Cordiart Purified Flavonoid Glycoside
Also known as: Cordiart Purified Flavonoid Glycoside, Cordiart®, purified flavonoid glycoside from citrus, rutinoside extract, Hesperidin
Overview
Cordiart Purified Flavonoid Glycoside is a natural extract primarily composed of hesperidin, a flavonoid glycoside derived from immature *Citrus sinensis* (sweet orange). It contains over 90% bioflavonoids, with more than 60% as the S-isomer of hesperidin. This supplement is specifically designed to support cardiovascular health by improving endothelial function, reducing inflammation, and enhancing blood flow. It targets endothelial dysfunction, arterial flexibility, and inflammatory markers associated with cardiovascular disease (CVD). While a specialized product, it has a moderate level of research maturity, with evidence suggesting benefits for vascular health, including improvements in Flow Mediated Dilatation (FMD) and reductions in circulating adhesion molecules.
Benefits
Cordiart Purified Flavonoid Glycoside offers several evidence-based benefits for cardiovascular health. Its primary effect is a significant improvement in Flow Mediated Dilatation (FMD), a key marker of endothelial function, observed after 6 weeks of 500 mg daily supplementation. It also effectively reduces circulating adhesion molecules such as sICAM-1 and sVCAM-1, which are critical in vascular inflammation and plaque formation. A significant reduction in blood pressure has also been observed in clinical trials. Secondary benefits include a decrease in lipid accumulation in pre-adipocytes, potentially contributing to reduced vascular inflammation. These benefits are particularly relevant for adults with endothelial dysfunction or those at risk of cardiovascular disease. The clinical trial demonstrated statistically significant improvements (p < 0.05) in FMD and inflammatory markers, indicating a robust effect.
How it works
Cordiart Purified Flavonoid Glycoside primarily exerts its effects by activating endothelial nitric oxide synthase (eNOS), which leads to increased production of nitric oxide (NO). NO is a potent vasodilator, promoting relaxation of blood vessels and improving blood flow. The supplement also reduces vascular inflammation by lowering the levels of adhesion molecules like sICAM-1 and sVCAM-1, which are involved in the adhesion of immune cells to the vascular lining. Furthermore, it enhances arterial flexibility and reduces lipid accumulation within vascular cells. The flavonoids in Cordiart also modulate inflammatory pathways and oxidative stress within the vascular endothelium, contributing to overall cardiovascular health. While hesperidin's bioavailability can be a challenge, the purified form in Cordiart aims to optimize absorption.
Side effects
Flavonoid glycosides, including hesperidin found in Cordiart Purified Flavonoid Glycoside, are generally considered safe with a favorable safety profile. Clinical trials conducted with Cordiart have not reported any significant adverse effects. Common side effects, if they occur, are rare and typically mild. There are no major drug interactions or contraindications documented in the reviewed literature for Cordiart. However, specific data for special populations such as pregnant women, breastfeeding mothers, or children are lacking, and therefore, these groups should exercise caution and consult a healthcare professional before use. As with any supplement, individuals with pre-existing medical conditions or those taking prescription medications should seek medical advice to ensure safety and avoid potential interactions.
Dosage
The minimum effective dose for Cordiart Purified Flavonoid Glycoside, as established in clinical trials, is 500 mg daily. This dosage is also considered the optimal and clinically tested amount. The maximum safe dose has not been clearly established, but no adverse events were reported at the 500 mg daily intake. For timing, daily supplementation is recommended, with no specific timing requirements reported to influence efficacy. Cordiart is available in various forms, including capsules, powder blends, and soft gels. While absorption might be enhanced by co-administration with certain nutrients like vitamin C, specific cofactors are not detailed as essential for its efficacy. Adhering to the recommended 500 mg daily dose is crucial for achieving the observed cardiovascular benefits.
FAQs
Is Cordiart® effective for blood pressure?
Yes, a 6-week randomized controlled trial demonstrated significant blood pressure reduction with daily Cordiart® supplementation.
How quickly do benefits appear?
Effects on endothelial function and inflammation, key cardiovascular benefits, were observed within 6 weeks of consistent supplementation.
Is it safe long-term?
Long-term safety data for Cordiart® are limited, but short-term use (up to 6 weeks) appears safe with no significant adverse effects reported.
Can it be combined with other supplements?
Yes, Cordiart® is compatible with other supplements like L-arginine, vitamins K, D, and folic acid, enhancing its versatility.
Research Sources
- https://cordiart.com – This source provides general information about Cordiart, highlighting its natural origin from citrus and its role in supporting cardiovascular health. It emphasizes the product's focus on improving endothelial function and reducing inflammation.
- https://www.minervamedica.it/en/journals/international-angiology/article.php?cod=R34Y2018N02A0143 – This citation refers to a randomized placebo-controlled trial (n=68) on Cordiart. The study found that 500 mg daily for 6 weeks significantly improved endothelial function (FMD), reduced adhesion molecules (sICAM-1, sVCAM-1), and lowered blood pressure, demonstrating its cardiovascular benefits.
- https://solabianutrition.com/products/cordiart/ – This source, likely a product page, offers details on Cordiart's composition, emphasizing its high hesperidin content and its intended use for vascular health. It reiterates the benefits observed in clinical studies, such as improved blood flow and reduced inflammation.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7571023/ – This link points to a comprehensive review on flavonoids in cardiovascular disease. It explains the mechanisms by which flavonoids like hesperidin improve endothelial function through eNOS activation and NO production, reduce oxidative stress, and modulate inflammation, providing biological plausibility for Cordiart's effects.
- https://www.woundsource.com/blog/edema-and-micronized-purified-flavonoid-fraction-what-evidence-says – This source discusses a systematic review and meta-analysis on Micronized Purified Flavonoid Fraction (MPFF), which, while not Cordiart, is a similar flavonoid blend. The review of 7 RCTs (n=1692) showed MPFF significantly improved leg symptoms, reduced edema, and enhanced quality of life in chronic venous disease patients, supporting the broader vascular benefits of purified flavonoid fractions.
Supplements Containing Cordiart Purified Flavonoid Glycoside
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