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Citrus Bioflavonoid Acerola Complex Blend

Also known as: Citrus flavonoids, Bioflavonoids, Hesperidin, Naringenin, Eriocitrin, Citrus Bioflavonoids

Overview

Citrus bioflavonoids are polyphenolic compounds derived from citrus fruits like oranges, lemons, and grapefruits. These compounds, including hesperidin, naringenin, and eriocitrin, are recognized for their antioxidant properties and potential health benefits. They are commonly used to support cardiovascular health, manage oxidative stress, and potentially aid in glycemic control. Citrus bioflavonoids work by scavenging free radicals and influencing biological pathways related to endothelial function and glucose metabolism. They are available in various forms, including dietary sources and supplements, and are often included in formulations aimed at enhancing antioxidant capacity and overall well-being. Research suggests that these compounds can improve flow-mediated vasodilation and reduce oxidative stress in specific populations, such as individuals with type 2 diabetes. The quality of evidence supporting their benefits is generally good, with several systematic reviews and meta-analyses available.

Benefits

Citrus bioflavonoids offer several evidence-based benefits, particularly in improving endothelial function and reducing oxidative stress. A systematic review and dose-response meta-analysis demonstrated that citrus flavonoid supplementation significantly improved flow-mediated vasodilation (FMD) by 2.75% (95% CI: 1.29, 4.20; p < 0.001), with each 200 mg/day increment increasing FMD by 1.09%. Furthermore, citrus bioflavonoids may reduce oxidative stress levels in patients with type 2 diabetes mellitus and positively impact markers of diabetes, such as reducing non-enzymatic protein glycation. While studies also suggest enhanced total antioxidant capacity and glutathione S-transferase activity, these findings are more general. The benefits are particularly notable for diabetic patients, where citrus bioflavonoids may serve as a complementary therapy to improve glycemic control.

How it works

Citrus bioflavonoids primarily function through their antioxidant properties, which help reduce oxidative stress and inflammation. They may also inhibit dipeptidyl peptidase-4 (DPP-4), an enzyme involved in glucose metabolism. These compounds improve endothelial function by enhancing nitric oxide production, which is crucial for vasodilation. By interacting with the cardiovascular system, they improve endothelial function, and by influencing glucose metabolism, they interact with the metabolic system. Absorption and bioavailability can vary depending on the specific compound and formulation, but they are generally well-absorbed when consumed in dietary forms or supplements.

Side effects

Citrus bioflavonoids are generally considered safe when consumed in typical dietary amounts or as supplements. Common side effects specifically attributed to citrus bioflavonoids are not well-documented, but they are generally well-tolerated. Uncommon and rare side effects have not been widely reported in the literature. Limited evidence exists regarding significant drug interactions, but caution is advised, especially for individuals with chronic conditions or those taking medications. No specific contraindications are widely recognized, but individuals with allergies to citrus should avoid these supplements. Pregnant or breastfeeding women and individuals with underlying health conditions should consult their healthcare provider before use. Overall, citrus bioflavonoids have a favorable safety profile, but awareness and caution are always recommended.

Dosage

The minimum effective dose for improving endothelial function and reducing oxidative stress is generally in the range of 200-500 mg/day of citrus flavonoids. For endothelial function, each 200 mg/day increment in citrus flavonoid supplementation has been associated with a significant increase in flow-mediated vasodilation. For antioxidant and anti-diabetic effects, doses ranging from 200 mg to 560 mg/day have been studied. There is no established maximum safe dose, but doses up to 560 mg/day have been used in studies without significant adverse effects. Consistent daily intake is likely beneficial, and citrus bioflavonoids can be consumed in various forms, including capsules, tablets, or as part of a dietary supplement blend. Vitamin C may enhance the absorption and effectiveness of citrus bioflavonoids.

FAQs

How do I choose a citrus bioflavonoid supplement?

Look for products that specify the content of active citrus bioflavonoids (e.g., hesperidin, naringenin) and ensure they are from reputable manufacturers.

Are citrus bioflavonoids safe for everyone?

Generally safe, but individuals with specific health conditions or allergies should consult their healthcare provider before use.

What benefits can I expect from taking citrus bioflavonoids?

Improved endothelial function, reduced oxidative stress, and potential benefits in glycemic control are the most commonly reported benefits.

When is the best time to take citrus bioflavonoids?

Consistent daily intake is recommended, but there is no specific timing that has been shown to be more effective.

Can citrus bioflavonoids replace medical treatments?

No, citrus bioflavonoids should not be used as a replacement for medical treatment but rather as a complementary therapy.

Research Sources

  • https://pubmed.ncbi.nlm.nih.gov/37939436/ – This systematic review focuses on the effects of citrus bioflavonoids on patients with type 2 diabetes mellitus. The key finding is that citrus bioflavonoids may reduce oxidative stress and improve glycemic control in this population. The review highlights the need for more studies to fully understand the mechanisms and effects, but it is a high-quality synthesis of data from multiple studies.
  • https://pubmed.ncbi.nlm.nih.gov/38561995/ – This systematic review and dose-response meta-analysis examined the impact of citrus flavonoid supplementation on endothelial function. Analyzing data from 596 participants across eight RCTs, the study found that citrus flavonoid supplementation significantly improved flow-mediated vasodilation (FMD), with a linear dose-response relationship. The authors note the need for longer intervention durations and studies in different populations, but the meta-analysis provides robust statistical evidence.
  • https://jscholaronline.org/full-text/JFN/9_101/Oral-Supplementation-of-Hydrolyzed.php – This study investigates the effects of oral supplementation of hydrolyzed potato protein and citrus bioflavonoids on exercise-induced muscle damage. The findings suggest that this combination may reduce muscle damage and inflammation following exercise. The study provides insights into the potential benefits of citrus bioflavonoids in the context of physical activity and recovery.
  • https://pubmed.ncbi.nlm.nih.gov/35897920/ – This analytical study assessed the citrus bioflavonoid content in 10 commercially available supplements. The key finding was significant variability in the content of citrus bioflavonoids among supplements, with hesperidin being the major component in most. While limited to an analysis of supplement content rather than clinical effects, it provides valuable information on the variability in supplement content.
  • https://bio-design.com/products/ascorbate-c-complex-120-vegetable-capsules – This is a product page for a supplement containing ascorbate-c complex. It highlights the potential benefits of combining vitamin C with bioflavonoids for enhanced antioxidant and immune support. While not a primary research article, it illustrates a common formulation strategy that leverages the synergistic effects of these compounds.

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