Cinnamomum zeylanicum extract
Also known as: Ceylon cinnamon, true cinnamon, Cinnamomum zeylanicum
Overview
Cinnamomum zeylanicum, commonly known as Ceylon cinnamon, is a plant native to Sri Lanka, prized for its culinary and medicinal properties. As a dietary supplement, it's primarily used for managing blood sugar levels, reducing inflammation, and improving cardiovascular health. The active compounds in Ceylon cinnamon are believed to influence glucose metabolism and inflammatory pathways. It is available in various forms, including capsules, powders, and extracts. While research shows promise, particularly in blood sugar management and anti-inflammatory effects, more high-quality human trials are needed to confirm its efficacy and safety. It is generally considered safe, but caution is advised for individuals with diabetes due to its potential to lower blood sugar levels. The research maturity level is moderate, with a growing body of evidence from systematic reviews and meta-analyses.
Benefits
Cinnamomum zeylanicum offers several potential health benefits, primarily in blood sugar management, inflammation reduction, and cardiovascular health. Studies suggest it may help reduce fasting blood glucose levels and improve insulin sensitivity, particularly in individuals with type 2 diabetes, although more research is needed to confirm these findings. Cinnamon supplementation has also been shown to decrease serum C-reactive protein (CRP) levels, indicating anti-inflammatory effects, with a significant weighted mean difference of -0.81 mg/L observed in one meta-analysis. Additionally, it may help lower blood pressure in type 2 diabetic patients. Some evidence also suggests that cinnamon can aid in reducing body weight and body mass index (BMI), and enhance antioxidant markers, potentially reducing oxidative stress. Benefits may be observed within several weeks to months of consistent supplementation.
How it works
Cinnamomum zeylanicum affects glucose metabolism by inhibiting enzymes like α-amylase and α-glucosidase, enhancing insulin sensitivity, and stimulating glucose uptake. It influences the digestive system by slowing carbohydrate absorption and the endocrine system by improving insulin function. Key molecular targets include insulin receptors and glucose transporters. The bioavailability of cinnamon's active compounds can vary based on the form of supplementation. These mechanisms contribute to its potential benefits in managing blood sugar levels and improving metabolic health. Further research is needed to fully elucidate all the pathways involved.
Side effects
Cinnamomum zeylanicum is generally considered safe with no significant toxic effects reported in most studies. Common side effects are rare, but may include gastrointestinal discomfort or allergic reactions in sensitive individuals. Potential drug interactions exist with diabetes medications due to its effects on blood sugar, necessitating careful monitoring in diabetic patients. High doses may be contraindicated in pregnancy due to potential effects on uterine contractions. Caution is advised in diabetic patients due to potential hypoglycemic effects. While uncommon and rare side effects are not well-documented, it's important to adhere to recommended dosages to minimize any potential adverse reactions. Individuals with pre-existing conditions or those taking medications should consult with a healthcare provider before using Cinnamomum zeylanicum.
Dosage
The minimum effective dose of Cinnamomum zeylanicum is typically around 1-3 grams per day. The optimal dosage range is 1-6 grams per day, depending on the specific health goal. It is generally considered safe up to 6 grams per day, though higher doses may increase the risk of side effects. It is best taken with meals to enhance absorption. Capsules or powder forms are common. Bioavailability may be enhanced with food intake. No specific cofactors are required. Individuals should start with a lower dose and gradually increase it to assess tolerance and effectiveness. It is important to consult with a healthcare provider to determine the appropriate dosage for individual needs and health conditions.
FAQs
Is Cinnamomum zeylanicum safe?
Generally safe, but monitor blood sugar levels if diabetic and consult a healthcare provider before use, especially if you have pre-existing conditions or are taking medications.
When is the best time to take Cinnamomum zeylanicum?
It is best taken with meals to enhance absorption and minimize potential gastrointestinal discomfort.
How long does it take to see results?
You may see improvements in blood sugar control and inflammation within several weeks of consistent supplementation, but individual results may vary.
Can Cinnamomum zeylanicum replace medical treatment?
No, it is not a replacement for medical treatment. Consult a healthcare provider before use, especially if you have a medical condition or are taking medications.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/22671971/ – This systematic review evaluated the efficacy and safety of Cinnamomum zeylanicum in diabetes management. It highlighted potential benefits in reducing fasting blood glucose and improving insulin sensitivity, though no human studies were included, indicating a need for further research in human populations.
- https://pubmed.ncbi.nlm.nih.gov/30670254/ – This meta-analysis found that cinnamon supplementation significantly reduced serum CRP levels, indicating anti-inflammatory effects. The analysis included six RCTs with a total of 285 participants, suggesting a moderate level of evidence for its anti-inflammatory properties.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.790901/full – This review assessed the safety of cinnamon supplementation, finding no significant adverse effects. It also noted improvements in liver enzyme levels in diabetic patients, supporting its potential use as a safe adjunct therapy for diabetes management.
- https://pubmed.ncbi.nlm.nih.gov/31800140/ – A systematic review and meta-analysis found that cinnamon supplementation can reduce body weight and BMI. However, the authors noted that more long-term studies are needed to confirm these findings and to determine the optimal dosage and duration of supplementation.
- https://journals.viamedica.pl/clinical_diabetology/article/view/67683 – Cinnamon was shown to significantly reduce systolic and diastolic blood pressure in type 2 diabetic patients. This meta-analysis included five RCTs with 332 participants, providing evidence for its potential role in managing blood pressure in diabetic individuals.
