Coriolus Versicolor Fruiting Body Extract
Also known as: Turkey Tail, Yunzhi, *Trametes versicolor*, *Coriolus versicolor*
Overview
*Coriolus versicolor*, commonly known as Turkey Tail, is an edible mushroom from the Polyporaceae family, recognized for its vibrant color and distinctive shape. Traditionally, it has been used in folk and traditional Chinese medicine for its energizing and healing properties. This medicinal mushroom is particularly noted for its role as an adjunctive therapy in cancer treatment, aimed at enhancing immune responses and alleviating the adverse effects of chemotherapy and radiation. Key active ingredients include polysaccharide peptide (PSP) and polysaccharide krestin (PSK), which are credited with immune-boosting and potential anti-cancer effects. The body of evidence on the efficacy of *Coriolus versicolor* is substantial, supported by numerous clinical trials and systematic reviews, solidifying its relevance in integrative oncology.
Benefits
Evidence suggests that *Coriolus versicolor* offers several health benefits, particularly in oncology settings. A meta-analysis found it associated with a reduced mortality risk (HR: 0.82) and improved efficacy outcomes (RR: 1.30) among cancer patients. Additionally, it provides a notable 9% absolute reduction in 5-year mortality rates in specific cancers like breast and colorectal cancer. Its immune-boosting impact is evidenced by increased levels of CD3 and CD4 T cells, enhancing overall immune function. Patients with colorectal cancer also report improved disease-free survival when combined with conventional treatments. The evidence is of high quality, derived from systematic reviews and RCTs, affirming its clinical significance.
How it works
The immunological effects of *Coriolus versicolor* are primarily attributed to its bioactive polysaccharides, PSP and PSK, which stimulate T cells and natural killer cells while modulating cytokine production. These polysaccharides exert anti-inflammatory effects by inhibiting key pro-inflammatory cytokines such as IL-6 and IL-8. The extract demonstrates beneficial interactions with the immune system, enhancing its functionality and mitigating side effects of cancer therapies. Enhanced bioavailability is achieved through hot water extraction, breaking down chitinous structures to release active components effectively.
Side effects
*Coriolus versicolor* is generally regarded as safe when complemented with conventional cancer treatments. While studies report limited data on its side effects, no significant adverse events or common side effects exceeding 5% have been documented. Rare side effects are also not conclusively evidenced. Potential drug interactions, particularly with anticancer agents like tamoxifen, require caution, though significant interactions have not been consistently observed. It is advised for individuals with severe immune deficiencies or those receiving immunosuppressive therapies to exercise caution. Pregnant or breastfeeding women should consult healthcare professionals due to insufficient data on safety in these populations.
Dosage
Recommended dosages for *Coriolus versicolor* typically range from 1 to 3 grams daily for the polysaccharide extract (either PSP or PSK). Studies highlight a 3-gram daily dose for colorectal cancer patients as being particularly effective in boosting survival rates. There is no established upper limit for safety, though doses above 3 grams are less frequently studied. The extract is best taken in conjunction with conventional treatments to maximize immune benefits, and hot water extraction is recommended to ensure bioavailability of active polysaccharides.
FAQs
Is *Coriolus versicolor* safe?
*Coriolus versicolor* is generally considered safe when used as directed. However, potential interactions with medications should be observed.
Can I take it while undergoing cancer treatment?
Yes, *Coriolus versicolor* can be taken alongside conventional cancer therapies, but consultation with a healthcare provider is recommended.
What outcomes can I expect?
Users may experience improved immune function, fewer side effects from chemotherapy, and potentially enhanced survival rates.
Is it a substitute for cancer treatment?
No, *Coriolus versicolor* is an adjunct therapy and should not replace conventional cancer treatments.
Research Sources
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.857864/full – This systematic review and meta-analysis evaluated the effects of *Coriolus versicolor* and related fungi on mortality and treatment efficacy in cancer patients, finding significant benefits in survival outcomes.
- https://pubmed.ncbi.nlm.nih.gov/31333449/ – A Cochrane review analyzed the role of *Coriolus versicolor* specifically in colorectal cancer, reporting low-certainty evidence of benefits while highlighting a need for further studies.
- https://www.cochrane.org/CD012053/COLOCA_coriolus-versicolor-mushroom-colorectal-cancer – This review assessed various studies on *Coriolus versicolor* in colorectal cancer treatments, noting potential survival benefits but uncertain outcomes on adverse effects.
- https://pubmed.ncbi.nlm.nih.gov/33260615/ – Research from 2020 investigated the anti-inflammatory and anti-cancer effects of *Coriolus versicolor*, demonstrating cytotoxic effects on cancer cells and inhibition of inflammatory factors in vitro.
- https://www.va.gov/WHOLEHEALTHLIBRARY/tools/mycomedicinals-mushrooms-for-cancer.asp – *Coriolus versicolor* is highlighted as a therapeutic mushroom for cancer, with insights into its historical use and modern research findings on its adjunctive role in cancer therapy.