Cornus Officinalis Fruit Extract
Also known as: Asiatic Dogwood, Shan Zhu Yu, Cornus officinalis
Overview
Cornus officinalis, commonly known as Asiatic Dogwood or Shan Zhu Yu, is a deciduous shrub or small tree native to East Asia. This plant is particularly valued in traditional Chinese medicine for its bright red edible fruit, which is rich in bioactive compounds including flavonoids, iridoids, and phenolic acids. These compounds contribute to its noted medicinal properties, which include anti-inflammatory, antioxidant, antidiabetic, and neuroprotective effects. Despite a moderate level of research maturity, the existing data highlights its significance in treating various health conditions, though further clinical trials are essential to better establish its efficacy and safety in human populations.
Benefits
The primary documented benefits of Cornus officinalis include potent antioxidant activity, which is crucial in protecting against oxidative stress-related diseases. Additionally, studies have suggested antidiabetic effects, evidenced by the potential to lower blood glucose levels and enhance insulin sensitivity. Neuroprotective effects have also been identified, showing its ability to mitigate oxidative stress and improve cognitive function. Furthermore, it may provide cardiovascular advantages by optimizing lipid profiles. These benefits appear most notable in populations with diabetes or cardiovascular risk factors. However, while promising, the current data quality is variable, and more robust clinical evidence is required to confirm these benefits and their effect sizes.
How it works
Cornus officinalis primarily exerts its effects through its antioxidant properties, which help neutralize free radicals and reduce oxidative stress. It may also enhance insulin signaling pathways, potentially improving glucose metabolism and lipid profiles. The bioactive compounds interact with various biological systems, influencing genes involved in metabolism and inflammation. Although the exact absorption mechanism is not well-studied, it is believed that the efficacy of its active compounds can be influenced by the method of extraction and the formulation used.
Side effects
Cornus officinalis is generally considered to have a good safety profile when used appropriately, yet comprehensive safety assessments are still limited. The most common side effects, occurring in over 5% of users, are not well documented, but gastrointestinal discomfort has been mentioned. Less frequent adverse effects, such as allergic reactions, may occur in about 1-5% of users. There are no well-documented rare side effects, occurring in less than 1%. Caution is advised regarding potential drug interactions, especially with diabetes medications and blood-thinning agents. Pregnant and breastfeeding women should avoid this supplement due to inadequate safety data. Special caution should also be exercised in populations with pre-existing chronic conditions or those on multiple medications.
Dosage
Currently, there is no established minimum effective dose for Cornus officinalis, as optimal dosages can vary depending on specific formulations and health conditions. Traditionally, it is consumed in dried fruit form or as an extract, but the lack of standardized dosing recommends caution. The maximum safe dosage is also not well-defined; therefore, users are advised to avoid excessive consumption. Timing for administration has not been standardized and may be contingent upon individual conditions. It is suggested that taking it with meals may enhance the absorption of its bioactive components.
FAQs
Is Cornus officinalis safe to use?
Generally considered safe, but it's essential to consult a healthcare provider, especially if you have health conditions or are on medications.
How should I take Cornus officinalis?
There is no standardized dose; follow traditional usage guidelines or consult a healthcare professional for personalized advice.
What results can I expect?
Results can vary; some users may notice benefits over time while others may not experience significant effects.
Does Cornus officinalis interact with medications?
It may interact with diabetes medications and blood thinners, so consult a healthcare provider before use.
Can pregnant women use this supplement?
It is not recommended for pregnant or breastfeeding women due to the lack of safety data.
Research Sources
- https://www.mdpi.com/2304-8158/11/9/1240 – This review investigates the diverse pharmacological effects of Cornus officinalis, highlighting its antioxidant, antidiabetic, and neuroprotective properties while emphasizing the necessity for more clinical trials to substantiate these findings.
- https://pubmed.ncbi.nlm.nih.gov/38274211/ – This study discusses various in vitro and animal studies demonstrating the potential health benefits of Cornus officinalis, particularly its antioxidant and antidiabetic effects, but acknowledges the limitation of human clinical data.
- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1289144/full – A network pharmacology analysis providing insights into key genes and pathways influenced by Cornus officinalis. While revealing potential therapeutic mechanisms, it stresses the need for experimental validation.