Cornus Officinalis Extract
Also known as: Cornelian Cherry, Shan Zhu Yu, Cornus officinalis
Overview
Cornus officinalis is a deciduous shrub or small tree native to Asia, recognized for its medicinal uses, particularly the fruit. Traditionally employed in Traditional Chinese Medicine (TCM) for its tonifying properties on the kidney and liver, it is now being researched for its anti-inflammatory, antioxidant, antidiabetic, and neuroprotective effects. Rich in bioactive compounds like iridoids (such as loganin and morroniside), flavonoids, and organic acids, this herbal supplement has shown potential in animal studies. However, the maturity level of research is moderate, largely composed of in vitro and animal studies; robust human clinical trials are still needed to support its efficacy and safety conclusively.
Benefits
Cornus officinalis exhibits several evidence-based benefits, including potential anti-osteoporotic and anti-obesity effects noted in animal models. There are indications of neuroprotective and cardiovascular benefits, attributed to its antioxidant and anti-inflammatory properties which may enhance overall health. The extract may be particularly beneficial for women experiencing menopausal symptoms and for improving bone health in postmenopausal women. Existing animal studies showcase positive effects, yet specific human effect sizes remain poorly documented. Overall, while the benefits are promising, comprehensive clinical data on time course and efficacy in humans are lacking.
How it works
The mechanisms of action for Cornus officinalis involve the modulation of estrogen receptors, which play a key role in influencing bone and fat metabolism. Additionally, its antioxidant and anti-inflammatory properties collectively impact the skeletal, endocrine, and cardiovascular systems. The extract targets specific molecular pathways, showing interaction with genes such as PPARG, PRKACA, and NR3C1. However, further studies are needed to better understand its bioavailability and absorption characteristics.
Side effects
Cornus officinalis is generally considered safe based on its traditional usage, with limited adverse effects documented. Some individuals may experience gastrointestinal upset, although this is uncommon. There is currently no data on rare side effects. Caution is advised for those on medications affecting blood sugar or blood pressure due to potential interactions. Its use during pregnancy and breastfeeding is also discouraged due to insufficient safety data. Special considerations should be made for individuals managing diabetes, as its antidiabetic properties may alter blood sugar levels.
Dosage
Recommended dosage of Cornus officinalis is not well-established, and it is typically used in traditional formulations without standard dosing guidelines. Optimal dosage ranges and timing specific to conditions remain undefined. The extract is commonly employed in its dried fruit or extract forms in TCM, yet the maximum safe dose has not been clearly defined. Individuals intending to use this supplement should consult healthcare providers for tailored advice on dosage, considering that absorption factors have not been sufficiently studied.
FAQs
Is Cornus officinalis safe to use?
While generally safe in traditional use, modern safety data in humans are limited; consult a healthcare provider before use.
How should I take Cornus officinalis?
Follow traditional guidelines or consult a healthcare provider for tailored usage directions.
What benefits can I expect?
Potential benefits may include improved bone health and alleviation of menopausal symptoms, though more research is necessary.
Can it replace my regular medications?
No, it should not be considered a substitute for established medical treatments without evidence.
Research Sources
- https://www.mdpi.com/2072-6643/12/2/369 – This study highlights the anti-menopausal effects of *Cornus officinalis* in ovariectomized mice, demonstrating improvements in bone density and fat metabolism, indicating potential applications for menopausal health.
- https://pubmed.ncbi.nlm.nih.gov/38274211/ – A pharmacological review of *Cornus officinalis* indicates its potential role in managing osteoporosis through bioactive compounds, emphasizing the need for clinical trials to validate these findings.
- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1289144/full – An analysis of the active ingredients in *Cornus officinalis* revealed key molecular targets and pathways for its therapeutic effects, presenting a groundwork for future empirical studies.
- https://francis-press.com/papers/16922 – This paper discusses the pharmacological properties of *Cornus officinalis*, supporting its traditional use with theoretical insights into its potential health benefits.
- https://www.mdpi.com/2223-7747/10/11/2347 – This research reviews the composition and pharmacological activities of *Cornus officinalis*, advocating for more rigorous clinical studies to substantiate its efficacy and safety.