Coleus Forskohlii Whole Plant Extract
Also known as: Plectranthus barbatus, Coleus barbatus, Makandi, Patharchur, Coleus forskohlii
Overview
*Coleus forskohlii* is an aromatic perennial plant indigenous to tropical and subtropical regions, particularly found in the Indian subcontinent. Traditionally utilized in Ayurvedic medicine, it is distinguished by its main bioactive compound, forskolin, which is being investigated for various therapeutic applications. Research indicates its usage may extend to cardiovascular support, gastrointestinal health, respiratory conditions, urinary issues, and central nervous system disorders. Its pharmacological properties, primarily attributed to forskolin, could provide benefits in managing conditions such as glaucoma, asthma, and obesity. However, existing research is primarily in the preliminary stage, with the majority arising from animal studies or small-scale human trials, necessitating further rigorous clinical investigations to solidify its efficacy and applications.
Benefits
The primary evidence-based benefits of *Coleus forskohlii* include: - **Glaucoma**: Forskolin eye drops have been shown to potentially reduce intraocular pressure, though results for oral forms are inconsistent. - **Asthma**: Limited studies indicate a possible reduction in asthma attacks, particularly in children. - **Obesity**: Some studies reported fat loss in overweight/obese men, although findings are mixed overall. Secondary effects include potential anticancer, antifibrotic, thyroid-stimulating, and anti-inflammatory impacts, mainly supported by in vitro and animal studies. Importantly, the most notable benefits seem to accrue to overweight men regarding testosterone levels and body composition, though evidence shows effect sizes that are generally small to moderate.
How it works
Forskolin acts primarily by activating adenylyl cyclase, an enzyme that increases levels of cyclic adenosine monophosphate (cAMP) within cells. Elevated cAMP modulates several cellular processes concerning metabolism, hormone secretions, neurotransmission, and muscle contractions. The interaction involves various body systems that rely on cAMP signaling. Specific molecular targets include different isoforms of adenylyl cyclase, but the exact pathways affected by forskolin's action and its systemic absorption need further exploration.
Side effects
The safety profile of *Coleus forskohlii* is generally favorable when used at recommended doses, although gastrointestinal upset, particularly diarrhea, is the most commonly reported side effect occurring in over 5% of users. Documentation of less frequent side effects (<5%) is sparse. Potential interactions with other medications, notably antihypertensives and blood thinners, warrant caution. Contraindications include hypotension, bleeding disorders, and stomach ulcers. Given the limited safety data, special populations—particularly pregnant women and children—should exercise caution when considering its use. Consulting healthcare professionals before incorporating this supplement is advisable, especially for those with preexisting conditions.
Dosage
The optimal dosage for *Coleus forskohlii* extract, standardized for 10% forskolin, generally ranges around 250 mg taken twice a day. However, the minimum effective dose remains unestablished, and maximum safe dosages are also undefined. There are no specific timing recommendations, and form-specific uses include oral capsules and topical applications (eye drops for glaucoma). Insights into absorption factors are quite limited, and no required cofactors are documented, emphasizing the need for user awareness regarding age and health status when taking the supplement.
FAQs
What precautions should I take?
Monitor your blood pressure and gastrointestinal health, particularly if you have a history of hypotension or ulcers.
Is there a recommended timing for taking this supplement?
There are no specific timing recommendations; it can be taken at any time of the day.
How long will it take to see results?
Results can vary widely; some may notice effects within a few weeks, while others may take longer.
Can I use it while on medication?
Caution is advised as *Coleus forskohlii* may interact with blood thinners and antihypertensives.
Are the weight loss benefits exaggerated?
Yes, many claims are based on limited evidence; results are not guaranteed and can vary.
Research Sources
- https://academicjournals.org/journal/JMPR/article-full-text-pdf/DD448E315429.pdf – This study explores the various applications of *Coleus forskohlii*, particularly focusing on forskolin's diverse pharmacological activities, including its impact on weight management and metabolic processes.
- https://examine.com/supplements/coleus-forskohlii/ – Examine.com provides a comprehensive overview of *Coleus forskohlii*, detailing its uses, potential effects on health, and discussing the scientific evidence for these claims based on available research.
- https://www.researchgate.net/publication/260210752_Botanical_Description_of_Coleus_forskohlii_A_Review – This review presents a detailed botanical description of *Coleus forskohlii*, summarizing key phytochemical constituents and their potential roles in health and disease management.
- https://pubmed.ncbi.nlm.nih.gov/26593941/ – Research reported in this PubMed citation investigates various pharmacological properties of forskolin derived from *Coleus forskohlii*, focusing on its therapeutic effects across numerous conditions.
- https://www.researchgate.net/publication/268441079_Coleus_forskohlii_A_comprehensive_review_on_morphology_phytochemistry_and_pharmacological_aspects – This comprehensive review encapsulates morphological features, phytochemical details, and pharmacological aspects of *Coleus forskohlii*, highlighting its traditional uses and modern research findings.
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