Cindura
Also known as: *Garcinia mangostana*, *Cinnamomum tamala*, CinDura®, LI80020F4, Mangosteen fruit rind extract, Indian bay leaf extract, Garcinia mangostana and Cinnamomum tamala Extracts
Overview
CinDura® is a proprietary blend of extracts derived from the fruit rind of *Garcinia mangostana* and the leaves of *Cinnamomum tamala*. These botanical sources are recognized for their potential health benefits, particularly in enhancing physical performance and muscle strength. CinDura® has garnered attention due to its synergistic properties that may boost nitric oxide production, promote mitochondrial biogenesis, and encourage protein expressions related to muscle growth. This supplement is primarily marketed toward resistance-trained individuals looking to augment their physical performance. Research into CinDura® is still emerging, with key studies indicating beneficial effects supported by in vitro, in vivo, and human clinical trials, showcasing a promising avenue for fitness enthusiasts and athletes seeking ergogenic aids.
Benefits
CinDura® has demonstrated significant effects in enhancing muscle strength and physical performance, particularly in resistance-trained adult males. Controlled studies have reported improvements in grip strength and swimming endurance in animal models, while human studies have confirmed increases in overall muscle strength after supplementation. Specifically, notable outcomes include enhanced myogenic differentiation, increased mitochondrial biogenesis, and regulation of vital proteins like mTOR, critical for muscle growth. Evidence shows that these benefits lead to clinically significant improvements in physical performance, with statistical significance indicated by p-values less than 0.05. Although primarily observed in athlete populations, the underlying mechanisms suggest potential benefits for various groups looking to improve muscular strength and endurance.
How it works
CinDura® operates by enhancing nitric oxide production, which plays a vital role in vascular health and muscle performance. This blend activates key biological pathways, including mitochondrial biogenesis and mTOR signaling, crucial in myogenesis. By promoting these pathways, CinDura® facilitates increased protein synthesis in muscle cells and improved energy metabolism, substantially impacting muscle growth and strength. Additionally, it aids in mitigating oxidative stress, thereby protecting mitochondria from damage and sustaining their function during high-intensity activity.
Side effects
Available studies indicate that CinDura® is well-tolerated, with no significant adverse effects reported in clinical trials. There are no documented common side effects occurring in over 5% of the population, nor uncommon or rare side effects identified. However, caution is warranted due to limited data on long-term use and specific populations like pregnant women or those with chronic conditions. No interactions with medications or specific contraindications have been established, reinforcing the need for further investigation to confirm comprehensive safety profiles across diverse groups and applications.
Dosage
Based on animal studies, the minimum effective dose for CinDura® appears to be 75 mg/kg body weight per day. Optimal dosages for human use are less clearly defined in the literature, but varying doses of 75, 150, and 300 mg/kg have shown effectiveness in preclinical studies. Currently, the maximum safe dose has not been determined, and specific timing for intake remains undefined. The extracts are intended for oral administration, but more research is necessary to elucidate absorption characteristics and identify any required cofactors for enhanced efficacy.
FAQs
What are the main benefits of CinDura®?
CinDura® primarily enhances muscle strength and physical performance, particularly in resistance-trained individuals.
Are there any side effects associated with CinDura®?
Currently, no significant side effects have been reported, but long-term safety data is limited.
What is the recommended dosage for CinDura®?
Animal studies suggest a minimum effective dose of 75 mg/kg body weight, but specific human dosages are not well-established.
How does CinDura® work in the body?
It enhances nitric oxide production and stimulates pathways related to muscle growth and mitochondrial function.
Is there any research supporting the effectiveness of CinDura®?
Yes, evidence from recent clinical studies indicates significant benefits for muscle strength and performance.
Research Sources
- https://foodandnutritionresearch.net/index.php/fnr/article/view/9750 – This peer-reviewed article presents a study on the effects of CinDura® on muscle strength and performance, highlighting significant improvements in resistance-trained individuals after supplementation over a 28-day period.
- https://pubmed.ncbi.nlm.nih.gov/38650773/ – The study evaluates the synergistic effects of *Garcinia mangostana* and *Cinnamomum tamala* extracts, demonstrating notable increases in physical performance metrics and mitochondrial function in both animal and human subjects.
