Cynanchum Wilfordi Root Extract
Also known as: Cynanchum wilfordi, Cynanchum, Cynanchum root extract, Chinese Asparagus, Cynanchum wilfordii
Overview
Cynanchum wilfordii, commonly known as Chinese Asparagus, is an herbal plant native to East Asia, particularly prevalent in Korea and China. Traditionally used in folk medicine, the root extract has gained popularity for its efficacy in managing blood cholesterol levels and treating dyslipidemia. Its health benefits are attributed to bioactive compounds, notably alkaloids and glycosides, which exhibit properties such as anti-inflammatory, anti-cancer, and immunosuppressive effects. Despite the accumulation of moderate evidence from clinical trials and in vitro studies, further comprehensive research is warranted to fully understand its health benefits and mechanisms of action. Available in capsule or tablet forms, Cynanchum wilfordii shows potential as a natural supplement for improving lipid profiles.
Benefits
Cynanchum wilfordii has demonstrated significant benefits for lipid profile management, particularly in reducing total cholesterol and LDL-cholesterol levels. In a double-blind, placebo-controlled clinical trial, daily doses of 300 mg and 600 mg resulted in reductions of 4.0% and 3.8% in total cholesterol, and 6.4% and 5.8% in LDL-cholesterol respectively. Furthermore, declines in triglycerides and VLDL levels were also observed. The extract provides anti-inflammatory and immunosuppressive effects due to its bioactive compounds, which inhibit immune cell proliferation and reduce inflammatory markers. Individuals with elevated LDL-cholesterol may benefit the most, with improvements typically visible within 8 weeks of consistent supplementation. The evidence supporting its lipid management properties is of moderate quality, emphasizing the need for additional studies.
How it works
Cynanchum wilfordii root extract’s mechanisms of action are not completely detailed, but it is postulated that its bioactive compounds modulate lipid metabolism by potentially inhibiting cholesterol synthesis or enhancing cholesterol excretion. The extract interacts with the cardiovascular system to improve lipid profiles while also exerting anti-inflammatory effects on immune cell activity. Key molecular targets involve enzymes that are crucial in cholesterol synthesis and the proliferation of immune cells, indicating a multifaceted role in lipid management and immune response modulation.
Side effects
Cynanchum wilfordii root extract is typically recognized as safe when consumed at recommended dosages. The most commonly reported side effects are mild gastrointestinal discomfort; however, such occurrences are rare. The literature does not indicate any significant adverse effects, including serious adverse events. Despite its apparent safety, individuals should exercise caution when using this supplement alongside other medications affecting lipid metabolism or immune function. Pregnant or breastfeeding women are advised to seek counsel from healthcare providers prior to use. Individuals with pre-existing health conditions, especially connected to cardiovascular health, should consult a healthcare professional to assess any potential impact the extract may have on their lipid profiles.
Dosage
The clinically established effective daily dose of Cynanchum wilfordii root extract ranges from 300 mg to 600 mg, with 300 mg being the minimum effective amount. Clinical trials have confirmed efficacy at both dosage levels without significant adverse events reported. Consistent use of the supplement is encouraged, and while specific timing is not critical, there is evidence suggesting enhanced absorption of bioactive compounds when taken with food. There is no defined maximum safe dose, but up to 600 mg per day has been well tolerated. Further investigation is necessary to clarify absorption dynamics and timing recommendations.
FAQs
Is Cynanchum wilfordii safe?
Yes, it is generally considered safe but may cause gastrointestinal discomfort in some individuals.
When should I take Cynanchum wilfordii?
It can be taken at any time, but consistency in taking the supplement is essential for the best results.
What benefits can I expect?
Users may see improvements in lipid profiles, especially reductions in total cholesterol and LDL-cholesterol, within about 8 weeks.
Can it replace my medication?
No, it should not replace medical treatments but may complement them under healthcare provider guidance.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/24024166/ – This study assesses the efficacy of Cynanchum wilfordii root extract on lipid levels in subjects with dyslipidemia. It demonstrates that daily dosages of 300 mg and 600 mg result in significant reductions in total cholesterol and LDL-cholesterol over a sustained period, highlighting the potential of the extract as a natural remedy.
- https://pubmed.ncbi.nlm.nih.gov/29797764/ – This research article evaluates the chemical constituents of Cynanchum wilfordii, including its alkaloids and glycosides, and discusses their pharmacological properties. The findings support its traditional uses and underscore the need for further research to fully characterize its health benefits.
- https://www.sciencedirect.com/science/article/abs/pii/S0378874117301605 – A systematic review that discusses the role of Cynanchum wilfordii in cardiovascular health. It reviews various clinical trials and provides insight into the mechanisms of action by which the extract aids in lipid management, supporting its traditional applications in medicine.