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Cratevox

Also known as: Crataeva religiosa, Crataeva magna, Three-leaved Caper, Varuna, Crataeva nurvala

Overview

*Crataeva nurvala*, commonly known as Three-leaved Caper or Varuna, is a herbal supplement derived from a plant native to tropical Asia. Traditionally utilized to treat urinary disorders, it primarily addresses conditions such as overactive bladder (OAB), urinary frequency, and urgency. The stem bark is the main component used for medicinal purposes. Emerging research suggests potential efficacy, particularly in reducing symptoms of OAB, yet the quantitative and qualitative evidence remains inconclusive, predominantly relying on small-scale trials and preliminary animal studies. Further, extensive studies are required to bolster its therapeutic claims and elucidate its safety profile and exact mechanism of action.

Benefits

The primary benefit of *Crataeva nurvala* is its ability to alleviate symptoms of overactive bladder (OAB), including urinary frequency and urgency. In studies, formulations containing this extract, such as Urox, have demonstrated significant reductions in urinary frequency and occurrences of nocturia when compared to placebo. Secondary effects of the plant may include improved bladder muscle tone and reduced muscle spasms. Individuals suffering from OAB, particularly those seeking alternative treatments, may find the use of this herb beneficial. Clinical evidence reveals that positive effects can manifest as early as 8 weeks into treatment, yielding improvements in quality of life.

How it works

While the precise mechanism of action for *Crataeva nurvala* remains largely undetermined, it appears to enhance bladder muscle tone and alleviate spasms. This is crucial for stabilizing urinary function, particularly in individuals experiencing OAB. The lack of detailed molecular targets in current literature necessitates further investigation to fully elucidate how it interacts with urinary system pathways.

Side effects

Overall, *Crataeva nurvala* is generally regarded as safe, with minimal side effects reported in existing studies. No common, uncommon, or rare adverse effects have been documented in substantial numbers. Additionally, no significant drug interactions have been noted, including interactions with the P450 cytochrome system. Despite the absence of documented contraindications, it is advisable for individuals, particularly those on concurrent medications, to consult healthcare professionals prior to usage. This precaution is essential to mitigate potential risks, especially among vulnerable populations.

Dosage

The effective dosage of *Crataeva nurvala* as a standalone supplement has not been well defined, as it is frequently included in proprietary blends like Urox. Consequently, optimal dosages vary based on the specific product formulation. Users are encouraged to adhere to product instructions or seek advice from healthcare providers for appropriate dosing. Current literature does not establish any maximum safe dose, and factors influencing absorption and bioavailability require additional study for clarity.

FAQs

Is *Crataeva nurvala* safe to use?

Generally considered safe, but consult a healthcare professional before starting, especially if on other medications.

How should I take *Crataeva nurvala*?

Follow the product's instructions or seek guidance from a healthcare provider regarding timing and dosage.

What results can I expect from using *Crataeva nurvala*?

Users may experience a reduction in symptoms associated with overactive bladder (OAB).

Can *Crataeva nurvala* cure OAB?

*Crataeva nurvala* is not a cure but may effectively manage and alleviate symptoms of OAB.

Are there any misconceptions about *Crataeva nurvala*?

Some believe it provides immediate relief; however, benefits are typically noted after several weeks of consistent use.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/29385990/ – A randomized, double-blind, placebo-controlled trial with 150 OAB participants found that Urox, containing *Crataeva nurvala*, significantly reduced urinary frequency and nocturia over 8 weeks, indicating promise for OAB management.
https://www.medicalnewstoday.com/articles/crataeva-nurvala-for-overactive-bladder – Overview article discussing the potential applications of *Crataeva nurvala* for treating urinary disorders, emphasizing the need for further human studies to confirm benefits seen in animal research.
https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2022.896624/full – This systematic review discusses various treatments for OAB, pointing out gaps in research on herbal treatments, including *Crataeva nurvala*, highlighting their potential but indicating a need for robust clinical studies.
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1014291/full – Another systemic review focusing on the need for more comprehensive human trials for herbal supplements, noting the unclear efficacy of *Crataeva nurvala* based on existing literature.
https://seipelgroup.com/urox/ – The official website providing information about Urox, which includes *Crataeva nurvala*, outlining its formulation, efficacy, and available clinical evidence supporting its use for OAB.