Citrus Natsudaidai Hayata Extract
Also known as: Natsudaidai, *Citrus natsudaidai*, Citrus natsudaidai Hayata, *Citrus natsudaidai* Hayata
Overview
Citrus natsudaidai, or Natsudaidai, is a citrus fruit endemic to Japan, lauded for its potential health benefits and rich array of bioactive compounds, particularly flavonoids such as hesperidin, naringin, and auraptene. Traditionally, it has been utilized for its antioxidant and anti-inflammatory properties, as well as its possible neuroprotective effects on the brain. Emerging research indicates a particular interest in its capacity to increase brain-derived neurotrophic factor (BDNF), which is crucial for neural health. Most of the investigations into its benefits are derived from in vitro and animal studies; hence, more clinical trials are needed to corroborate these findings in humans. The overall quality of available evidence remains limited due to the scarcity of human studies validating its purported health benefits.
Benefits
Citrus natsudaidai may enhance levels of BDNF, a neurotrophic factor involved in promoting neuronal survival and growth, which could have implications for conditions such as depression and Alzheimer's disease. Evidence from in vitro studies indicates a significant effect on BDNF production, although further research involving human participants is required to substantiate these claims. Besides its neuroprotective potentials, the flavonoids in Citrus natsudaidai exhibit notable antioxidant and anti-inflammatory effects that could contribute to overall health. Populations particularly at risk for neurodegenerative diseases may find potential benefits from its consumption, yet definitive clinical significance remains to be validated through well-designed human trials.
How it works
Citrus natsudaidai’s beneficial effects may stem from its ability to influence BDNF production through activation of the CREB (cAMP response element-binding protein) and ERK (extracellular signal-regulated kinase) signaling pathways. These pathways play crucial roles in neuronal survival and synaptic plasticity, affecting how neurons communicate and respond to stimuli. The extract's flavonoid components, such as auraptene, are believed to be particularly active in these biological processes, promoting neuroprotection and enhancing cognitive functions.
Side effects
Overall, Citrus natsudaidai is generally regarded as safe, with no widely documented common adverse effects. However, due to the lack of extensive human studies, uncommon or rare side effects remain largely unreported. Caution is advised for special populations, especially during pregnancy or breastfeeding, as comprehensive safety data is lacking. Potential drug interactions may also exist for individuals taking medications affecting the central nervous system or metabolism. Therefore, elderly individuals or those with chronic health data are advised to consult healthcare providers before starting this supplement.
Dosage
Currently, there is no established minimum effective dose for Citrus natsudaidai, nor are optimal dosing ranges defined due to the limited clinical data. In vitro studies have utilized concentrations ranging between 25-100 μg/mL, but translating these findings to human dosages remains speculative. Factors influencing bioavailability have not been thoroughly researched, and therefore, recommendations on the timing of administration are also not established. Until further research clarifies dosage parameters and safety thresholds, users are encouraged to approach this supplement cautiously.
FAQs
Is Citrus natsudaidai safe to use?
While generally considered safe, comprehensive safety data are lacking. Consulting with a healthcare provider is recommended, especially for specific health concerns.
What benefits can I expect from using Citrus natsudaidai?
Potential benefits include neuroprotection and antioxidant effects, but more human studies are needed for conclusive results.
What dosage should I take?
Optimal dosages are not established. In vitro studies used doses of 25-100 μg/mL; human applications are unclear.
Can Citrus natsudaidai help with neurodegenerative diseases?
It may increase BDNF levels, which could be beneficial for neurodegenerative conditions, but evidence is currently limited.
Are there any known side effects?
Common side effects are not well-documented and may vary; consult healthcare professionals for guidance.
Research Sources
- https://www.jstage.jst.go.jp/article/jos/72/2/72_ess22324/_pdf – This study demonstrates that extracts from *Citrus natsudaidai* significantly increase BDNF levels in cells, offering insight into its neuroprotective effects; however, more human trials are needed to confirm these findings.
- https://www.woodj.org/archive/view_article?pid=wood-50-4-272 – Research on essential oils from *Citrus natsudaidai* evaluates its antioxidant activities, suggesting potential health benefits but emphasizing the need for further studies on its neuroprotective properties.
- https://pubmed.ncbi.nlm.nih.gov/32182635/ – This publication highlights the need for more systematic research into *Citrus natsudaidai*, pointing out gaps in human studies that would validate its proposed health benefits.
- https://pubs.acs.org/doi/abs/10.1021/jf052409j – The study illustrates the antioxidant properties of various citrus extracts, including *Citrus natsudaidai*, indicating potential applications in health supplementation.
- https://www.researchgate.net/publication/367010927_Increase_in_Effect_of_Citrus_natsudaidai_on_Brain-Derived_Neurotrophic_Factor – This research explores the effects of *Citrus natsudaidai* on increasing BDNF levels, highlighting the extract's potential for neuroprotection, yet reinforcing the importance of human clinical studies.
