Clerodendrum Phlomidis Extract
Also known as: Clerodendrum phlomidis Linn. f., Clerodendrum phlomidis
Overview
Clerodendrum phlomidis is a plant utilized in traditional medicine, particularly within Ayurvedic and Siddha systems, for its purported medicinal properties. Native to regions where these practices are prevalent, it has been traditionally employed to address various ailments, including inflammation, diabetes, and digestive disorders. The plant is characterized by the presence of compounds such as ursolic acid and lupeol, which have been identified as pharmacologically active components. While research has explored its pharmacological activities, comprehensive clinical trials remain limited, with most studies being preclinical or based on traditional use. The quality of available evidence is therefore considered preliminary, necessitating further rigorous investigation to validate its efficacy and safety.
Benefits
Studies suggest potential anti-obesity, antioxidant, and anti-inflammatory effects. For example, Clerodendrum phlomidis leaf extract has been shown to reduce body weight and fat accumulation in animal models. It may also have analgesic, antidiarrheal, antiplasmodial, hypoglycemic, and immunomodulatory effects based on traditional use and some preclinical studies. Potential benefits for individuals with metabolic syndrome or obesity have been suggested, though more research is needed. Specific effect sizes are not well-documented in human studies, and the time course of benefits is not well-studied in humans. The current evidence is primarily preclinical, warranting cautious interpretation and further clinical validation.
How it works
Clerodendrum phlomidis extract may influence metabolic pathways related to obesity and inflammation, potentially through compounds like ursolic acid and lupeol. It may interact with the endocrine system, such as insulin regulation, and the immune system, exhibiting anti-inflammatory effects. However, specific molecular targets have not been definitively identified in human studies. The bioavailability of Clerodendrum phlomidis extract is reported to be low due to poor solubility and high metabolism, which may affect its efficacy. Further research is needed to fully elucidate its mechanisms of action and optimize its bioavailability.
Side effects
Overall safety data for Clerodendrum phlomidis are lacking, though it is generally considered safe in traditional use. Common, uncommon, and rare side effects are not well-documented in available literature. Potential interactions with diabetes medications exist due to its hypoglycemic effects. Contraindications are not well-established. Caution is advised in pregnant or breastfeeding women due to a lack of data. Comprehensive safety assessments are needed to fully understand the potential adverse effects and interactions associated with Clerodendrum phlomidis extract. Individuals should consult healthcare providers before use, especially if they have pre-existing conditions or are taking medications.
Dosage
A minimum effective dose has not been established in human studies, and optimal dosage ranges are not defined. The maximum safe dose has not been determined. Timing considerations are not specified. It is typically used as an extract. Bioavailability issues may affect efficacy. Required cofactors have not been identified. Due to the lack of comprehensive data, it is crucial to consult with a healthcare professional before using Clerodendrum phlomidis extract to determine appropriate and safe dosages.
FAQs
What are the practical usage concerns?
Users should consult healthcare providers due to potential interactions and a lack of comprehensive safety data. It is essential to seek professional guidance before incorporating this extract into a health regimen.
Is Clerodendrum phlomidis extract safe?
While traditionally used, modern safety assessments are needed. Current data is insufficient to definitively establish its safety profile, necessitating further research and cautious use.
What are the expected results?
Potential benefits for metabolic health have been suggested, but more research is required. The current evidence is preliminary, and further studies are needed to validate these potential benefits.
Can Clerodendrum phlomidis extract replace medical treatment?
It is not a substitute for medical treatment without sufficient evidence. Individuals should not rely on this extract as a replacement for prescribed medical interventions.
Research Sources
- https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/1425187419.pdf – This study examined the effects of Clerodendrum phlomidis leaf extract in rats, finding a significant reduction in body weight and fat accumulation. The results suggest potential anti-obesity effects, indicating a possible role in managing weight-related issues. However, these findings are based on animal models and require further validation in human clinical trials.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9288331/ – This study explored the incorporation of Clerodendrum phlomidis extract into electrospun nanofibers to enhance its bioavailability and efficacy. The nanofibers were assessed for antibacterial and anticancer activities, showing promising results. This approach aims to improve the delivery and effectiveness of the extract, potentially expanding its therapeutic applications.
- https://pubmed.ncbi.nlm.nih.gov/20550872/ – This review highlighted the plant's traditional uses and potential pharmacological activities, including anti-inflammatory and hypoglycemic effects. The review emphasizes the need for more clinical research to validate these effects and establish the plant's therapeutic potential. While traditional uses are noted, rigorous scientific investigation is required to confirm its efficacy and safety.
- https://www.electricveg.com/lamiaceae.html – This website provides general information about plants in the Lamiaceae family, which includes Clerodendrum phlomidis. It may offer insights into the plant's botanical characteristics and traditional uses. However, the information should be cross-referenced with peer-reviewed scientific literature for accuracy and reliability.
- https://pub.iapchem.org/ojs/index.php/admet/article/view/2442 – This resource likely contains information related to the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) properties of compounds, potentially including those found in Clerodendrum phlomidis. Understanding these properties is crucial for assessing the safety and efficacy of the extract. Further analysis of the specific content is needed to determine its relevance to Clerodendrum phlomidis.