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Chrysanthemum Extract

Also known as: Chrysanthemum, Ju Hua, Chrysanthemum trifurcatum, Chrysanthemum extract, Chrysanthemum morifolium

Overview

Chrysanthemum extract is derived from various species of the Chrysanthemum genus, particularly *Chrysanthemum morifolium* and *Chrysanthemum trifurcatum*. These plants, commonly used ornamentally and in traditional medicine, are recognized for their potential health benefits, including antioxidant, anti-inflammatory, and antihypolipidemic properties. The extract contains various bioactive compounds such as flavonoids, alkaloids, and other secondary metabolites that contribute to its therapeutic effects. While there is moderate research maturity regarding its pharmacological effects, the majority focus on in vitro and animal studies, with limited human clinical trials. Chrysanthemum is often consumed as a tea or in capsule form, although standardization of dosing remains absent due to variations in extraction methods and bioavailability.

Benefits

Chrysanthemum extract is associated with several evidence-based health benefits. Notably, it exhibits strong antioxidant activity, which enhances serum antioxidant status and helps in scavenging free radicals, as shown in various studies. Additionally, its anti-inflammatory and analgesic effects are attributed to flavonoid compounds, with animal studies revealing significant pain-relieving properties. Its hypolipidemic effects are notable in individuals with high-fat diets, attributed to the extract's ability to activate the AMPK pathway, which helps in lowering blood lipid levels. However, data concerning its efficacy in human populations remains limited, highlighting the need for further research to better understand its clinical significance.

How it works

Chrysanthemum extract works primarily through its bioactive flavonoids that interact with various biological pathways. These compounds exhibit antioxidant properties by scavenging free radicals, thereby mitigating oxidative stress. They also inhibit cyclooxygenase enzymes, which leads to a reduction in inflammation and pain. Furthermore, chrysanthemum flavonoids may stimulate the AMPK pathway, which regulates energy metabolism and can potentially lower lipid production and enhance lipid utilization. Current understanding of the extract's bioavailability and human absorption remains limited, warranting more research.

Side effects

Chrysanthemum extract is generally considered safe when used as part of traditional herbal remedies. Common side effects have not been extensively documented but may include gastrointestinal upset in a small proportion of users. Allergic reactions, though rarer, have been noted among individuals sensitive to plants in the Asteraceae family. Significant interactions may occur with anticoagulant medications due to its anti-inflammatory properties, warranting caution. Pregnant and breastfeeding individuals are advised to avoid use due to insufficient safety data. Overall, while the extract has a favorable safety profile, individuals should monitor for any adverse reactions, particularly if they have preexisting allergies or are taking other medications.

Dosage

The optimal dosage of chrysanthemum extract is not well-defined, as traditional use typically does not adhere to standardized dosing protocols. Generally, recommendations range widely based on preparation methods, with common forms being tea or capsules. Given the variability in extraction methods, a minimum effective dose has not been established for specific health benefits. As a precaution, individuals should be mindful of their consumption levels, especially at high doses due to potential side effects. Typically, the lack of extensive human dosing studies necessitates a cautious approach, considering both individual responses and overall health status.

FAQs

Is chrysanthemum extract safe?

Chrysanthemum extract is generally considered safe for most people; however, it can cause allergic reactions in sensitive individuals.

What are the benefits of chrysanthemum extract?

Chrysanthemum extract may provide antioxidant support, reduce inflammation, and help lower lipid levels, especially for those with high-fat diets.

How should I take chrysanthemum extract?

Chrysanthemum extract can be consumed as tea or in capsule form; there are no specific timing recommendations for its use.

Are there any drug interactions?

Yes, there may be interactions with anticoagulants due to its anti-inflammatory effects, so caution is advised.

What should I know about dosage?

There is no established standard dosage for chrysanthemum extract; individual responses may vary widely.

Research Sources

https://pdfs.semanticscholar.org/9889/dff13c76d0839463dd4ea6a01d802e9d80f1.pdf – This study examined the analgesic and anti-inflammatory effects of chrysanthemum trifurcatum utilizing animal models, highlighting the involvement of flavonoids and alkaloids. Although the results were promising, they emphasized the need for human trials.
https://pubmed.ncbi.nlm.nih.gov/36677639/ – Conducted on 37 healthy adults, this research analyzed *Chrysanthemum morifolium*'s chemical constituents. It noted antioxidant potentials and improvements in postprandial glucose levels, but acknowledged limitations like small sample sizes.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.952588/full – This analysis explored the hypolipidemic effects of chrysanthemum flavonoids, demonstrating their role in activating the AMPK pathway in both in vivo and in vitro studies. The study called for further investigation into human relevancy.
https://www.jvwu.ac.in/2018-19.pdf – This document provides insights into the traditional uses of chrysanthemum and presents various pharmacological actions noted, although the specifics on study methodologies were not detailed.
https://journals.lww.com/ahm/fulltext/2024/03000/pharmacological_effects_of_volatile_oil_from.7.aspx – This article reviews the pharmacological effects of volatile oils from chrysanthemum, noting the extract's potential therapeutic applications while emphasizing the necessity of comprehensive clinical studies to substantiate findings.