Chaste Tree Fruit Powder
Also known as: Chaste tree, Chasteberry, Vitex, Chaste fruit, Agnus castus, *Vitex agnus-castus*
Overview
Vitex agnus-castus, commonly known as chaste tree or chasteberry, is a plant native to the Mediterranean region, whose fruit is utilized in herbal medicine. This herbal supplement is primarily recognized for its ability to alleviate symptoms of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). The active compounds in chaste tree include flavonoids and iridoids, which are believed to influence hormonal balance by affecting the endocrine system. Research on chaste tree is moderate in maturity, with several randomized controlled trials (RCTs) and meta-analyses indicating positive outcomes for PMS symptom relief, though variability exists in study quality. Standardized extracts are preferred in supplementation to ensure consistent dosage and efficacy.
Benefits
Chaste tree extracts have demonstrated significant benefits for women experiencing PMS, with one meta-analysis indicating a 2.57-fold increased likelihood of symptom remission compared to placebo (95% CI 1.52-4.35). Secondary benefits also suggest potential effectiveness for premenstrual dysphoric disorder (PMDD) and latent hyperprolactinemia. Clinical studies have reported significant improvements in specific PMS symptoms such as irritability, mood alterations, and headaches, particularly after several menstrual cycles of consistent use. The overall evidence quality is generally positive, with a notable number of studies showing beneficial outcomes, although study heterogeneity limits the definitiveness of findings.
How it works
Chaste tree is believed to modulate hormonal balance by influencing dopamine and serotonin pathways, which may subsequently affect prolactin levels. This interaction with the endocrine system is thought to help mitigate hormonal fluctuations associated with PMS. Although the precise molecular targets remain largely unidentified, the modulation of neurotransmitters appears to play a pivotal role in its mechanism of action.
Side effects
Chaste tree is generally well-tolerated, although mild side effects can occur in some users. Common adverse effects (greater than 5% incidence) include gastrointestinal discomfort and headaches. Less frequent side effects (1-5%) may include allergic reactions and skin rashes, while rare side effects are not well-documented. Caution should be exercised in individuals on dopamine antagonists or hormonal therapies due to potential interactions. Due to a lack of safety data, its use is contraindicated during pregnancy and breastfeeding, and special considerations should be noted for individuals with hormonal-sensitive conditions.
Dosage
The typical recommended dosage of standardized chaste tree extract ranges from 20 to 40 mg per day, with a minimum effective dose of around 20 mg. While the maximum safe dose has not been well-defined, it is generally advised not to exceed 40 mg per day. Users are encouraged to take the supplement once daily, starting at the beginning of the menstrual cycle to optimize effects. Standardized extracts are preferred over raw fruit for consistent potency, and varying bioavailability may influence effectiveness depending on the extract preparation.
FAQs
How long does it take to see results from chaste tree?
Many users may need to take chaste tree for several menstrual cycles before noticing significant benefits.
Is chaste tree safe during pregnancy?
Chaste tree is not recommended during pregnancy or breastfeeding due to insufficient safety data.
When is the best time to take chaste tree?
It is ideal to start taking chaste tree at the beginning of the menstrual cycle for optimal effect.
What are the expected outcomes when using chaste tree?
Many users report significant reductions in PMS symptoms, such as irritability and mood changes.
Can chaste tree be used for quick relief?
Chaste tree is not a quick fix; consistent use over several cycles is typically required for best results.
Research Sources
- https://drtorihudson.com/botanicals/chaste-tree-effective-for-pms-in-meta-analysis/ – This meta-analysis review of multiple studies highlighted that chaste tree extracts significantly reduce PMS symptoms, resulting in a relative risk of 2.57 for symptom remission, indicating strong potential for therapeutic use.
- https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0032-1327831 – A systematic review of thirteen RCTs focusing on PMS symptoms found that chaste tree was superior to placebo for PMS relief in most trials, although the studies showed considerable methodological variability.
- https://pubmed.ncbi.nlm.nih.gov/31780016/ – Research presented indicated that chaste tree extract (ZE 440) significantly improved PMS symptoms after three menstrual cycles, with a responder rate of 52% compared to 24% in the placebo group.
- https://womensmentalhealth.org/posts/chasteberry-for-pms-and-pmdd/ – This article summarizes evidence supporting the use of chasteberry for PMS and PMDD, indicating symptom relief and enhanced quality of life, affirming its role as a potential adjunct therapy.
