Clary Sage Glycerite Liquid Extract
Also known as: Clary Sage, Clear Eye, Muscatel Sage, Clary Sage Glycerite Liquid Extract, Salvia sclarea
Overview
Clary Sage glycerite liquid extract is a preparation derived from the plant *Salvia sclarea*, commonly known as Clary Sage. This extract typically involves the active compounds being extracted into a glycerin base, making it suitable for both oral and topical application. Traditionally, Clary Sage has been valued for its distinct aromatic and therapeutic properties, particularly in promoting relaxation, modulating mood, and supporting hormonal balance. In the context of supplements, it is primarily utilized for its potential benefits in psychological well-being, including alleviating symptoms of anxiety and depression, and offering relief for menopausal symptoms. While research on Clary Sage essential oil and other *Salvia* extracts is moderate, high-quality clinical trials specifically on the glycerite liquid extract form are currently limited. Existing evidence largely stems from studies on Clary Sage essential oil inhalation and broader research on related *Salvia* species, which provide insights into its potential mechanisms and effects.
Benefits
Clary Sage glycerite liquid extract, primarily through its active compounds, offers several potential benefits. For psychological effects, a 2025 randomized controlled trial (RCT) demonstrated that inhalation of clary sage oil significantly reduced anxiety and heart rate in patients with diabetic foot ulcers, showing statistical significance (p < 0.05) and meaningful effect sizes compared to controls. The same study also reported reductions in depression scores, particularly in individuals with moderate to severe depression. While not specific to the glycerite form, sage species have shown promise in relieving menopausal symptoms; a 2023 meta-analysis of four RCTs indicated that sage supplements (100-280 mg/day) could reduce hot flash frequency due to their estrogen-like effects. Furthermore, related *Salvia* species contain bioactive compounds like rosmarinic acid and ursolic acid, which possess anti-inflammatory properties and may contribute to cognitive benefits. The aromatherapeutic benefits of Clary Sage, such as promoting relaxation, mental clarity, and emotional balance, are widely reported, though these are mainly supported by qualitative and smaller-scale studies.
How it works
The primary active constituents of Clary Sage, including linalyl acetate and linalool, are believed to modulate the autonomic nervous system. They achieve this by reducing sympathetic activity and promoting parasympathetic dominance, which leads to physiological effects such as lowered anxiety and reduced heart rate. Additionally, certain phytochemicals found in sage species exhibit estrogen-like properties, potentially binding to estrogen receptors in the brain. This interaction may influence neurotransmitter systems involved in mood regulation and thermoregulation, contributing to benefits like menopausal symptom relief. Anti-inflammatory effects observed in related *Salvia* species are mediated through the inhibition of key inflammatory mediators such as COX-2, iNOS, and pro-inflammatory cytokines like TNF-α and IL-1β. The bioavailability of compounds from glycerite extracts depends on the specific preparation but generally allows for effective absorption, particularly via the oral mucosa.
Side effects
Clary sage extracts and oils are generally considered safe when used appropriately. Side effects are rare but may include mild skin irritation or allergic reactions, particularly when applied topically. There have been no significant drug interactions or contraindications reported in high-quality clinical trials specifically for Clary Sage. However, due to its potential hormonal effects, pregnant or breastfeeding women should exercise caution and consult a healthcare professional before use. Individuals with hormone-sensitive conditions should also be cautious due to the potential estrogenic effects. While generally well-tolerated, it is always advisable to start with a low dose to assess individual tolerance. There is no evidence of severe adverse effects or toxicity when used within recommended guidelines.
Dosage
For Clary Sage glycerite liquid extract, standardized dosing is not yet well-established due to limited specific clinical trials on this form. Clinical studies on clary sage oil inhalation have used short-term exposure, with typical aromatherapy doses ranging from a few drops inhaled or diffused. For oral glycerite extracts, dosage recommendations are often extrapolated from studies on other sage preparations. For instance, studies on sage supplements for menopausal symptoms suggest doses of 100-280 mg/day of standardized extract. Optimal dosing for specific conditions requires further randomized controlled trials. Therefore, it is crucial to follow product-specific recommendations provided by reputable manufacturers. The timing of dosage can be flexible but is often aligned with the occurrence of symptoms, such as during episodes of anxiety or when experiencing menopausal hot flashes. Upper limits and safety thresholds for the glycerite form are not definitively established, emphasizing the importance of adhering to product guidelines.
FAQs
Is clary sage glycerite extract effective for anxiety?
Evidence from clary sage oil inhalation studies suggests benefits for anxiety reduction, but direct evidence for oral glycerite extract is currently limited. More research is needed to confirm its efficacy in this form.
Can it replace hormone therapy for menopause?
While sage species may help reduce hot flash frequency, Clary Sage glycerite extract is not a substitute for prescribed hormone therapy. Consult a healthcare provider for menopausal symptom management.
Are there risks of hormonal imbalance?
Due to potential estrogenic effects, caution is advised for individuals with hormone-sensitive conditions. Pregnant or breastfeeding women should consult a doctor before use.
How soon do benefits appear?
Aromatherapy effects from clary sage oil can be immediate. For oral supplementation with glycerite extract, benefits may take several weeks to become noticeable, similar to other herbal supplements.
Research Sources
- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1523441/full – This randomized controlled trial (n=72) investigated clary sage oil inhalation in diabetic foot patients, demonstrating significant reductions in anxiety and depression scores, heart rate, and mean arterial pressure. The study highlights the anxiolytic and mood-modulating potential of clary sage, though it focuses on inhalation rather than glycerite extract and a specific patient population.
- https://pubmed.ncbi.nlm.nih.gov/37484695/ – This 2023 meta-analysis of four randomized controlled trials (sample sizes ≥30) on sage supplements for menopausal symptoms found a significant reduction in hot flash frequency, but not severity, with doses of 100-280 mg/day over 4-12 weeks. This supports the estrogen-like effects of sage species, though it is not specific to Clary Sage glycerite.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5318325/ – This review discusses bioactive compounds found in *Salvia* species, such as rosmarinic acid and tanshinones, and their demonstrated anti-inflammatory and neuroprotective effects in in vitro and animal models. It suggests potential mechanisms for cognitive and mood benefits, but notes that human randomized controlled trials specifically for Clary Sage glycerite are lacking.
Supplements Containing Clary Sage Glycerite Liquid Extract
Clary Sage (Salvia sclarea)
TerraVita
Clary Sage (Salvia sclarea) Mint Flavor
TerraVita
Clary Sage (Salvia sclarea) Strawberry Flavor
TerraVita
Clary Sage (Salvia sclarea) Chocolate Flavor
TerraVita
Clary Sage (Salvia sclarea) Vanilla Flavor
TerraVita