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Cissus Quandrangularis Extract

Also known as: Cissus quadrangularis L., Veldt grape, Devil's Backbone, Hadjod, Cissus quadrangularis

Overview

Cissus quadrangularis is a perennial plant from the Vitaceae family, traditionally used in Ayurvedic and folk medicine for bone health, fracture healing, and reducing inflammation. The extract, derived from the plant's stem, contains bioactive compounds like flavonoids, phytosterols, and minerals such as calcium and zinc. It is commonly used as a supplement to support bone healing, reduce inflammation, and aid in weight management. While research includes clinical trials and systematic reviews, the evidence base is still limited and varies in quality. It is available in various forms, including powders and capsules, and is often standardized to ensure consistent bioactive content.

Benefits

Clinical evidence suggests Cissus quadrangularis may accelerate fracture healing and improve bone regeneration due to its anabolic effects on bone metabolism and mineralization. It also exhibits anti-inflammatory properties, potentially reducing pain and swelling in musculoskeletal conditions. Some studies report modest benefits in reducing body weight and improving metabolic parameters, likely due to its antioxidant and anti-obesity effects. Meta-analyses indicate Cissus quadrangularis is as effective as conventional treatments for hemorrhoids. The presence of flavonoids and other phytochemicals contributes to antioxidant effects, which may support overall cellular health. Effect sizes vary across studies, and further validation is needed in larger trials.

How it works

Cissus quadrangularis stimulates osteoblast activity and collagen synthesis, enhancing bone formation and mineralization. It modulates inflammatory mediators, reducing cytokine production and oxidative stress. Flavonoids and phytosterols scavenge free radicals, protecting tissues from oxidative damage. The extract may influence lipid metabolism and adipogenesis, contributing to weight management effects. Bioavailability is influenced by the extract's phytochemical composition, with absorption potentially enhanced by standardization and formulation methods.

Side effects

Cissus quadrangularis is generally regarded as safe when used in recommended doses, with a good tolerability profile in clinical studies. Mild gastrointestinal discomfort has been occasionally reported. No serious adverse events have been consistently linked to Cissus quadrangularis supplementation. Due to limited data, caution is advised when combined with anticoagulants or anti-inflammatory drugs due to potential additive effects. Insufficient data exists for use during pregnancy and lactation, and caution is advised in patients with known allergies to Vitaceae family plants.

Dosage

Clinical trials have used doses of Cissus quadrangularis ranging from 300 mg to 3,000 mg daily, often standardized to specific bioactive constituents. A common dosage in bone healing and anti-inflammatory studies is approximately 500–1,000 mg twice daily. The maximum safe dose is not well established, but doses up to 3,000 mg daily have been used without significant adverse effects. It is typically administered with meals to enhance absorption and reduce gastrointestinal side effects. Standardized extracts (powder, capsules) are preferred for consistent bioactive content.

FAQs

Is Cissus quadrangularis effective for bone healing?

Evidence supports accelerated fracture healing and improved bone regeneration in humans.

Can it help with weight loss?

Some studies show modest benefits, but it should not replace conventional weight management strategies.

Is it safe long-term?

Short- to medium-term use appears safe; long-term safety data are limited.

When should I take it?

Usually with meals, twice daily.

Are there any drug interactions?

Limited evidence; consult healthcare provider if on blood thinners or anti-inflammatory medications.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/28165166/ – This systematic review and meta-analysis examined the efficacy and safety of Cissus quadrangularis in clinical use. It found evidence supporting its use in bone healing, anti-inflammatory applications, and metabolic benefits, while highlighting the need for more large-scale randomized controlled trials to solidify these findings due to the heterogeneity of included studies.
https://onlinelibrary.wiley.com/doi/10.1002/ptr.5783 – This article likely provides a detailed review of the pharmacological properties of Cissus quadrangularis. It likely covers its traditional uses, chemical composition, and potential therapeutic applications, emphasizing the need for further research to validate its efficacy and safety in various clinical settings.
https://www.ncbi.nlm.nih.gov/books/NBK77950/ – This resource from NCBI Bookshelf likely offers a comprehensive overview of Cissus quadrangularis, including its botany, traditional uses, and pharmacological properties. It may provide evidence-based information on its safety and efficacy, while also highlighting areas where further research is needed to fully understand its potential benefits and risks.
https://he01.tci-thaijo.org/index.php/IJPS/article/view/18421 – This meta-analysis of RCTs examined the effectiveness of Cissus quadrangularis in hemorrhoid treatment. The study found no significant difference between Cissus and conventional treatments, suggesting comparable efficacy. The methodological quality was high, but the scope was limited by the small number of studies and regional focus on Thailand.
https://www.microbiochemjournal.com/fulltext/ijcmbt/ijcmbt-aid1016.php – This review summarizes the pharmacological efficacy of Cissus quadrangularis, covering its antioxidant, anti-inflammatory, bone healing, and metabolic effects. It draws from preclinical and clinical studies, highlighting the need for more randomized controlled trials to confirm these findings. The review is useful for mechanistic insights but lacks a systematic methodology.

Score: 83/100