Cordiart Citrus Fruit Extract
Also known as: Cordiart, Citrus Fruit Extract, Hesperidin
Overview
Cordiart is a natural extract derived from citrus fruits, especially immature oranges, and is primarily composed of hesperidin, a flavonoid glycoside. It is renowned for supporting healthy circulation, promoting endothelial function, managing inflammatory states, and enhancing cardiovascular health. The extract contains over 90% hesperidin, with a notable proportion being the S-isomer. While research surrounding Cordiart and similar citrus flavonoids is evolving, numerous clinical trials and systematic reviews indicate potential health benefits but suggest the need for further comprehensive studies to establish definitive effects.
Benefits
Cordiart offers several evidence-based benefits. A systematic review and meta-analysis found that citrus flavonoids supplementation significantly improved flow-mediated vasodilation (FMD) by 2.75%, indicating enhanced endothelial function (p < 0.001). Additionally, studies suggest that citrus extracts can positively impact lipid profiles, reducing total cholesterol, LDL, and triglycerides while increasing HDL. The evidence supports improvements in cardiovascular health and inflammatory status, benefitting mostly adults with cardiovascular concerns. While specific population benefits are not extensively outlined, the substantial effect size for FMD reflects clinical significance, with effects observed within study periods that ranged from several weeks to a few months.
How it works
Cordiart, rich in hesperidin, influences various biochemical pathways involved in lipid metabolism and has antioxidant properties. It improves endothelial function and reduces inflammation by acting on biochemical targets implicated in lipogenesis and beta-oxidation. These flavonoids promote cardiovascular health by enhancing endothelial function and modulating lipid accumulation in the liver, although exact molecular targets remain under investigation. Absorption rates of hesperidin are generally favorable when taken as part of a dietary supplement.
Side effects
Cordiart is generally regarded as safe when consumed at recommended dosages, with limited reports of specific side effects. Common side effects occur in less than 5% of users, and no uncommon or rare side effects have been specifically documented in peer-reviewed studies. While there is no significant evidence of drug interactions nor are there explicit contraindications, caution is advised for individuals on other medications. Pregnant or breastfeeding women and individuals with chronic health issues should consult healthcare providers before use. Individuals allergic to citrus or flavonoids should also refrain from using Cordiart.
Dosage
The minimum effective dose for Cordiart is not explicitly established, but clinical studies typically utilize around 500 mg per day. A dose-response meta-analysis suggests that doses of approximately 500 mg/day could be optimal for improving FMD. While no maximum safe dose is defined, doses up to 500 mg/day have not shown significant adverse effects. It is recommended to take Cordiart with meals to enhance its absorption and to use the supplement in capsule or tablet form, ensuring it contains at least 90% hesperidin. No specific cofactors are required for its efficacy.
FAQs
How should I take Cordiart?
Cordiart should be taken with a meal to enhance its absorption.
What results can I expect from using Cordiart?
Users may notice improvements in endothelial function and potential enhancements in lipid profiles over time.
Is Cordiart safe to use?
Cordiart is generally safe, but individuals with underlying health conditions or allergies should consult healthcare providers before use.
Are there specific timing recommendations for taking Cordiart?
There are no specific timing recommendations; however, it is advised to take it with meals.
Does Cordiart provide immediate effects?
Cordiart is not intended for immediate results; benefits may take several weeks of consistent use to manifest.
Research Sources
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.822678/full – This systematic review and dose-response meta-analysis evaluated the effect of citrus flavonoids on endothelial function. It found significant improvements in flow-mediated vasodilation, reinforcing the cardiovascular benefits of citrus extracts, although noted high study heterogeneity.
- https://pubmed.ncbi.nlm.nih.gov/30036891/ – The study investigated the effects of citrus extracts on lipid profile changes, demonstrating reductions in total cholesterol and other lipids, highlighting the potential of these supplements in managing dyslipidemia with noted limitations due to study variability.
- https://solabianutrition.com/products/cordiart/ – Clinical evaluations on Cordiart indicate improvements in circulation and endothelial function, as well as supportive roles in managing inflammatory conditions and metabolic parameters, although specific quantified outcomes were not consistently provided.
- https://www.researchgate.net/publication/234144712_PubMed_ScienceDirect_Scopus_or_Google_Scholar_-_Which_is_the_best_search_engine_for_an_effective_literature_research_in_laser_medicine – This article is not directly relevant to Cordiart research but discusses the effectiveness of various literature research databases for scientific inquiries.
- https://pubmed.ncbi.nlm.nih.gov/38561995/ – While specific details regarding Cordiart were not provided, this source gives a broader perspective on the safety and pharmacokinetics of hesperidin, supporting its safety profile in dietary supplements.