Cyperus Rotundus Rhizome Extract
Also known as: Purple nutsedge, Nutgrass, Cyperus, Nut grass, Cyperus rotundus
Overview
*Cyperus rotundus* is a perennial herbaceous plant native to tropical and subtropical regions, renowned for its traditional medicinal applications. Used for centuries in various cultures to treat ailments like diarrhea, diabetes, and inflammation, the rhizome extract comprises bioactive compounds such as Piceatannol, Scirpusin A, and Scirpusin B, which are thought to contribute to its therapeutic efficacy. The extract is primarily examined for its potential anti-obesity, anti-inflammatory, and antioxidant properties. Despite its promising phytochemical composition and biological activities, the number of high-quality, randomized clinical trials remains limited, indicating a need for further research to validate these findings.
Benefits
Research indicates several benefits associated with *Cyperus rotundus* rhizome extract (CRE). A pilot clinical study by Majeed et al. reported significant reductions in body weight, BMI, waist circumference, and lipid levels among obese individuals following a 90-day supplementation period. Additionally, CRE exhibits anti-adipogenic properties that might further aid weight management. Secondary benefits include anti-inflammatory and antioxidant effects, supported by ethnopharmacological studies. Given these findings, overweight individuals may experience notable improvements in body composition and metabolic health when using CRE.
How it works
The mechanism of action of *Cyperus rotundus* rhizome extract involves the inhibition of adipogenesis, thereby reducing the formation of fat cells, and modulating levels of hormones such as leptin and corticosteroids. The bioactive compounds within the extract interact with metabolic and lipid metabolism pathways, promoting weight loss successes seen in clinical trials. However, specific molecular mechanisms and the bioavailability of these compounds are yet to be fully elucidated.
Side effects
*Cyperus rotundus* rhizome extract is generally considered well-tolerated with no significant adverse effects reported in available clinical studies. There have been no common, uncommon, or rare side effects documented. Drug interaction data does not suggest significant concerns; however, caution is warranted for pregnant or breastfeeding women, as the safety profile in these populations is not well-established. Consultation with healthcare providers is recommended for individuals with chronic conditions prior to use.
Dosage
The minimum effective dose for *Cyperus rotundus* rhizome extract as reported in clinical studies is 525 mg, administered twice daily. While this dosage was effective, an optimal dosage range and maximum safe dose have not been firmly established beyond this studied amount. Administration is recommended to occur 30 minutes before meals for best effects. Form-specific recommendations indicate that the capsule form was utilized in clinical trials, but additional absorption factors remain undocumented.
FAQs
Is there a recommended way to take *Cyperus rotundus*?
Take *Cyperus rotundus* rhizome extract 30 minutes before meals for optimal results.
Is *Cyperus rotundus* safe for everyone?
While generally safe, pregnant or breastfeeding women should consult a healthcare provider before use due to insufficient safety data.
What results can I expect from taking this supplement?
Weight loss and improved lipid profiles may be expected, particularly in overweight individuals when taken as recommended.
Can I use this supplement instead of a healthy diet and exercise?
No, *Cyperus rotundus* is not a substitute for maintaining a healthy diet and exercise regimen.
Are there any known side effects?
No side effects have been reported in studies; however, individual experiences may vary.
Research Sources
- https://www.dovepress.com/the-anti-obesity-potential-of-cyperus-rotundus-extract-containing-pice-peer-reviewed-fulltext-article-DMSO – This pilot clinical study explored *Cyperus rotundus* rhizome extract's effects on overweight individuals, concluding significant reductions in weight, BMI, and lipid levels over a 90-day duration. The study's double-blinded design strengthens the validity of findings despite a small sample size.
- https://pubmed.ncbi.nlm.nih.gov/26297840/ – This ethnopharmacological review compiled the traditional uses and phytochemical profiles of *Cyperus rotundus*, emphasizing its potential as an anti-obesity, anti-inflammatory, and antioxidant agent. It highlights the wealth of empirical support while pointing out the lack of clinical trial focus.
- https://onlinelibrary.wiley.com/doi/10.1155/2021/4014867 – Investigating the antimicrobial properties of *Cyperus rotundus* rhizome, this study affirms its bioactive potential, indirectly supporting its health benefits related to supplementation, although it concentrates on food preservation rather than human health.
- https://pubmed.ncbi.nlm.nih.gov/27777450/ – Highlighting the diverse phytochemistry and ethnobotanical significance of *Cyperus rotundus*, this study underlines its historical applications and invites further investigation into its health-promoting activities.
- https://www.researchgate.net/publication/355127455_Traditional_uses_phytochemistry_and_anticancer_potential_of_Cyperus_rotundus_L_Cyperaceae_A_systematic_review – This systematic review covers the traditional applications and phytochemical composition of *Cyperus rotundus*, examining its anticancer potential while summarizing its previously recognized benefits and calling for more clinical innovation.