Get Your Personalized Supplement StackSupplement Stack Quiz

Citrus Bergamot

Also known as: Citrus bergamia, Bergamot, Bergamot Orange

Overview

Citrus bergamia, commonly known as Bergamot, is a citrus fruit primarily cultivated in the Calabria region of Italy. Its extract is rich in polyphenols, which are believed to contribute to its health benefits, and is often used as a nutraceutical. Bergamot is primarily used for its potential effects on lipid profiles and cardiovascular health. The fruit is characterized by its distinctive citrus flavor and aroma, making its extracts a popular ingredient in dietary supplements. Research on bergamot is growing, with several systematic reviews and meta-analyses available, though the evidence is not yet robust due to variability in study designs and quality. It is available in various forms, including capsules and extracts.

Benefits

Bergamot supplementation has been shown to significantly decrease total cholesterol, LDL cholesterol, and triglycerides, while increasing HDL cholesterol. A meta-analysis reported decreases in total cholesterol by approximately 63.60 mg/dL, LDL cholesterol by 55.43 mg/dL, and triglycerides by 74.72 mg/dL, with an increase in HDL cholesterol by 5.78 mg/dL. Some studies suggest improvements in muscle strength and function, though the evidence is less robust. Bergamot may be particularly beneficial for individuals with dyslipidemia, especially those intolerant to statins. The time course for these benefits is generally within weeks to months of supplementation. The effect sizes vary, but significant reductions in lipid parameters are noted across multiple studies.

How it works

Bergamot's polyphenols may act through antioxidant and anti-inflammatory pathways, influencing lipid metabolism. It interacts with the cardiovascular system by affecting lipid profiles and potentially with muscle physiology by improving strength and function. Specific molecular targets are not well-defined but likely involve pathways related to cholesterol synthesis and metabolism. The bioavailability of bergamot polyphenols is not extensively studied, but they are generally considered to be well-absorbed. These mechanisms contribute to the observed improvements in lipid parameters and potential benefits for cardiovascular health.

Side effects

Bergamot is generally considered safe, though comprehensive safety data are limited. Common side effects are not well-documented, but gastrointestinal upset is possible. Rarely reported side effects include allergic reactions. Potential interactions with statins have been noted, though some studies suggest synergistic effects. There are no specifically identified contraindications, but caution is advised for individuals with allergies to citrus fruits. Pregnant or breastfeeding women should consult healthcare providers before use. Due to limited comprehensive safety data, it is important to monitor for any adverse reactions and discontinue use if they occur.

Dosage

Doses used in studies often range from 500 to 1000 mg per day, though optimal dosing needs further research. Typically, dosages between 500 to 1000 mg per day are used. The maximum safe dose is not clearly defined, but doses above 1000 mg per day are less commonly studied. No specific timing recommendations are available. Bergamot is often used in capsule or extract form. Bioavailability may be influenced by the presence of other nutrients or compounds. No specific required cofactors have been identified. It is important to adhere to recommended dosages and consult with a healthcare provider for personalized advice.

FAQs

Is Bergamot safe to use?

Bergamot is generally considered safe but should be used under healthcare supervision, especially if combined with other medications. Comprehensive safety data are limited, so caution is advised.

When should I take Bergamot?

No specific timing is recommended, but consistency is key. It is often taken with meals to potentially improve absorption, but this is not definitively established.

How long does it take to see results from Bergamot supplementation?

Improvements in lipid profiles are expected within weeks to months. Individual results may vary, and consistent use is important for observing potential benefits.

Can Bergamot replace medical treatment?

Bergamot is not a replacement for medical treatment but may be used as a complementary approach. It is important to continue prescribed medications and consult with a healthcare provider.

Are there any side effects?

While considered safe, comprehensive safety data are limited. Gastrointestinal upset and allergic reactions are possible. Monitor for any adverse reactions and discontinue use if they occur.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/31670973/ – This study is a systematic review of bergamot's effect on lipid profiles. It found significant reductions in total cholesterol, LDL cholesterol, and triglycerides, with increases in HDL cholesterol. However, the authors noted that the quality of the included studies was variable, suggesting a need for more rigorous research.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11545342/ – This systematic review examined bergamot's impact on osteosarcopenic obesity. The review noted improvements in muscle strength and function, though the evidence was less robust compared to the lipid profile benefits. The findings suggest potential benefits beyond cardiovascular health, warranting further investigation.
https://www.tandfonline.com/doi/full/10.1080/10408398.2019.1677554 – This meta-analysis demonstrated significant decreases in total cholesterol, LDL cholesterol, and triglycerides, along with an increase in HDL cholesterol. The results support bergamot's efficacy in lipid management, reinforcing its potential as a nutraceutical for cardiovascular health. The study provides quantitative evidence of the effects of bergamot on lipid parameters.
https://onlinelibrary.wiley.com/doi/10.1002/ptr.7647 – This research article likely discusses the properties and potential benefits of bergamot. Further review of the full text would be needed to provide a more detailed summary of its key findings and methodology. The article could provide additional insights into the mechanisms of action or clinical applications of bergamot.
https://www.mdpi.com/2304-8158/13/23/3883 – This study likely investigates the effects of bergamot on various health parameters. A detailed review of the full text is necessary to summarize the specific findings and methodologies used. The research could offer valuable information regarding the efficacy and safety of bergamot supplementation in different contexts.