Cnidium Seed Extract
Also known as: Cnidium seed, She Chuang Zi, Cnidium monnieri
Overview
Cnidium monnieri, commonly known as Cnidium seed or She Chuang Zi, is a flowering plant traditionally used in Chinese medicine, primarily for its seeds that possess various medicinal characteristics. This herbal supplement is known for its bioactive compounds, particularly osthole and imperatorin, which have demonstrated pharmacological effects. Its applications include the treatment of sexual dysfunction, skin ailments, and hypertension. Although research interest is growing, the robustness and quantity of clinical evidence are variable, necessitating further studies to confirm its efficacy and safety in modern usage.
Benefits
Cnidium monnieri has shown several potential health benefits backed by evidence, particularly its vasorelaxant effects which may aid in lowering blood pressure. These effects have been supported by animal studies, indicating promising implications for individuals with hypertension. Additionally, some studies suggest its potential anticancer properties, specifically against hepatocellular carcinoma, although this remains to be validated through human clinical trials. The strength of evidence varies, with significant effects noted in preclinical models but lacking rigorous human studies.
How it works
The vasorelaxant effect of Cnidium monnieri is primarily mediated through the inhibition of calcium channels and modulation of the renin-angiotensin system. Osthole and imperatorin, the main active compounds, interact with vascular smooth muscle, fostering relaxation and potentially reducing blood pressure. However, the mechanisms of action in humans remain largely unstudied, indicating a need for more comprehensive research.
Side effects
The safety profile of Cnidium monnieri is generally considered favorable based on traditional use; however, modern safety data is limited. Commonly unreported side effects may include allergic reactions or gastrointestinal discomfort, though comprehensive data is lacking. There are concerns regarding potential drug interactions, especially with antihypertensive medications due to its vasodilatory properties. It's advised to avoid use during pregnancy or breastfeeding due to insufficient safety data, and caution is warranted in individuals with existing cardiovascular conditions.
Dosage
There is no established minimum effective dose for humans, as Cnidium monnieri is often used without standardized dosages in traditional medicine. Recommendations for usage typically vary, with no clear maximum safe dose identified. As such, users are advised to consult healthcare providers, particularly concerning timing and administration. Forms of consumption often include extracts or combinations with other herbal remedies, but specific absorption data are currently unknown.
FAQs
Is Cnidium monnieri safe to use?
While traditionally considered safe, modern safety data is limited; consult a healthcare provider before use, particularly if on medications.
How does Cnidium monnieri affect blood pressure?
It may help lower blood pressure through vasorelaxation, but more human studies are needed to confirm its efficacy.
What should I know about dosing?
There are no standardized dosages; consult a healthcare provider for guidance based on individual health needs.
Can I use Cnidium monnieri if I'm pregnant?
No, it is advised to avoid use during pregnancy due to insufficient safety information.
What are the potential side effects?
Possible side effects include allergic reactions and gastrointestinal discomfort, but data on adverse effects is limited.
Research Sources
- https://www.mdpi.com/1422-0067/25/8/4223 – This study observed the vasorelaxant effects and blood pressure-lowering properties of Cnidium monnieri in hypertensive rats, providing mechanistic insights but lacking human data.
- https://osf.io/mepkc/?action=download – This theoretical model suggested anticancer effects of bioactive compounds in Cnidium monnieri against hepatocellular carcinoma, though it lacks experimental validation.
- https://www.mdpi.com/1422-0067/23/10/5400 – The review summarizes the phytochemical composition and traditional uses of Cnidium monnieri, providing a comprehensive overview but not advancing new empirical research.
- https://www.tandfonline.com/doi/full/10.1080/13880209.2022.2110267 – This review discusses the pharmacological properties of Cnidium monnieri, underscoring the need for more clinical studies to validate traditional uses.
- https://www.worldscientific.com/doi/10.1142/S0192415X15500500 – This source highlights various medicinal uses of Cnidium monnieri, acknowledging its historical significance while noting the limited modern scientific validation.