Cissis Quadrangularis Extract
Also known as: Cissus quadrangularis L., Veldt Grape, Adamant Creeper, Hadjod, Cissus quadrangularis
Overview
*Cissus quadrangularis* is a succulent vine belonging to the Vitaceae family, native to tropical and subtropical regions. Traditionally, it has been utilized in various herbal remedies for ailments such as bone fractures, hemorrhoids, obesity, diabetes, and inflammatory diseases. Its composition is rich in flavonoids, triterpenoids, phytosterols, glycosides, and essential minerals including calcium, iron, copper, zinc, and potassium. Although numerous studies and clinical trials support its therapeutic potentials, particularly in bone health and weight management, higher quality research is required for definitive conclusions on its efficacy and safety. The varying quality of available evidence necessitates careful interpretation and further investigation into its applications in modern medicine.
Benefits
[{"benefit":"Bone Health","evidence_strength":"Moderate","summary":"Significant benefits in reducing bone pain and aiding in bone fracture healing have been reported. A systematic review indicated it may aid in fracture recovery, warranting further high-quality studies."},{"benefit":"Weight Management","evidence_strength":"High","summary":"Combination products containing *Cissus quadrangularis* have shown superior effects compared to placebo in decreasing body weight (mean difference of -5.19 kg), LDL, triglycerides, and total cholesterol."},{"benefit":"Anti-inflammatory and Antioxidant Effects","evidence_strength":"Moderate","summary":"Exhibits anti-inflammatory, antioxidant, and antimicrobial properties that may benefit various health conditions."},{"benefit":"Anti-diabetic Effects","evidence_strength":"Emerging","summary":"The extract has shown anti-hyperglycemic effects by regulating gluconeogenesis, which may benefit individuals with type 2 diabetes."}]
How it works
*Cissus quadrangularis* operates through several biological mechanisms including anti-inflammatory and antioxidant actions. It interacts with the skeletal system to promote bone healing and reduce pain, while affecting metabolic pathways that improve lipid profiles and reduce blood sugar levels. Specifically, it inhibits gluconeogenesis and oxidative stress factors in diabetic models, promoting overall health benefits.
Side effects
{"overall_safety":"Generally considered safe with no serious adverse effects reported.","common_side_effects":"No commonly reported side effects (>5%) in reviewed studies.","uncommon_side_effects":"No specific uncommon side effects (1-5%) identified.","rare_side_effects":"No rare side effects (<1%) observed in literature.","drug_interactions":"Limited information available; caution is advised when combined with medications impacting bone metabolism or blood sugar.","contraindications":"Use with caution in pregnant or breastfeeding women due to insufficient safety data.","special_population":"Individuals with diabetes or osteoporosis should consult healthcare providers prior to use."}
Dosage
{"minimum_effective_dose":"Typically ranges from 500 mg to 3 g per day depending on the condition.","optimal_dosage":"For weight and bone health, doses yielding significant results are in the range of 1-3 grams.","maximum_safe_dose":"No established maximum safe dosage; doses up to 3 g have been tolerated.","timing":"Best taken with meals to potentially enhance bioavailability.","form_specific_recommendations":"Capsules or tablets are common forms of supplementation.","absorption_factors":"Bioavailability may be improved when consumed with food, though detailed absorption factors are not well-documented.","required_cofactors":"No specific cofactors are required for efficacy, but hydration and a balanced diet are advised."}
FAQs
Is *Cissus quadrangularis* safe?
Generally safe, but long-term safety and interactions need further research.
What’s the best way to take it?
No specific timing is advised; taking it with meals may improve absorption.
When can I expect to see results?
Improvements in weight management and bone health can appear in several weeks to months.
Can it treat hemorrhoids effectively?
It is not a cure-all; its efficacy for hemorrhoids is comparable to conventional treatments.
Research Sources
- https://he01.tci-thaijo.org/index.php/IJPS/article/view/18421 – A systematic review highlighted *Cissus quadrangularis*’s inefficacy in significantly improving outcomes for hemorrhoid treatment compared to standard therapies.
- https://pubmed.ncbi.nlm.nih.gov/28165166/ – This study confirmed significant benefits of *Cissus quadrangularis* in bone pain and weight management, showing no serious adverse effects in a diverse patient population.
- https://www.semanticscholar.org/paper/Efficacy-and-Safety-of-Cissus-quadrangularis-L.-in-Sawangjit-Puttarak/1cbd8643f6bef55572622106d41d116b26343041 – Review of clinical data demonstrated important weight and lipid management benefits from *Cissus quadrangularis*, reinforcing its promising role in dietary supplements.
- https://www.microbiochemjournal.com/articles/ijcmbt-aid1016.php – Findings from this review indicate that *Cissus quadrangularis* extracts hold potential in managing oxidative stress, particularly in diabetes models.
- https://onlinelibrary.wiley.com/doi/10.1002/ptr.5783 – Reported effects include the regulation of metabolic pathways affected by *Cissus quadrangularis*, signaling its broad therapeutic application.
