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Cyathula

Also known as: Cyathula prostrata, Cyathula officinalis, Chuaniuxi

Overview

Cyathula encompasses several plant species within the Amaranthaceae family, with *Cyathula prostrata* and *Cyathula officinalis* being the most researched. *Cyathula prostrata* is traditionally used to enhance male fertility, while *Cyathula officinalis*, also known as Chuaniuxi, is used for treating osteoarthritis. These plants contain bioactive compounds that exhibit anti-inflammatory and immunomodulatory effects. Research on Cyathula is still emerging, with most studies focusing on specific applications rather than comprehensive evaluations. The available evidence is primarily based on animal studies and small-scale human trials, highlighting the need for more robust systematic reviews and meta-analyses to validate its efficacy and safety. Cyathula extracts are typically prepared from the plant's leaves and roots, often using ethanol extraction methods to isolate the active compounds.

Benefits

*Cyathula prostrata* has demonstrated potential in enhancing sperm count, motility, and morphology in animal studies, suggesting a possible benefit for male fertility. However, human studies are needed to confirm these effects. *Cyathula officinalis* may offer anti-inflammatory benefits for individuals with osteoarthritis, supported by research indicating its involvement in anti-inflammatory pathways. The strength of evidence for these benefits is currently limited, as most studies are preclinical or small-scale. Further research is necessary to determine the clinical significance and specific effect sizes in human populations. The potential immunomodulatory effects of Cyathula could also contribute to broader health benefits, but this remains largely unexplored.

How it works

*Cyathula officinalis* exerts its anti-inflammatory effects through the modulation of the MAPK and NF-κB pathways, which are key regulators of inflammation. These pathways are involved in the production of inflammatory cytokines and other mediators. By interfering with these pathways, *Cyathula officinalis* can potentially reduce inflammation and alleviate symptoms of conditions like osteoarthritis. The exact molecular targets and mechanisms of action are still under investigation. Further research is needed to fully elucidate how Cyathula interacts with various body systems and the specific molecular targets involved.

Side effects

The safety profile of Cyathula in humans is not well-established due to limited data. Animal studies have indicated the potential for adverse effects at high doses, but specific side effects and their frequency are not well-documented. Common, uncommon, and rare side effects in humans have not been identified. Drug interactions with Cyathula are also not well-studied, and contraindications have not been established. Special caution is advised for pregnant and lactating women, as the effects of Cyathula on these populations are unknown. Given the limited safety data, it is crucial to exercise caution and consult with a healthcare professional before using Cyathula supplements.

Dosage

Due to the limited human studies, a minimum effective dose, optimal dosage ranges, and maximum safe dose for Cyathula have not been established. Animal studies involving *Cyathula prostrata* have used doses ranging from 50-300 mg/kg body weight. However, these dosages cannot be directly translated to human use. Timing considerations and form-specific recommendations are also not well-defined. Ethanol leaf extracts have been used in research, but the absorption factors and required cofactors are not established. Until more research is available, it is not possible to provide specific dosing guidelines for Cyathula.

FAQs

Is Cyathula safe for human consumption?

The safety of Cyathula for human consumption is not well-established. Limited data from animal studies suggest potential adverse effects at high doses. Consult with a healthcare professional before use.

What are the potential benefits of Cyathula?

Animal studies suggest potential benefits in male fertility and osteoarthritis. However, human evidence is limited, and more research is needed to confirm these effects.

How should Cyathula be taken?

There are no established dosing guidelines for Cyathula in humans. Timing and administration methods are not well-studied. Consult with a healthcare professional for personalized advice.

Are there any known drug interactions with Cyathula?

Drug interactions with Cyathula are not well-studied. Exercise caution and consult with a healthcare professional if you are taking other medications.

Can Cyathula be used during pregnancy or lactation?

The effects of Cyathula during pregnancy and lactation are unknown. It is advisable to avoid use during these periods due to the lack of safety data.

Research Sources

https://tjnpr.org/index.php/home/article/view/542 – This study investigated the effects of *Cyathula prostrata* ethanol leaf extract on sperm parameters in rats. The extract enhanced sperm count, motility, and morphology, suggesting potential benefits for male fertility. However, high doses caused adverse effects, highlighting the need for caution.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1397359/full – This research explores the potential of *Cyathula officinalis* in treating osteoarthritis. The study indicates that *Cyathula officinalis* exerts anti-inflammatory effects through the modulation of the MAPK and NF-κB pathways. These findings suggest a possible mechanism for alleviating osteoarthritis symptoms.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10958415/ – This article discusses the traditional uses and pharmacological potential of various Cyathula species. It highlights the need for more comprehensive human studies to validate the efficacy and safety of Cyathula in treating various conditions. The review emphasizes the importance of rigorous scientific investigation to support traditional claims.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9117623/ – This study investigates the anti-inflammatory and analgesic effects of Cyathula extracts. The results suggest that Cyathula possesses significant anti-inflammatory properties, which could be beneficial in managing pain and inflammation-related conditions. Further research is needed to identify the specific active compounds responsible for these effects.
https://academic.oup.com/rpsppr/article/2/4/rqad041/7453514 – This article reviews the phytochemistry and pharmacological activities of Cyathula species. It provides an overview of the various bioactive compounds found in Cyathula and their potential therapeutic applications. The review underscores the need for more in-depth studies to fully understand the pharmacological potential of Cyathula.