may be influenced by dietary factors.
Side effects
Chardonnay grape extract is generally considered safe, but comprehensive long-term studies are lacking. Common side effects are not well-documented; however, gastrointestinal upset may occur in a small percentage of users. There are potential concerns regarding interactions with anticoagulant medications due to its polyphenol content. No specific contraindications are established, but caution is advised for pregnant or breastfeeding individuals due to insufficient data. Additionally, individuals with bleeding disorders should approach this supplementation cautiously owing to its effects on blood properties.
Dosage
Dosage recommendations for Chardonnay grape extract vary, as a minimum effective dose has not been established. Typical supplementation involves extracts or seed flours with suggested daily intakes measured in grams. No maximum safe dose is well-defined in the literature. Specific timing considerations are absent; however, taking the extract with food may enhance absorption. No cofactors are required for efficacy. Therefore, consulting available studies for tailored dosage advice is essential.
FAQs
Is Chardonnay grape extract safe to take?
Generally, yes, but monitor for gastrointestinal issues and consult a healthcare provider, especially if on medication.
When should I take it for the best results?
There are no specific timing recommendations, but taking it with meals may improve absorption.
What benefits can I expect?
Possible improvements in cholesterol and glucose regulation, particularly for those with cardiovascular risk.
Can it replace my medication?
No, it should not be viewed as a substitute for prescribed medications; consult a healthcare provider before use.
Are there any interactions with medications?
Yes, particularly with anticoagulants; consult with a healthcare provider if you're on such medications.
Research Sources
- https://escholarship.org/content/qt33j785q8/qt33j785q8_noSplash_8fdc65a894954a2c968fa45f8b362967.pdf – This randomized, double-blinded crossover trial involved 27 participants and examined the impact of Chardonnay marc blends on glucose regulation and inflammatory markers over 16 weeks, revealing promising results but limited by a small sample size.
- https://pubmed.ncbi.nlm.nih.gov/24517872/ – An animal study demonstrated that male Golden Syrian hamsters displayed reduced cholesterol levels and antiobesity effects with Chardonnay grape seed flour supplementation, indicating potential metabolic benefits that require further validation in human studies.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1187842/full – This review provided insights into the cardiovascular benefits of grape polyphenols, including those from Chardonnay, though it highlighted the need for more specific studies focused on Chardonnay grape extract to reinforce findings.
- https://pubmed.ncbi.nlm.nih.gov/31902933/ – A focused investigation showcasing the metabolic advantages of grape polyphenols, emphasizing positive cardiovascular outcomes, although specific findings relating to Chardonnay extract were limited.
- https://digital.csic.es/bitstream/10261/280320/1/grapemeta.pdf – This meta-analysis reviewed grape-derived polyphenols, noting their potential health benefits while emphasizing the variability and limitations of existing specific evidence related to Chardonnay.
