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Coriolus

Also known as: Coriolus versicolor, Turkey tail, Trametes versicolor

Overview

Coriolus versicolor, commonly known as turkey tail, is an edible mushroom found worldwide. It is recognized for its potential health benefits and has been used in traditional medicine. This mushroom contains polysaccharide-K (PSK) and polysaccharopeptide (PSP), which are believed to have immunomodulatory effects. It is primarily used as a dietary supplement to support immune function and as an adjunctive therapy in cancer treatment. Research on Coriolus versicolor is considered to be at a moderate level, with several clinical trials and meta-analyses examining its effects, particularly in cancer patients. While some studies show promising results, more rigorous trials are needed to fully establish its efficacy and safety. The available evidence is generally of moderate quality.

Benefits

Coriolus versicolor has demonstrated potential benefits, particularly in cancer treatment. A meta-analysis indicated that products containing Coriolus versicolor and Ganoderma lucidum were associated with a lower mortality risk (HR: 0.82; 95% CI: 0.72, 0.94) and higher total efficacy in cancer treatment (RR: 1.30; 95% CI: 1.09, 1.55). These products also showed favorable effects on immune markers, such as CD3 and CD4 levels. The beneficial effects have been noted in cancer patients, enhancing immune function and potentially improving survival rates. The effect sizes suggest a moderate benefit in cancer treatment outcomes. The duration of these benefits is not well-defined and may vary based on individual response and treatment duration.

How it works

Coriolus versicolor is believed to modulate the immune system by enhancing the activity of natural killer cells and T-cells. It interacts primarily with the immune system, potentially influencing cytokine production and immune cell activity. The polysaccharides in Coriolus versicolor may interact with immune receptors to stimulate an immune response. While the bioavailability of its active components is not well-studied, oral administration is common. This interaction with the immune system is thought to be the primary mechanism through which Coriolus versicolor exerts its beneficial effects.

Side effects

Coriolus versicolor is generally considered safe when used appropriately. Common side effects, occurring in more than 5% of users, may include gastrointestinal upset. Uncommon side effects, affecting 1-5% of users, may involve allergic reactions, although these are rare. Severe allergic reactions or interactions with medications are rare, affecting less than 1% of users. There are potential interactions with immunosuppressive drugs or chemotherapy agents. It should be used cautiously in patients with autoimmune diseases or those taking immunosuppressive medications. Pregnant or breastfeeding women should consult healthcare providers before use. It is important to monitor for any adverse reactions and discontinue use if necessary.

Dosage

The minimum effective dose of Coriolus versicolor is not well-established, but it is typically used in doses ranging from 1 to 3 grams per day. Doses vary widely based on the specific product and intended use. The maximum safe dose is not clearly defined, but high doses (e.g., above 6 grams per day) are not commonly recommended. It can be taken with meals to reduce gastrointestinal side effects. Coriolus versicolor is available in capsule, powder, or extract forms. Bioavailability may be influenced by the form and preparation method. There are no specifically identified required cofactors. Consult a healthcare provider for personalized dosage recommendations.

FAQs

How can I ensure the quality of Coriolus versicolor supplements?

Ensure the product is from a reputable source to minimize contamination risks. Look for products that have been third-party tested for purity and potency.

Is Coriolus versicolor safe to use during cancer treatment?

While generally safe, it should be used under medical supervision, especially in cancer treatment. It is not a replacement for conventional cancer treatment.

How often should I take Coriolus versicolor?

It can be taken daily, but consult a healthcare provider for specific guidance. Follow the dosage recommendations on the product label or as advised by your healthcare provider.

What are the expected results from taking Coriolus versicolor?

It may enhance immune function and potentially improve cancer treatment outcomes. Individual results may vary, and it is not a guaranteed cure.

Can Coriolus versicolor replace conventional cancer treatment?

No, it is not a replacement for conventional cancer treatment; it should be used as a complementary therapy under the guidance of a healthcare professional.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/31333449/ – This meta-analysis of 4,246 cancer patients found that Coriolus versicolor and Ganoderma lucidum related products were associated with a lower mortality risk and higher total efficacy in cancer treatment. The study suggests potential benefits in cancer treatment outcomes, but notes heterogeneity among studies and the need for more research for specific cancer types.
https://libguides.usc.edu/healthsciences/systematicreviews/databases – This resource provides guidance on conducting systematic reviews and meta-analyses in health sciences. It offers information on various databases and tools that can be used to identify relevant studies for systematic reviews, aiding in the synthesis of evidence-based information.
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/coriolus-versicolor – Memorial Sloan Kettering Cancer Center provides an overview of Coriolus versicolor, highlighting its use in traditional medicine and potential benefits for immune support and cancer treatment. The resource discusses the active compounds and potential side effects, emphasizing the need for more rigorous research to confirm its efficacy.
https://jmla.pitt.edu/ojs/jmla/article/download/1223/1368 – This resource discusses the importance of evidence-based information in healthcare. It emphasizes the need for rigorous research and systematic reviews to inform clinical practice and decision-making, ensuring that healthcare interventions are effective and safe.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00703/full – This study explores the pharmacological properties of Coriolus versicolor, focusing on its immunomodulatory effects and potential applications in cancer treatment. The research highlights the role of polysaccharides in stimulating immune responses and suggests potential benefits in improving survival and quality of life for cancer patients.