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Dandelion Glycerite Liquid Extract

Also known as: Dandelion, common dandelion, Dandelion glycerite liquid extract, Taraxacum officinale

Overview

Dandelion glycerite liquid extract is derived from *Taraxacum officinale*, commonly known as common dandelion, a widely distributed plant with a long history of traditional use. This specific form utilizes glycerin as a solvent to extract water-soluble compounds, including beneficial polysaccharides, flavonoids, and phenolic compounds. While traditionally valued for its diuretic, digestive, and anti-inflammatory properties, current interest focuses on its potential to support metabolic health, liver function, and blood sugar regulation. Research on dandelion extracts is moderately developed, with a significant body of in vitro and animal studies. However, high-quality human clinical trials, particularly those specifically investigating glycerite extracts, are limited. Most available evidence stems from preclinical studies or those using aqueous or methanolic extracts, though the bioactive profile of glycerite is expected to be similar due to the water solubility of its key components.

Benefits

Preclinical evidence suggests several potential benefits for dandelion extracts, though robust human clinical data, especially for glycerite forms, are limited. Aqueous extracts of dandelion root have shown promise in **blood glucose regulation**, with animal studies demonstrating a significant reduction in blood glucose levels (e.g., 400 mg/kg in rats). This effect is likely mediated by the inhibition of carbohydrate-digesting enzymes like α-glucosidase and α-amylase, which reduces postprandial glucose absorption. Dandelion extracts also exhibit potential in alleviating **insulin resistance**, particularly when combined with other botanicals like *Astragalus* in in vitro models. Furthermore, the presence of flavonoids and phenolic compounds contributes to significant **anti-inflammatory and antioxidant effects**, which may indirectly support metabolic and liver health by reducing oxidative stress. While these findings are promising, most evidence is preclinical or from small-scale studies, and quantitative human data with established effect sizes and clinical significance are largely lacking. The potential benefits are most relevant for individuals with metabolic syndrome, prediabetes, or mild hyperglycemia, but further human trials are needed to confirm efficacy and optimal dosing.

How it works

Dandelion extracts exert their effects primarily through enzyme inhibition and antioxidant activity. They are known to inhibit α-glucosidase and α-amylase, enzymes crucial for breaking down carbohydrates in the digestive tract. By inhibiting these enzymes, dandelion can reduce the absorption of glucose, thereby mitigating postprandial blood sugar spikes. Additionally, the rich content of polysaccharides and flavonoids in dandelion contributes to its antioxidant and anti-inflammatory properties. These compounds help to combat oxidative stress and inflammation, which are implicated in the development of insulin resistance and metabolic dysfunction. While specific pharmacokinetic data for glycerite extracts are not available, the water-soluble nature of these key bioactive compounds suggests they are likely well-extracted and bioavailable, supporting systemic absorption and interaction with relevant biological pathways.

Side effects

Dandelion glycerite liquid extract is generally considered safe, reflecting its long history of traditional dietary and medicinal use. Adverse effects are rare but may include mild gastrointestinal discomfort, such as stomach upset or diarrhea, or allergic reactions in individuals sensitive to plants in the Asteraceae family (e.g., ragweed, chrysanthemums, marigolds). While no significant drug interactions or contraindications have been extensively documented in clinical trials, caution is advised when using dandelion with certain medications. Due to its traditional diuretic properties, it may have additive effects with prescription diuretics, potentially leading to electrolyte imbalances. Similarly, given its preclinical evidence for blood glucose regulation, it could theoretically enhance the effects of antidiabetic medications, necessitating careful monitoring of blood sugar levels to avoid hypoglycemia. There are no reports of serious adverse events from high-quality randomized controlled trials. Individuals with gallstones or bile duct obstruction should consult a healthcare professional before use, as dandelion can stimulate bile flow.

Dosage

There is currently no standardized or clinically validated dosing regimen for dandelion glycerite liquid extract based on robust human clinical trials. Preclinical studies, which often use aqueous extracts, have shown effective doses around 400 mg/kg in animal models. However, these animal doses do not directly translate to human recommendations without further specific research. Traditional herbal practices suggest empirical doses, often ranging from 1-2 mL of glycerite extract taken 2-3 times daily. It is important to note that these traditional recommendations are based on historical use rather than rigorous scientific evidence. The optimal dosage for specific health conditions, the best timing for administration, and any potential differences in dosing based on the extract's concentration or the individual's health status remain to be established through further clinical research. Users should follow product-specific instructions or consult with a healthcare professional for personalized guidance.

FAQs

Is dandelion glycerite effective for blood sugar control?

Preclinical evidence suggests dandelion extracts can inhibit enzymes that break down carbohydrates, potentially reducing postprandial glucose. However, robust human clinical trials specifically on glycerite extracts for blood sugar control are currently lacking.

Is dandelion glycerite safe for long-term use?

Dandelion is generally considered safe with a long history of use. While long-term safety data from randomized controlled trials are not available, adverse effects are rare and typically mild. Consult a healthcare professional for prolonged use.

Can dandelion glycerite be combined with other supplements?

In vitro studies suggest synergistic effects with other botanicals like *Astragalus* for insulin resistance. However, clinical confirmation is needed. Always consult a healthcare professional before combining supplements, especially with medications.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC9498421/ – This animal study investigated the effects of aqueous dandelion root extract, finding that a dose of 400 mg/kg significantly lowered blood glucose levels in rats. The research also demonstrated that dandelion inhibited α-glucosidase and α-amylase enzymes, suggesting a mechanism for its glucose-lowering effects. Additionally, in vitro experiments showed a synergistic effect when dandelion was combined with *Astragalus* extract on insulin resistance, highlighting its potential in metabolic health.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10343869/ – This literature review comprehensively identified and discussed the bioactive compounds present in dandelion, such as sesquiterpenes, polysaccharides, and flavonoids. It highlighted their significant antioxidant and metabolic effects, which contribute to dandelion's traditional medicinal uses. The review also described various extraction methods, including those relevant to obtaining water-soluble polysaccharides, which are pertinent to the composition and expected efficacy of glycerite extracts.