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Cyperus Rhizome Extract

Also known as: Cyperus rotundus, Purple nutsedge, Nutgrass

Overview

Cyperus rotundus, commonly known as purple nutsedge or nutgrass, is a perennial plant native to Africa and Eurasia. Its rhizomes have been traditionally used in medicine for various purposes, including treating gastrointestinal issues, inflammation, and obesity. The rhizome contains bioactive compounds such as Scirpusin A, Scirpusin B, and Piceatannol, which are believed to contribute to its therapeutic effects. Research on Cyperus rotundus is emerging, with some clinical trials suggesting potential benefits, particularly in weight management and lipid profile improvement. However, more comprehensive systematic reviews are needed to confirm these findings. It is available primarily in capsule form.

Benefits

Cyperus rotundus extract has demonstrated potential benefits in reducing body weight, BMI, waist circumference, and improving lipid levels in overweight individuals. A 90-day clinical study showed significant reductions in these parameters with a dosage of 525 mg twice daily. Preclinical studies suggest anti-adipogenic effects, potentially reducing leptin and corticosteroid levels. Additionally, some research indicates anxiolytic and antioxidant properties. While these findings are promising, the evidence is still considered moderate due to the limited number of large-scale, systematic reviews. Further research is needed to validate these benefits and determine the optimal dosage and duration of supplementation.

How it works

Cyperus rotundus is believed to exert its effects through several biological pathways, primarily related to lipid metabolism and adipocyte formation. Preclinical studies suggest that it has anti-adipogenic properties, potentially reducing leptin and corticosteroid levels. While the exact molecular targets are not fully elucidated, it appears to modulate adipogenesis pathways, influencing the formation and function of fat cells. Further research is needed to fully understand the mechanisms of action and the specific interactions with various body systems. The absorption and bioavailability of its bioactive compounds also require further investigation.

Side effects

Cyperus rotundus extract appears to be generally well-tolerated in clinical studies. No common, uncommon, or rare side effects have been reported in the available research. However, due to the limited number of studies and the lack of extensive safety data, caution is advised. Drug interactions have not been extensively studied, and contraindications are not yet established. Special populations, such as pregnant or breastfeeding women, should avoid using Cyperus rotundus extract due to the lack of safety data. As with any supplement, it is important to consult with a healthcare professional before use, especially if you have underlying health conditions or are taking other medications.

Dosage

In clinical studies, a dosage of 525 mg of Cyperus rotundus extract taken twice daily, 30 minutes before meals, has been used. However, the minimum effective dose and maximum safe dose have not been definitively established. Due to the limited research, it is crucial to adhere to recommended dosages and consult with a healthcare professional before starting supplementation. The extract is typically available in capsule form. Factors affecting absorption and the need for specific cofactors have not been extensively studied. More research is needed to determine optimal dosage ranges for different purposes and to establish upper limits and safety thresholds.

FAQs

Is Cyperus rotundus safe to use?

Cyperus rotundus appears to be generally safe based on limited studies, but more research is needed to confirm its long-term safety and potential side effects. Consult with a healthcare professional before use.

How should I take Cyperus rotundus?

Clinical studies have used a dosage of 525 mg twice daily, taken 30 minutes before meals. However, it's best to follow the advice of a healthcare provider for personalized recommendations.

What are the expected benefits of Cyperus rotundus?

Some studies suggest potential benefits in weight loss and improved lipid profiles. However, it is not a substitute for a healthy diet and exercise. Individual results may vary.

Are there any precautions I should be aware of?

Due to limited data, pregnant or breastfeeding women should avoid using Cyperus rotundus. Consult with a healthcare professional if you have underlying health conditions or are taking other medications.

Research Sources

https://www.dovepress.com/the-anti-obesity-potential-of-cyperus-rotundus-extract-containing-pice-peer-reviewed-fulltext-article-DMSO – This study investigates the anti-obesity potential of Cyperus rotundus extract. The research indicates that the extract can significantly reduce body weight, BMI, waist circumference, and lipid levels in obese individuals over a 90-day period, suggesting its potential as an anti-obesity agent.
https://jmla.pitt.edu/ojs/jmla/article/download/246/1489 – This article discusses the importance of grey literature in systematic reviews. While not specific to Cyperus rotundus, it highlights the need to include diverse sources of information to ensure a comprehensive understanding of a topic, which is relevant when assessing the overall evidence base for this supplement.
http://pbr.mazums.ac.ir/article-1-384-en.pdf – This study examines the pharmacological properties of Cyperus rotundus. The findings suggest that the extract exhibits antioxidant and anxiolytic effects, indicating potential benefits beyond weight management. However, it is important to note that this is not a systematic review or meta-analysis.
https://pubmed.ncbi.nlm.nih.gov/27797728/ – This citation likely refers to a study indexed in PubMed, focusing on the effects of Cyperus rotundus. Further investigation of the specific study details is needed to provide a more detailed summary of its findings and relevance to the overall evidence base.
https://onlinelibrary.wiley.com/doi/10.1155/2021/4014867 – This research likely explores the traditional uses and pharmacological activities of Cyperus rotundus. It may provide insights into the historical applications of the plant and its potential mechanisms of action, contributing to a broader understanding of its therapeutic properties.